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Gene · 3691

ITGB4: integrin subunit beta 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ITGB4: integrin subunit beta 4. Genes, record 3691. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3691

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Gene

Symbol
ITGB4
HGNC
Name
integrin subunit beta 4
HGNC
NCBI Gene ID
3691
NCBI Gene
HGNC ID
HGNC:6158
HGNC
Ensembl
ENSG00000132470
NCBI Gene
Aliases
CD104, GP150, JEB5A, JEB5B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P16144Integrin beta-41,82213Ensembl, GeneID, HGNC

Source UniProt

Patents79

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449984P16144Espacenet
EP 4650780 A22025-11-19204P16144Espacenet
EP 4641201 A22025-10-29173P16144Espacenet
JP 2025529142 A2025-09-042151P16144Espacenet
US 12371689 B22025-07-292151P16144Espacenet
JP 2025517969 A2025-06-12173P16144Espacenet
JP 2025517970 A2025-06-12204P16144Espacenet
US 12291562 B22025-05-0611P16144Espacenet
JP 2025032204 A2025-03-1130095P16144Espacenet
EP 4461818 A22024-11-1330095P16144Espacenet

1 to 10 of 79

See all 79 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,117

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleITGB4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant222025
P30CA016672Cancer Center Support Grant152025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant82025
ZIAAI000416Recombinant Virus Vaccines82025
P30CA033572Cancer Center Support Grant72025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202872025
P30CA093373Cancer Center Support Grant P3072025
P30AI064518Center for AIDS Research62025
P30CA068485Cancer Center Support Grant62025
UM1AI068614HIV Vaccines Clinical Trials Network Leadership and Operations Center62025

1 to 10 of 2,117Source NIH's project files

See all 2,117 nih grants

Papers3,577

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated bioinformatics identification and independent validation of FLNA, CCL2, and VMO1 as candidate biomarkers for dexamethasone-induced glaucoma.Exp Eye Res202642810534PubTator, text miningPubMed
Zeb1 Is a Determinant of EMT in Human MDA-MB-231 Breast Cancer Cells and M13-MDA231 Tumor Hybrids.Int J Mol Sci202642794675PubTator, text miningPubMed
ST6GAL1 promotes cancer stem-like cell-associated paclitaxel resistance through the EGFR-mTOR-SOX2/BMI1 axis in non-small cell lung cancer.Cancer Drug Resist202642764906PubTator, text miningPubMed
Circulating Serum AGRN and ADAMTS8 With Related Candidates as Potential Biomarkers for Carotid Plaque Presence and Vulnerability.CNS Neurosci Ther202642747227PubTator, text miningPubMed
Loss of ST8SIA6 is associated with enhanced MUC16-Integrin β4 signaling and aggressive phenotypes in colorectal cancer.Biochem Biophys Rep202642698897PubTator, text miningPubMed
A Multi-Layered Proteogenomic Framework for the Prioritization of Cell Surface Therapeutic Targets: Proof-of-Concept for Metastatic Colorectal Cancer.Cancers (Basel)202642649884PubTator, text miningPubMed
The TCN1 Paradox: Unraveling the Dual Role of Transcobalamin I in Colorectal Cancer-From Metabolic Regulation to Oncogenic Signaling.Cancer Manag Res202642577958PubTator, text miningPubMed
Generation and characterization of an anti ITGB4 monoclonal antibody that blocks Zika virus entry.Front Immunol202642564182PubTator, text miningPubMed
RETRACTION: Shear-Induced ITGB4 Promotes Endothelial Cell Inflammation and Atherosclerosis.Oxid Med Cell Longev202642550461PubTator, text miningPubMed
Transcriptomic Profiling of the Effects of DDR1 in Breast and Ovarian Cancer to Understand the Association Between DDR1 Expression and Patient Survival.Genes (Basel)202642510800PubTator, text miningPubMed

1 to 10 of 3,577

See all 3,577 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3691

GET https://conductscience.org/api/genes/v1/3691/patents?page=2