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Gene · 3693

ITGB5: integrin subunit beta 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ITGB5: integrin subunit beta 5. Genes, record 3693. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3693

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Gene

Symbol
ITGB5
HGNC
Name
integrin subunit beta 5
HGNC
NCBI Gene ID
3693
NCBI Gene
HGNC ID
HGNC:6160
HGNC
Ensembl
ENSG00000082781
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P18084Integrin beta-57993Ensembl, GeneID, HGNC

Source UniProt

Patents51

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-193695P18084Espacenet
JP 2025529142 A2025-09-042152P18084Espacenet
US 12371689 B22025-07-292152P18084Espacenet
JP 2025517970 A2025-06-123695P18084Espacenet
US 12291562 B22025-05-0612P18084Espacenet
JP 2025032204 A2025-03-1130101P18084Espacenet
KR 1020240176122 A2024-12-244P18084Espacenet
WO 2024252368 A22024-12-12140P18084Espacenet
EP 4461818 A22024-11-1330101P18084Espacenet
EP 4458349 A12024-11-0614P18084Espacenet

1 to 10 of 51

See all 51 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABITUZUMABCHEMBL2109621Integrin alpha-V/beta-5 inhibitorINHIBITORChEMBL
CILENGITIDECHEMBL429876Integrin alpha-V/beta-5 antagonistANTAGONISTChEMBL
INTETUMUMABCHEMBL1743032Integrin alpha-V/beta-5 antagonistANTAGONISTChEMBL

Trials35

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03688230ABITUZUMABPHASE2ClinicalTrials.gov
NCT02745145ABITUZUMABPHASE22019-06-18ClinicalTrials.gov
NCT01782976CILENGITIDEPHASE2ClinicalTrials.gov
NCT01558687CILENGITIDEPHASE1ClinicalTrials.gov
NCT01517776CILENGITIDEPHASE2ClinicalTrials.gov
NCT01360840ABITUZUMABPHASE22015-12-14ClinicalTrials.gov
NCT01165333CILENGITIDEPHASE1ClinicalTrials.gov
NCT01124240CILENGITIDEPHASE2ClinicalTrials.gov
NCT01122888CILENGITIDEPHASE1ClinicalTrials.gov
NCT01118676CILENGITIDEPHASE1ClinicalTrials.gov

1 to 10 of 35

See all 35 trials

NIH grants1,418

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleITGB5 papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
P30CA016672Cancer Center Support Grant72025
P30CA016056Roswell Park Cancer Center Support Grant62025
P30CA076292Moffitt Cancer Center Support Grant52025
R01NS121934Label-free Optical Recording of Neuroelectric Activities42025
R35GM141598Nanoscale probes for sensing molecular functions in live cells42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA016087Cancer Center Support Grant32025
P30CA033572Cancer Center Support Grant32025
P30ES006694Southwest Environmental Health Sciences Center32025

1 to 10 of 1,418Source NIH's project files

See all 1,418 nih grants

Papers1,722

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated Multi-Omics and Radiogenomic Analysis Identifies S100B and ITGB5 as Complementary Candidate Biomarkers of Glioblastoma Heterogeneity.Chem Biol Drug Des202642740387PubTator, text miningPubMed
Galectin-1 Modulates Cell Adhesions, Cavin-1 Phosphorylation, and Vascular Permeability in Kidney Endothelial Cells-Insights From Proteomics, Phosphoproteomics, and Functional Studies.Mol Cell Proteomics202642692155PubTator, text miningPubMed
Predicting Relevant Microglia-Associated Cell-Cell Communication Pathways in Alzheimer's Disease: A Role for SPP1.Glia202642552722PubTator, text miningPubMed
Retraction notice to "Molecular and cellular mechanisms of PDAC progression based on RETN-CAP1-mediated macrophage-fibroblast crosstalk: Action of ITGB5 and ITGB1 recombinant proteins" [Int. J. Biol. Macromol. 290 (2025) 139078].
Int J Biol Macromol202642527175PubTator, text miningPubMed
Transcriptome-wide m6A Methylation Profiling Reveals Regulatory Networks During Endothelial Differentiation of Bone Marrow Mesenchymal Stem Cells.Clin Appl Thromb Hemost202642501017PubTator, text miningPubMed
FKBP10 may affect the malignant phenotype of oral squamous cell carcinoma cells through the ECM/WNT signaling pathway.Sci Rep202642471471PubTator, text miningPubMed
Decoding Preeclampsia and Obesity: The Role of Immune Responses and Natural Product Interventions.Endocr Metab Immune Disord Drug Targets202642446026PubTator, text miningPubMed
Circulating mRNA and miRNA Signatures Used as Predictive Markers of Lifestyle Modification Outcomes in Pediatric Obesity Management.Horm Res Paediatr202642391183PubTator, text miningPubMed
A HRH1-YAP1 feedback loop drives pancreatic cancer progression and predicts therapeutic response.Oncol Lett202642383289PubTator, text miningPubMed
Increased induced sputum ITGB5 expression was correlated with airway inflammation and lung function in asthma.J Asthma202642370849PubTator, text miningPubMed

1 to 10 of 1,722

See all 1,722 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3693

GET https://conductscience.org/api/genes/v1/3693/patents?page=2