Gene · 3693
ITGB5: integrin subunit beta 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ITGB5: integrin subunit beta 5. Genes, record 3693. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3693
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P18084 | Integrin beta-5 | 799 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents51
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 3695 | P18084 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2152 | P18084 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2152 | P18084 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3695 | P18084 | Espacenet |
| US 12291562 B2 | 2025-05-06 | 12 | P18084 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30101 | P18084 | Espacenet |
| KR 1020240176122 A | 2024-12-24 | 4 | P18084 | Espacenet |
| WO 2024252368 A2 | 2024-12-12 | 140 | P18084 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 30101 | P18084 | Espacenet |
| EP 4458349 A1 | 2024-11-06 | 14 | P18084 | Espacenet |
1 to 10 of 51
See all 51 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials35
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT03688230 | ABITUZUMAB | PHASE2 | ClinicalTrials.gov | |
| NCT02745145 | ABITUZUMAB | PHASE2 | 2019-06-18 | ClinicalTrials.gov |
| NCT01782976 | CILENGITIDE | PHASE2 | ClinicalTrials.gov | |
| NCT01558687 | CILENGITIDE | PHASE1 | ClinicalTrials.gov | |
| NCT01517776 | CILENGITIDE | PHASE2 | ClinicalTrials.gov | |
| NCT01360840 | ABITUZUMAB | PHASE2 | 2015-12-14 | ClinicalTrials.gov |
| NCT01165333 | CILENGITIDE | PHASE1 | ClinicalTrials.gov | |
| NCT01124240 | CILENGITIDE | PHASE2 | ClinicalTrials.gov | |
| NCT01122888 | CILENGITIDE | PHASE1 | ClinicalTrials.gov | |
| NCT01118676 | CILENGITIDE | PHASE1 | ClinicalTrials.gov |
1 to 10 of 35
See all 35 trialsNIH grants1,418
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ITGB5 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 6 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 5 | 2025 |
| R01NS121934 | Label-free Optical Recording of Neuroelectric Activities | 4 | 2025 |
| R35GM141598 | Nanoscale probes for sensing molecular functions in live cells | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 3 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 3 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 3 | 2025 |
1 to 10 of 1,418Source NIH's project files
See all 1,418 nih grantsPapers1,722
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrated Multi-Omics and Radiogenomic Analysis Identifies S100B and ITGB5 as Complementary Candidate Biomarkers of Glioblastoma Heterogeneity. | Chem Biol Drug Des | 2026 | 42740387 | PubTator, text mining | PubMed |
| Galectin-1 Modulates Cell Adhesions, Cavin-1 Phosphorylation, and Vascular Permeability in Kidney Endothelial Cells-Insights From Proteomics, Phosphoproteomics, and Functional Studies. | Mol Cell Proteomics | 2026 | 42692155 | PubTator, text mining | PubMed |
| Predicting Relevant Microglia-Associated Cell-Cell Communication Pathways in Alzheimer's Disease: A Role for SPP1. | Glia | 2026 | 42552722 | PubTator, text mining | PubMed |
Retraction notice to "Molecular and cellular mechanisms of PDAC progression based on RETN-CAP1-mediated macrophage-fibroblast crosstalk: Action of ITGB5 and ITGB1 recombinant proteins" [Int. J. Biol. Macromol. 290 (2025) 139078]. | Int J Biol Macromol | 2026 | 42527175 | PubTator, text mining | PubMed |
| Transcriptome-wide m6A Methylation Profiling Reveals Regulatory Networks During Endothelial Differentiation of Bone Marrow Mesenchymal Stem Cells. | Clin Appl Thromb Hemost | 2026 | 42501017 | PubTator, text mining | PubMed |
| FKBP10 may affect the malignant phenotype of oral squamous cell carcinoma cells through the ECM/WNT signaling pathway. | Sci Rep | 2026 | 42471471 | PubTator, text mining | PubMed |
| Decoding Preeclampsia and Obesity: The Role of Immune Responses and Natural Product Interventions. | Endocr Metab Immune Disord Drug Targets | 2026 | 42446026 | PubTator, text mining | PubMed |
| Circulating mRNA and miRNA Signatures Used as Predictive Markers of Lifestyle Modification Outcomes in Pediatric Obesity Management. | Horm Res Paediatr | 2026 | 42391183 | PubTator, text mining | PubMed |
| A HRH1-YAP1 feedback loop drives pancreatic cancer progression and predicts therapeutic response. | Oncol Lett | 2026 | 42383289 | PubTator, text mining | PubMed |
| Increased induced sputum ITGB5 expression was correlated with airway inflammation and lung function in asthma. | J Asthma | 2026 | 42370849 | PubTator, text mining | PubMed |
1 to 10 of 1,722
See all 1,722 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3693
GET https://conductscience.org/api/genes/v1/3693/patents?page=2