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Gene · 3694

ITGB6: integrin subunit beta 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ITGB6: integrin subunit beta 6. Genes, record 3694. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3694

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Gene

Symbol
ITGB6
HGNC
Name
integrin subunit beta 6
HGNC
NCBI Gene ID
3694
NCBI Gene
HGNC ID
HGNC:6161
HGNC
Ensembl
ENSG00000115221
NCBI Gene
Aliases
AI1H
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P18564Integrin beta-678814Ensembl, GeneID, HGNC

Source UniProt

Patents119

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449988P18564Espacenet
JP 2026004568 A2026-01-1449989P18564Espacenet
WO 2025253854 A2025-12-112P18564Espacenet
EP 4650780 A22025-11-193198P18564Espacenet
WO 2025228986 A12025-11-066P18564Espacenet
EP 4644537 A12025-11-056P18564Espacenet
EP 4641201 A22025-10-292764P18564Espacenet
EP 4633740 A22025-10-22857P18564Espacenet
EP 4631545 A12025-10-152P18564Espacenet
WO 2025199077 A12025-09-25185P18564Espacenet

1 to 10 of 119

See all 119 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABITUZUMABCHEMBL2109621Integrin alpha-V/beta-6 inhibitorINHIBITORChEMBL
SIGVOTATUGCHEMBL5314878Integrin beta-6 inhibitorINHIBITORChEMBL
SIGVOTATUG VEDOTINCHEMBL5314879Integrin beta-6 binding agentBINDING AGENTChEMBL
STX-100CHEMBL2109623Integrin alpha-V/beta-6 inhibitorINHIBITORChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07227298SIGVOTATUG VEDOTINPHASE1/PHASE2ClinicalTrials.gov
NCT06758401SIGVOTATUG VEDOTINPHASE3ClinicalTrials.gov
NCT06012435SIGVOTATUG VEDOTINPHASE3ClinicalTrials.gov
NCT03688230ABITUZUMABPHASE2ClinicalTrials.gov
NCT03573505STX-100PHASE22020-11-20ClinicalTrials.gov
NCT02745145ABITUZUMABPHASE22019-06-18ClinicalTrials.gov
NCT01371305STX-100PHASE22020-02-28ClinicalTrials.gov
NCT01360840ABITUZUMABPHASE22015-12-14ClinicalTrials.gov
NCT01008475ABITUZUMABPHASE1/PHASE22016-03-30ClinicalTrials.gov
NCT00958477ABITUZUMABPHASE12017-08-02ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants1,044

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleITGB6 papersNewest fiscal year
P30CA068485Cancer Center Support Grant52025
P30CA008748Cancer Center Support Grant42025
P30CA093373Cancer Center Support Grant P3042025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA010815Consolidated Basic Cancer Research Program32025
P30CA015704Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
P30CA077598Cancer Center Support Grant32025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION32025
R01HL127349Genomic Analysis of Tissue and Cellular Heterogeneity in IPF32025

1 to 10 of 1,044Source NIH's project files

See all 1,044 nih grants

Papers1,301

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Role of Integrin Family in Atherosclerotic Cardiovascular Disease: A Prospective Cohort Study and Mendelian Randomization Analysis.Biomedicines202642652217PubTator, text miningPubMed
Integrin β6-Targeted CAR-T Cells exhibit potent antitumor activity in β6-Positive pancreatic ductal adenocarcinoma and lung adenocarcinoma.Mol Cancer Ther202642594406PubTator, text miningPubMed
Tetrandrine-loaded phenylboronic acid-chitosan nanoparticles for enhanced corneal penetration and anti-fibrotic therapy.Int J Pharm202642567377PubTator, text miningPubMed
PF-08046876, a differentiated integrin beta-6 antibody-drug conjugate delivering a potent camptothecin payload optimized for bystander effect and reduced drug efflux.Mol Cancer Ther202642515977PubTator, text miningPubMed
Stanniocalcin 1 promotes gastric cancer progression by activating the PI3K/AKT pathway and inducing M2 macrophage polarization via the JAK2/STAT3/lL-10 axis.Chin Med J (Engl)202642484012PubTator, text miningPubMed
Advances in antibody-drug conjugate-based combination therapy strategies for non-small cell lung cancer.Expert Opin Biol Ther202642467409PubTator, text miningPubMed
Long-term ocular symptoms following COVID-19 linked to immune dysregulation, dysautonomia and peripheral neuropathy.Nat Commun202642420292PubTator, text miningPubMed
Distinct motility and pro-fibrotic effect of renal tubule-derived extracellular vesicles in fibrotic extracellular matrix.Acta Biomater202642413712PubTator, text miningPubMed
LLPS-based classification and a novel prognostic signature reveal NRF1 as a therapeutic target in pancreatic cancer.Cancer Cell Int202642363116PubTator, text miningPubMed
Sex-based differences in tolerability of developmental antibody-drug conjugates (ADCs) in non-small-cell lung cancer (NSCLC).ESMO Open202642330841PubTator, text miningPubMed

1 to 10 of 1,301

See all 1,301 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3694

GET https://conductscience.org/api/genes/v1/3694/patents?page=2