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Gene · 3702

ITK: IL2 inducible T cell kinase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ITK: IL2 inducible T cell kinase. Genes, record 3702. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3702

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Gene

Symbol
ITK
HGNC
Name
IL2 inducible T cell kinase
HGNC
NCBI Gene ID
3702
NCBI Gene
HGNC ID
HGNC:6171
HGNC
Ensembl
ENSG00000113263
NCBI Gene
Aliases
EMT, LPFS1, LYK, PSCTK2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q08881Tyrosine-protein kinase ITK/TSK62037Ensembl, GeneID, HGNC

Source UniProt

Patents88

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449624Q08881Espacenet
EP 4661970 A12025-12-1762154Q08881Espacenet
EP 4641201 A22025-10-2914476Q08881Espacenet
JP 2025517969 A2025-06-1214476Q08881Espacenet
US 12006548 B22024-06-11395Q08881Espacenet
US 11446398 B22022-09-2039528Q08881Espacenet
US 11351168 B12022-06-073Q08881Espacenet
JP 2022524081 A2022-04-27142499Q08881Espacenet
US 11078247 B22021-08-035638Q08881Espacenet
US 11015221 B22021-05-25100Q08881Espacenet

1 to 10 of 88

See all 88 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PAZOPANIBCHEMBL477772Tyrosine-protein kinase ITK/TSK inhibitorINHIBITORChEMBL
PAZOPANIB HYDROCHLORIDECHEMBL1201733Tyrosine-protein kinase ITK/TSK inhibitorINHIBITORChEMBL
RITLECITINIBCHEMBL4085457TEC family kinase inhibitorINHIBITORChEMBL
RITLECITINIB TOSYLATECHEMBL5314649TEC family kinase inhibitorINHIBITORChEMBL

Trials235

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07444619PAZOPANIBPHASE1ClinicalTrials.gov
NCT07228390RITLECITINIBPHASE2ClinicalTrials.gov
NCT07226531RITLECITINIBClinicalTrials.gov
NCT07200128RITLECITINIBClinicalTrials.gov
NCT07152626RITLECITINIBPHASE2ClinicalTrials.gov
NCT07152119RITLECITINIB TOSYLATEClinicalTrials.gov
NCT07087158PAZOPANIBPHASE2ClinicalTrials.gov
NCT07029828RITLECITINIBPHASE3ClinicalTrials.gov
NCT07029711RITLECITINIBPHASE3ClinicalTrials.gov
NCT06873945RITLECITINIBPHASE3ClinicalTrials.gov

1 to 10 of 235

See all 235 trials

NIH grants1,876

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleITK papersNewest fiscal year
P30CA008748Cancer Center Support Grant392025
R01AI043957Structural Studies of a T cell Specific Tyrosine Kinase352025
P30CA016672Cancer Center Support Grant242025
P30CA016058Cancer Center Support Grant162025
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR112025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success92025
P30CA076292Moffitt Cancer Center Support Grant82025
R01CA177292Targeted Therapies for Lymphoid Malignancies82025
ZIAHL002346Tumor microenvironment in CLL and MCL: pathogenesis, targets, and therapy82025
ZIABC010304Biochemical Basis of T Cell Activation62025

1 to 10 of 1,876Source NIH's project files

See all 1,876 nih grants

Papers2,789

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Corrigendum to "Purification and characterization of full-length monomeric TEC family kinase, ITK" [Protein Expr. Purif. 229 (2025) 106682].Protein Expr Purif202742575776PubTator, text miningPubMed
Mechanism and Individualized Management of Hypertension Associated With Bruton Tyrosine Kinase Inhibitors: The PCSK9/Notch3 Signaling Pathway.Front Biosci (Landmark Ed)202642811994PubTator, text miningPubMed
A multi-omics integrative analyses reveals CYBB-mediated apoptotic and immune dysregulation as a key target of berberine in diffuse large B-cell lymphoma.Front Pharmacol202642730162PubTator, text miningPubMed
Spectrum of Primary Hemophagocytic Lymphohistiocytosis-Associated Gene Mutations in Chinese Patients.MedComm (2020)202642688879PubTator, text miningPubMed
C-terminal CD28 phosphorylation, pY218, modulates IL-2 secretion and therapeutic effect of CAR-T cells.Mol Ther202642642932PubTator, text miningPubMed
Phase 1 Trial with Soquelitinib, a Selective ITK Inhibitor for Treatment of Relapsed/Refractory T Cell Lymphomas.Blood202642640855PubTator, text miningPubMed
Design, synthesis, and biological evaluation of novel 4-aminoquinoline benzoyl hydrazine derivatives as noncovalent BTK inhibitors for hematologic malignancies.Eur J Med Chem202642566884PubTator, text miningPubMed
Randomized phase 2a study of TAS5315, a Bruton's tyrosine kinase inhibitor, for chronic spontaneous urticaria.Allergol Int202642448553PubTator, text miningPubMed
Riding toward Selectivity: Optimization of Covalent 7-Azaindole-Based BMX Kinase Inhibitors.J Med Chem202642441922PubTator, text miningPubMed
Inhibition of the ZEB1-BCL2 axis in cancer-associated fibroblasts as a strategy to improve chemotherapy response in intrahepatic cholangiocarcinoma.Biomed Pharmacother202642407325PubTator, text miningPubMed

1 to 10 of 2,789

See all 2,789 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3702

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