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Gene · 3704

ITPA: inosine triphosphatase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ITPA: inosine triphosphatase. Genes, record 3704. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3704

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Gene

Symbol
ITPA
HGNC
Name
inosine triphosphatase
HGNC
NCBI Gene ID
3704
NCBI Gene
HGNC ID
HGNC:6176
HGNC
Ensembl
ENSG00000125877
NCBI Gene
Aliases
C20orf37, DEE35, HLC14-06-P, ITPase, My049, NTPase, dJ794I6.3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9BY32Inosine triphosphate pyrophosphatase1944Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449791Q9BY32Espacenet
EP 4650780 A22025-11-1910271Q9BY32Espacenet
EP 4640849 A22025-10-291552Q9BY32Espacenet
EP 4641201 A22025-10-2910579Q9BY32Espacenet
JP 2025519096 A2025-06-241552Q9BY32Espacenet
JP 2025517969 A2025-06-1210579Q9BY32Espacenet
JP 2025517970 A2025-06-1210271Q9BY32Espacenet
US 11446398 B22022-09-2040317Q9BY32Espacenet
JP 2022524081 A2022-04-27143288Q9BY32Espacenet
US 11047010 B22021-06-293062Q9BY32Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants875

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleITPA papersNewest fiscal year
R01AI087856MECHANISM OF RNA SYNTHESIS BY DENGUE VIRUS NS552025
R01AI094386Genome structure, transcription and packaging of dsRNA viruses52025
R01GM071940High-Resolution CryoEM Reconstruction of Large Complexes52025
ZIALM000061Finding Protein Sequence Motifs--Methods And Applications52025
P30AI050409Center for AIDS Research at Emory University42025
P30CA036727Buffett Cancer Center Support Grant42025
R01AI036040STRUCTURAL STUDIES ON ROTAVIRUS42025
ZIAAI000897Noroviruses and Epidemic Gastroenteritis42025
P20GM103427Nebraska Research Network in Functional Genomics32025
P30CA021765Cancer Center Support Grant (CCSG)32025

1 to 10 of 875Source NIH's project files

See all 875 nih grants

Papers2,079

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SAMD9/9L Innate Immunity: Antiviral Mechanisms and Evolutionary Trade-Offs of Multidomain Proteins.Annu Rev Virol202642791213PubTator, text miningPubMed
Flavivirus NS1 possesses NTPase and RNA helix unwinding activities.Virol Sin202642753873PubTator, text miningPubMed
Structure-based virtual screening leads to the discovery of a 4,5-dihydropyrazole derivative as the first dual inhibitor of West Nile virus NS3 helicase and protease.Eur J Med Chem202642691700PubTator, text miningPubMed
Genetic variants in purine metabolism and treatment resistance in schizophrenia: evidence supporting the adenosine hypothesis - a pilot study.Front Pharmacol202642582614PubTator, text miningPubMed
Guanylate kinase 1 is an enzyme responsible for inosine accumulation in RNA of mammalian cells deficient in inosine triphosphatase.Proc Natl Acad Sci U S A202642531025PubTator, text miningPubMed
Genetic heterogeneity, movement disorders, and white matter abnormalities in pediatric developmental and epileptic encephalopathies: A retrospective cohort study from a National Neurodegenerative and Leukodystrophy Registry.
Epilepsy Res202642407302PubTator, text miningPubMed
Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems.Nucleic Acids Res202642258539PubTator, text miningPubMed
Chikungunya virus nsP2: Insights into viral replication, pathogenesis, and therapeutic targeting.Virulence202642178977PubTator, text miningPubMed
Association of Variants in Candidate Pharmacogenes with Response to Mercaptopurine and Methotrexate in Pediatric Acute Lymphoblastic Leukemia: A Single-Center Experience from Croatia.Oncol Ther202642168754PubTator, text miningPubMed
Nuclease-NTPase antiphage defence systems use conserved molecular features to control bacterial immunity.Nat Microbiol202642045369PubTator, text miningPubMed

1 to 10 of 2,079

See all 2,079 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3704

GET https://conductscience.org/api/genes/v1/3704/patents?page=2