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Gene · 3708

ITPR1: inositol 1,4,5-trisphosphate receptor type 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ITPR1: inositol 1,4,5-trisphosphate receptor type 1. Genes, record 3708. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3708

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Gene

Symbol
ITPR1
HGNC
Name
inositol 1,4,5-trisphosphate receptor type 1
HGNC
NCBI Gene ID
3708
NCBI Gene
HGNC ID
HGNC:6180
HGNC
Ensembl
ENSG00000150995
NCBI Gene
Aliases
ACV, CLA4, INSP3R1, IP3R, IP3R1, Insp3r1, PPP1R94, SCA15, SCA16, SCA29
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14643Inositol 1,4,5-trisphosphate-gated calcium channel ITPR12,7580Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449796Q14643Espacenet
EP 4641201 A22025-10-2925407Q14643Espacenet
JP 2025529142 A2025-09-042159Q14643Espacenet
US 12371689 B22025-07-292159Q14643Espacenet
JP 2025517969 A2025-06-1225407Q14643Espacenet
JP 2025032204 A2025-03-1130008Q14643Espacenet
JP 2025032204 A2025-03-1130014Q14643Espacenet
EP 4461818 A22024-11-1330008Q14643Espacenet
EP 4461818 A22024-11-1330014Q14643Espacenet
JP 2023548973 A2023-11-21245Q14643Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,123

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleITPR1 papersNewest fiscal year
R01DE014756Ca2+ and secretory dynamics in salivary acinar cells292025
P30DK034989Yale Liver Center182025
R01DE019245An experimental/computational approach for understanding salivary fluid secretion152025
UL1TR001863Yale Clinical and Translational Science Award112025
ZIADE000438Molecular Mechanisms Regulating Calcium Flux In Salivary Glands72025
P30CA168524The University of Kansas Cancer Center42025
R01MH101221Rare Mutations and Autism Spectrum Disorders42025
R01NS124854Targeting Cerebellar Endoplasmic Reticulum Calcium Handling in Essential Tremor42025
P30CA008748Cancer Center Support Grant32025
P30CA030199Cancer Center Support Grant (CCSG)32025

1 to 10 of 2,123Source NIH's project files

See all 2,123 nih grants

Papers3,280

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A programmable spatiotemporal bioelectrical conduit promotes peripheral nerve regeneration by suppressing ferroptosis through modulation of ER-mitochondria coupling in Schwann cells.Bioact Mater202742781229PubTator, text miningPubMed
A novel minimally invasive diagnostic approach of various brain malignancies based on differential miRNA expression.J Neurooncol202642809056PubTator, text miningPubMed
Mitochondrial Ca2+ homeostasis in ovarian function and oocyte competence: from molecular transporters to early embryonic development.Front Cell Dev Biol202642798439PubTator, text miningPubMed
DISC1 Orchestrates Mitochondrial Calcium Overload in Diabetic Encephalopathy Through a Dual Nucleocytoplasmic Mechanism.Biomolecules202642793198PubTator, text miningPubMed
Obesity associated elevated leptin might contribute to paclitaxel resistance via PLCB1/IP3R1 axis in head and neck cancers.Biochim Biophys Acta Mol Basis Dis202642772703PubTator, text miningPubMed
Potential of sweetener substitutes to circumvent metabolic dysfunction-associated steatotic liver disease and hepatic fibrosis risk: Integrating network toxicology and validation in vitro.Food Chem Toxicol202642732869PubTator, text miningPubMed
Retinoic acid-related orphan receptor alpha (RORα) as a candidate multi-pathway target in Alzheimer's disease: mechanisms and therapeutic prospects.Front Neurosci202642694676PubTator, text miningPubMed
Circulating excitation-contraction coupling proteins and incident cardiovascular outcomes: associations and incremental predictive performance in the UK Biobank.Front Cardiovasc Med202642656608PubTator, text miningPubMed
Senecavirus a 3C protease cleaves RETREG1 to antagonize ER-phagy and promote viral replication via endoplasmic reticulum calcium signaling.Autophagy202642576627PubTator, text miningPubMed
SARS-CoV-2 nucleocapsid protein drives pulmonary injury by enhancing GRP75-dependent ER-mitochondria tethering and reprogramming of alveolar macrophages.Life Sci202642570816PubTator, text miningPubMed

1 to 10 of 3,280

See all 3,280 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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