Gene · 3713
IVL: involucrin
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IVL: involucrin. Genes, record 3713. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3713
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P07476 | Involucrin | 585 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents28
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 50365 | P07476 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8667 | P07476 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8667 | P07476 | Espacenet |
| US 12024722 B2 | 2024-07-02 | 420 | P07476 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 41908 | P07476 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 144879 | P07476 | Espacenet |
| JP 2022022849 A | 2022-02-07 | 10 | P07476 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 5654 | P07476 | Espacenet |
| KR 1020210048435 A | 2021-05-03 | 4 | P07476 | Espacenet |
| US 10935548 B2 | 2021-03-02 | 12 | P07476 | Espacenet |
1 to 10 of 28
See all 28 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,524
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IVL papers | Newest fiscal year |
|---|---|---|---|
| P30CA134274 | UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT | 16 | 2025 |
| P01CA022443 | Molecular Biology and Genetics of Human Tumor Viruses | 10 | 2025 |
| P30DK050306 | Center for Molecular Studies in Digestive and Liver Diseases | 10 | 2025 |
| P30AR069589 | Penn Skin Biology and Diseases Resource-based Center | 8 | 2025 |
| P30DK078392 | Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease | 7 | 2025 |
| U19AI070235 | Epithelial Genes in Allergic Inflammation | 7 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 6 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 6 | 2025 |
| R01AR066530 | Regulators of epidermal growth and differentiation | 6 | 2025 |
| R01AR073004 | Mechanism of action and function of novel secosteroid 20(OH)D3 in the skin | 6 | 2025 |
1 to 10 of 1,524Source NIH's project files
See all 1,524 nih grantsPapers3,772
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Pedunculoside alleviates cheilitis-like inflammation by suppressing the TLR3/TRIF/NF-κB signaling. | Int Immunopharmacol | 2026 | 42805066 | PubTator, text mining | PubMed |
| Anoectochilus roxburghii extract alleviates inflammation and restores skin barrier function in vitro and in vivo. | Fitoterapia | 2026 | 42800590 | PubTator, text mining | PubMed |
| ML281 Does Not Function as an STK33 Inhibitor but Modulates Proliferation and Differentiation of Keratinocytes Derived from Hypertrophic Scars. | Int J Mol Sci | 2026 | 42794700 | PubTator, text mining | PubMed |
| Dynamic flow-driven in vitro skin model reveals mechanosensitive remodeling pathways. | Hum Cell | 2026 | 42789213 | PubTator, text mining | PubMed |
| Lipoic acid synthase modulates psoriasis-like keratinocyte dysfunction in association with oxidative stress, ferroptosis-associated remodeling, and STAT3/NF-κB activation. | Naunyn Schmiedebergs Arch Pharmacol | 2026 | 42776206 | PubTator, text mining | PubMed |
| A Subcellular Keap1-Nrf2 Disruption Strategy for Atopic Dermatitis Therapy. | J Med Chem | 2026 | 42720490 | PubTator, text mining | PubMed |
| Enzymatically Hydrolyzed Eggshell Membrane Promotes Keratinocyte Differentiation Associated With PKC and Akt Signaling Pathways. | J Food Sci | 2026 | 42644214 | PubTator, text mining | PubMed |
| Direct Effects of 308-nm Excimer Light on Keratinocyte Proliferation and Differentiation in Human Organ-Cultured Skin. | Int J Mol Sci | 2026 | 42589355 | PubTator, text mining | PubMed |
| Repetin Regulates Epidermal Barrier Homeostasis and Is Associated With Inflammatory Skin Diseases. | Exp Dermatol | 2026 | 42544840 | PubTator, text mining | PubMed |
| [Evaluation of the skin barrier repair function and anti-inflammatory activity of recombinant mussel mucin Mfp151]. | Sheng Wu Gong Cheng Xue Bao | 2026 | 42522623 | PubTator, text mining | PubMed |
1 to 10 of 3,772
See all 3,772 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3713
GET https://conductscience.org/api/genes/v1/3713/patents?page=2