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Gene · 3713

IVL: involucrin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IVL: involucrin. Genes, record 3713. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3713

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Gene

Symbol
IVL
HGNC
Name
involucrin
HGNC
NCBI Gene ID
3713
NCBI Gene
HGNC ID
HGNC:6187
HGNC
Ensembl
ENSG00000163207
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07476Involucrin5850Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450365P07476Espacenet
EP 4641201 A22025-10-298667P07476Espacenet
JP 2025517969 A2025-06-128667P07476Espacenet
US 12024722 B22024-07-02420P07476Espacenet
US 11446398 B22022-09-2041908P07476Espacenet
JP 2022524081 A2022-04-27144879P07476Espacenet
JP 2022022849 A2022-02-0710P07476Espacenet
US 11078247 B22021-08-035654P07476Espacenet
KR 1020210048435 A2021-05-034P07476Espacenet
US 10935548 B22021-03-0212P07476Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,524

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIVL papersNewest fiscal year
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT162025
P01CA022443Molecular Biology and Genetics of Human Tumor Viruses102025
P30DK050306Center for Molecular Studies in Digestive and Liver Diseases102025
P30AR069589Penn Skin Biology and Diseases Resource-based Center82025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease72025
U19AI070235Epithelial Genes in Allergic Inflammation72025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant62025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center62025
R01AR066530Regulators of epidermal growth and differentiation62025
R01AR073004Mechanism of action and function of novel secosteroid 20(OH)D3 in the skin62025

1 to 10 of 1,524Source NIH's project files

See all 1,524 nih grants

Papers3,772

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Pedunculoside alleviates cheilitis-like inflammation by suppressing the TLR3/TRIF/NF-κB signaling.Int Immunopharmacol202642805066PubTator, text miningPubMed
Anoectochilus roxburghii extract alleviates inflammation and restores skin barrier function in vitro and in vivo.Fitoterapia202642800590PubTator, text miningPubMed
ML281 Does Not Function as an STK33 Inhibitor but Modulates Proliferation and Differentiation of Keratinocytes Derived from Hypertrophic Scars.Int J Mol Sci202642794700PubTator, text miningPubMed
Dynamic flow-driven in vitro skin model reveals mechanosensitive remodeling pathways.Hum Cell202642789213PubTator, text miningPubMed
Lipoic acid synthase modulates psoriasis-like keratinocyte dysfunction in association with oxidative stress, ferroptosis-associated remodeling, and STAT3/NF-κB activation.Naunyn Schmiedebergs Arch Pharmacol202642776206PubTator, text miningPubMed
A Subcellular Keap1-Nrf2 Disruption Strategy for Atopic Dermatitis Therapy.J Med Chem202642720490PubTator, text miningPubMed
Enzymatically Hydrolyzed Eggshell Membrane Promotes Keratinocyte Differentiation Associated With PKC and Akt Signaling Pathways.J Food Sci202642644214PubTator, text miningPubMed
Direct Effects of 308-nm Excimer Light on Keratinocyte Proliferation and Differentiation in Human Organ-Cultured Skin.Int J Mol Sci202642589355PubTator, text miningPubMed
Repetin Regulates Epidermal Barrier Homeostasis and Is Associated With Inflammatory Skin Diseases.Exp Dermatol202642544840PubTator, text miningPubMed
[Evaluation of the skin barrier repair function and anti-inflammatory activity of recombinant mussel mucin Mfp151].Sheng Wu Gong Cheng Xue Bao202642522623PubTator, text miningPubMed

1 to 10 of 3,772

See all 3,772 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3713

GET https://conductscience.org/api/genes/v1/3713/patents?page=2