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Gene · 3714

JAG2: jagged canonical Notch ligand 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. JAG2: jagged canonical Notch ligand 2. Genes, record 3714. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3714

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Gene

Symbol
JAG2
HGNC
Name
jagged canonical Notch ligand 2
HGNC
NCBI Gene ID
3714
NCBI Gene
HGNC ID
HGNC:6189
HGNC
Ensembl
ENSG00000184916
NCBI Gene
Aliases
HJ2, LGMDR27, SER2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y219Protein jagged-21,2383Ensembl, GeneID, HGNC

Source UniProt

Patents68

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12570741 B22026-03-1016Q9Y219Espacenet
JP 2026004568 A2026-01-1450469Q9Y219Espacenet
EP 4650780 A22025-11-195758Q9Y219Espacenet
WO 2025228986 A12025-11-0626Q9Y219Espacenet
EP 4644537 A12025-11-0526Q9Y219Espacenet
EP 4641201 A22025-10-295422Q9Y219Espacenet
JP 2025529142 A2025-09-042171Q9Y219Espacenet
US 12371689 B22025-07-292171Q9Y219Espacenet
JP 2025517969 A2025-06-125422Q9Y219Espacenet
JP 2025517970 A2025-06-125758Q9Y219Espacenet

1 to 10 of 68

See all 68 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,965

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleJAG2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant202025
P30CA008748Cancer Center Support Grant112025
P30CA006973Regional Oncology Research Center72025
P30CA016058Cancer Center Support Grant62025
P30CA016087Cancer Center Support Grant62025
P30CA046934University of Colorado Cancer Center Support Grant62025
U54CA1186381/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership62025
P30CA086862Cancer Center Support Grant52025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)52025
P30CA034196Cancer Center Support (CORE) Grant42025

1 to 10 of 1,965Source NIH's project files

See all 1,965 nih grants

Papers2,693

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
One Ligand, Two Messages: How JAG2 Reconciles Self-Renewal and Differentiation in Muscle Stem Cells.Stem Cell Rev Rep202642696101PubTator, text miningPubMed
Genome-wide chromatin recording resolves dynamic cell state changes.Cell Syst202642685696PubTator, text miningPubMed
Nuclear speckle-associated perispeckle networks partition active chromatin into gene expression niches.Cell Rep202642603274PubTator, text miningPubMed
Evolution-guided yeast complementation reveals functional differences in human PSPH variants.FEBS Open Bio202642552870PubTator, text miningPubMed
Spatial mapping of Notch signaling components along the bull genital tract and in epididymal and vas deferens vesicles.Anim Reprod Sci202642447766PubTator, text miningPubMed
Inhibiting METTL3 synergizes with Notch blockade to treat ESCC by targeting cancer stemness via m6A-JAG2.J Gastroenterol202642274788PubTator, text miningPubMed
[Expression of Notch signaling pathway in children with Henoch-Schönlein purpura and its correlation with inflam-matory cytokines].Zhejiang Da Xue Xue Bao Yi Xue Ban202641946652PubTator, text miningPubMed
Tumor-derived JAG2 programs macrophages via NOTCH3 to drive perineural invasion in colorectal cancer.Int J Biol Macromol202641916520PubTator, text miningPubMed
The role of Notch signalling and its crosstalk with oestrogen receptor signalling in breast cancer.Cancer Metastasis Rev202641894035PubTator, text miningPubMed
Cell-Cell Interactome-Based Pathogenesis and Therapies for Osteosarcoma.Cells202641892359PubTator, text miningPubMed

1 to 10 of 2,693

See all 2,693 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3714

GET https://conductscience.org/api/genes/v1/3714/patents?page=2