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JAK1: Janus kinase 1

1 protein, 75 patents, 26 drugs, 993 trials, 6,899 NIH grants and 17,500 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolJAK1HGNC
NameJanus kinase 1HGNC
NCBI Gene ID3716NCBI Gene
HGNC IDHGNC:6190HGNC
EnsemblENSG00000162434NCBI Gene
AliasesAIIDE, JAK1A, JAK1B, JTK3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P23458Tyrosine-protein kinase JAK11,15452Ensembl, GeneID, HGNCUniProt

Patents 75

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0353P23458Espacenet
JP 2026004568 A2026-01-1450471P23458Espacenet
EP 4661970 A12025-12-1762155P23458Espacenet
EP 4650780 A22025-11-196790P23458Espacenet
EP 4641201 A22025-10-296586P23458Espacenet
JP 2025532979 A2025-10-0390P23458Espacenet
EP 4593850 A22025-08-0690P23458Espacenet
JP 2025517969 A2025-06-126586P23458Espacenet
JP 2025517970 A2025-06-126790P23458Espacenet
US 12295971 B22025-05-1390P23458Espacenet

Drugs 26

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABROCITINIBCHEMBL3655081Tyrosine-protein kinase JAK1 inhibitorINHIBITORChEMBL
BARICITINIBCHEMBL2105759Tyrosine-protein kinase JAK1 inhibitorINHIBITORChEMBL
BREPOCITINIBCHEMBL4297477Tyrosine-protein kinase JAK1 inhibitorINHIBITORChEMBL
CERDULATINIBCHEMBL4116008Tyrosine-protein kinase JAK1 inhibitorINHIBITORChEMBL
DELGOCITINIBCHEMBL4297507Janus Kinase (JAK) inhibitorINHIBITORChEMBL
DEURUXOLITINIB PHOSPHATECHEMBL4594382Tyrosine-protein kinase JAK1 inhibitorINHIBITORChEMBL
FILGOTINIBCHEMBL3301607Tyrosine-protein kinase JAK1 inhibitorINHIBITORChEMBL
FILGOTINIB MALEATECHEMBL4298167Tyrosine-protein kinase JAK1 inhibitorINHIBITORChEMBL
GLPG-0555CHEMBL3545249Tyrosine-protein kinase JAK1 inhibitorINHIBITORChEMBL
GOLIDOCITINIBCHEMBL4577523Tyrosine-protein kinase JAK1 inhibitorINHIBITORChEMBL

Trials 993

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07598643TOFACITINIBPHASE2ClinicalTrials.gov
NCT07597577UPADACITINIBClinicalTrials.gov
NCT07595939RUXOLITINIBPHASE3ClinicalTrials.gov
NCT07588568UPADACITINIBPHASE2ClinicalTrials.gov
NCT07581418TOFACITINIBClinicalTrials.gov
NCT07576010RUXOLITINIBPHASE1ClinicalTrials.gov
NCT07569081MOMELOTINIBPHASE2/PHASE3ClinicalTrials.gov
NCT07566897RUXOLITINIBPHASE1ClinicalTrials.gov
NCT07554820TOFACITINIBPHASE4ClinicalTrials.gov
NCT07554495FILGOTINIBPHASE3ClinicalTrials.gov

NIH grants 6899

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1622,025NIH's project files
P30CA008748Cancer Center Support Grant1022,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)502,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award352,025NIH's project files
P30CA016058Cancer Center Support Grant332,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant312,025NIH's project files
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success312,025NIH's project files
ZIAAR041159Cytokine Signaling, Immunoregulation and Autoimmune and Immunodeficiency Diseases242,025NIH's project files
P30CA006973Regional Oncology Research Center222,025NIH's project files
ZICAR041181Translational Immunology research: a support for clinical immunological research212,025NIH's project files

Papers 17500

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825998PubTator, text miningPubMed
42824469PubTator, text miningPubMed
42818232PubTator, text miningPubMed
42816545PubTator, text miningPubMed
42815591PubTator, text miningPubMed
42812068PubTator, text miningPubMed
42809123PubTator, text miningPubMed
42806494PubTator, text miningPubMed
42805114PubTator, text miningPubMed
42804788PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license