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Gene · 3735

KARS1: lysyl-tRNA synthetase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KARS1: lysyl-tRNA synthetase 1. Genes, record 3735. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3735

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Gene

Symbol
KARS1
HGNC
Name
lysyl-tRNA synthetase 1
HGNC
NCBI Gene ID
3735
NCBI Gene
HGNC ID
HGNC:6215
HGNC
Ensembl
ENSG00000065427
NCBI Gene
Aliases
CMTRIB, DEAPLE, DFNB89, KARS, KARS2, KRS, LEPID
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15046Lysine--tRNA ligase59714Ensembl, GeneID, HGNC

Source UniProt

Patents61

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19330Q15046Espacenet
JP 2026004568 A2026-01-1452182Q15046Espacenet
EP 4650780 A22025-11-194184Q15046Espacenet
JP 2025517970 A2025-06-124184Q15046Espacenet
JP 2024178415 A2024-12-248181Q15046Espacenet
WO 2024214081 A12024-10-17330Q15046Espacenet
US 11965038 B22024-04-23118Q15046Espacenet
US 11685791 B22023-06-2776Q15046Espacenet
US 11446398 B22022-09-2047972Q15046Espacenet
US 11378572 B22022-07-051Q15046Espacenet

1 to 10 of 61

See all 61 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants916

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKARS1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant42025
R01NS124547The mammalian multi-tRNA synthetase complex42025
R37AI050234Defining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug Resistance42025
P01CA100730Retrovirus Models of Cancer32025
P30AI027767UAB Center for AIDS Research (CFAR)32025
P30CA013148Comprehensive Cancer Center Support Grant32025
ZIAHG200359Genomic Ascertainment - Molecular and Genetic Aspects32025
ZIBHG000196Inter- and Intra-Species Comparative Sequencing32025
P01CA092584Structural Cell Biology of DNA Repair Machines22025
P30CA015704Cancer Center Support Grant22025

1 to 10 of 916Source NIH's project files

See all 916 nih grants

Papers1,650

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Aminoacyl-tRNA synthetases in tumor immunity: canonical translation, source-resolved immune circuits and therapeutic opportunities.Front Immunol202642769515PubTator, text miningPubMed
Neuropathologic Features of Adult-Onset Progressive Leukodystrophy Due to KARS Pathogenic Variants: A Case Report.Neurol Genet202642621967PubTator, text miningPubMed
In silico and in ovo model evaluation of thymol as an anticryptosporidial agent.Vet Parasitol202642600387PubTator, text miningPubMed
Electrochemiluminescence immunoassay for quantifying ZMA001 in human serum: method development, validation, and clinical pharmacokinetic application.Bioanalysis202642584159PubTator, text miningPubMed
Structural and Energetic Determinants of Monobody Recognition of Oncogenic KRAS Variants.bioRxiv202642465394PubTator, text miningPubMed
Utility of mimicking B cell epitopes between Mycobacterium leprae and host as prognostic biomarkers in type 1 reaction in leprosy.Sci Rep202642265262PubTator, text miningPubMed
Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.J Med Chem202642227818PubTator, text miningPubMed
[Role of Receptor Tyrosine Kinase AXL in Cancer Targeted Therapy Drug Resistance].Zhongguo Fei Ai Za Zhi202641916916PubTator, text miningPubMed
Expanding the Genetic Code with Lysine Aminoacylation.J Am Chem Soc202641834353PubTator, text miningPubMed
Translational regulation by oxidative desulfuration of tRNA modifications.Nat Commun202641807381PubTator, text miningPubMed

1 to 10 of 1,650

See all 1,650 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3735

GET https://conductscience.org/api/genes/v1/3735/patents?page=2