Gene · 3735
KARS1: lysyl-tRNA synthetase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KARS1: lysyl-tRNA synthetase 1. Genes, record 3735. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3735
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q15046 | Lysine--tRNA ligase | 597 | 14 | Ensembl, GeneID, HGNC |
Source UniProt
Patents61
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 330 | Q15046 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 52182 | Q15046 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4184 | Q15046 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4184 | Q15046 | Espacenet |
| JP 2024178415 A | 2024-12-24 | 8181 | Q15046 | Espacenet |
| WO 2024214081 A1 | 2024-10-17 | 330 | Q15046 | Espacenet |
| US 11965038 B2 | 2024-04-23 | 118 | Q15046 | Espacenet |
| US 11685791 B2 | 2023-06-27 | 76 | Q15046 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 47972 | Q15046 | Espacenet |
| US 11378572 B2 | 2022-07-05 | 1 | Q15046 | Espacenet |
1 to 10 of 61
See all 61 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants916
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KARS1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| R01NS124547 | The mammalian multi-tRNA synthetase complex | 4 | 2025 |
| R37AI050234 | Defining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug Resistance | 4 | 2025 |
| P01CA100730 | Retrovirus Models of Cancer | 3 | 2025 |
| P30AI027767 | UAB Center for AIDS Research (CFAR) | 3 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 3 | 2025 |
| ZIAHG200359 | Genomic Ascertainment - Molecular and Genetic Aspects | 3 | 2025 |
| ZIBHG000196 | Inter- and Intra-Species Comparative Sequencing | 3 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 2 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 916Source NIH's project files
See all 916 nih grantsPapers1,650
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Aminoacyl-tRNA synthetases in tumor immunity: canonical translation, source-resolved immune circuits and therapeutic opportunities. | Front Immunol | 2026 | 42769515 | PubTator, text mining | PubMed |
| Neuropathologic Features of Adult-Onset Progressive Leukodystrophy Due to KARS Pathogenic Variants: A Case Report. | Neurol Genet | 2026 | 42621967 | PubTator, text mining | PubMed |
| In silico and in ovo model evaluation of thymol as an anticryptosporidial agent. | Vet Parasitol | 2026 | 42600387 | PubTator, text mining | PubMed |
| Electrochemiluminescence immunoassay for quantifying ZMA001 in human serum: method development, validation, and clinical pharmacokinetic application. | Bioanalysis | 2026 | 42584159 | PubTator, text mining | PubMed |
| Structural and Energetic Determinants of Monobody Recognition of Oncogenic KRAS Variants. | bioRxiv | 2026 | 42465394 | PubTator, text mining | PubMed |
| Utility of mimicking B cell epitopes between Mycobacterium leprae and host as prognostic biomarkers in type 1 reaction in leprosy. | Sci Rep | 2026 | 42265262 | PubTator, text mining | PubMed |
| Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites. | J Med Chem | 2026 | 42227818 | PubTator, text mining | PubMed |
| [Role of Receptor Tyrosine Kinase AXL in Cancer Targeted Therapy Drug Resistance]. | Zhongguo Fei Ai Za Zhi | 2026 | 41916916 | PubTator, text mining | PubMed |
| Expanding the Genetic Code with Lysine Aminoacylation. | J Am Chem Soc | 2026 | 41834353 | PubTator, text mining | PubMed |
| Translational regulation by oxidative desulfuration of tRNA modifications. | Nat Commun | 2026 | 41807381 | PubTator, text mining | PubMed |
1 to 10 of 1,650
See all 1,650 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3735
GET https://conductscience.org/api/genes/v1/3735/patents?page=2