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Gene · 3753

KCNE1: potassium voltage-gated channel subfamily E regulatory subunit 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNE1: potassium voltage-gated channel subfamily E regulatory subunit 1. Genes, record 3753. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3753

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Gene

Symbol
KCNE1
HGNC
Name
potassium voltage-gated channel subfamily E regulatory subunit 1
HGNC
NCBI Gene ID
3753
NCBI Gene
HGNC ID
HGNC:6240
HGNC
Ensembl
ENSG00000180509
NCBI Gene
Aliases
ISK, IsK, JLNS, JLNS2, LQT2/5, LQT5, MinK, minK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P15382Potassium voltage-gated channel subfamily E member 11295Ensembl, GeneID, HGNC

Source UniProt

Patents55

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458713P15382Espacenet
JP 2026004568 A2026-01-1458714P15382Espacenet
JP 2026004568 A2026-01-1458715P15382Espacenet
JP 2026004568 A2026-01-1458716P15382Espacenet
JP 2026004568 A2026-01-1458717P15382Espacenet
JP 2026004568 A2026-01-1458718P15382Espacenet
EP 4640849 A22025-10-29904P15382Espacenet
EP 4641201 A22025-10-296026P15382Espacenet
JP 2025529142 A2025-09-042202P15382Espacenet
US 12371689 B22025-07-292202P15382Espacenet

1 to 10 of 55

See all 55 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,447

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNE1 papersNewest fiscal year
R01HL122010Decrypting Variants of Uncertain Significance in Long-QT Syndrome222025
R35GM126935EPR Spectroscopic Studies of Membrane Proteins112025
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL92025
P30DK063491Diabetes Research Center (DRC)72025
P30CA068485Cancer Center Support Grant62025
R01HL059949Structural Determinants of PIP2 Regulation62025
R35GM130377Ion Channel Transporter Interactions62025
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation52025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal42025
T32GM007569Clinical Pharmacology Training Program42025

1 to 10 of 1,447Source NIH's project files

See all 1,447 nih grants

Papers2,266

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Functional heterogeneity of arrhythmogenic KCNQ1 S1 mutants reveals dependence on the number of KCNE1 subunits in the IKs channel complex.Heart Rhythm202642790796PubTator, text miningPubMed
Synthetic cannabinoid receptor agonists inhibit the cardiac voltage-gated potassium channel hERG.Acta Pharmacol Sin202642477142PubTator, text miningPubMed
Multimodality Risk Stratification in Athletes With Long QT Syndrome.JACC Case Rep202642460964PubTator, text miningPubMed
Aberrant TMPRSS6-Protease Regulation of Disease Mutant HCN4-KCNE1 Channel Complex Depends on the KCNE1-G38S Polymorphism.Arch Pharm (Weinheim)202642424558PubTator, text miningPubMed
Jervell and Lange-Nielsen Syndrome Related Clinical Genetics and Experimental Models.Pediatr Discov202642389506PubTator, text miningPubMed
C-terminal long-QT type 1 R562S-Kv7.1 variant, the first variant in helix C impairing β-adrenergic response of the slow delayed rectifier K+ channel.Europace202642314170PubTator, text miningPubMed
Optimization of novel compounds using computer-aided drug design for treatment of cardiac arrhythmia.Br J Pharmacol202642298290PubTator, text miningPubMed
PIP2 activation of the cardiac IKs potassium channel.Nat Commun202642270663PubTator, text miningPubMed
Long QT Syndrome Type 5 With Coexisting KCNE1 and RYR2 Variants: A Diagnostic Ambiguity.Clin Case Rep202642256913PubTator, text miningPubMed
Long QT syndrome and hypoglycemia in a postbariatric surgery patient with a likely pathogenic variant in KCNE1.JCEM Case Rep202642256639PubTator, text miningPubMed

1 to 10 of 2,266

See all 2,266 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3753

GET https://conductscience.org/api/genes/v1/3753/patents?page=2