Gene · 3753
KCNE1: potassium voltage-gated channel subfamily E regulatory subunit 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KCNE1: potassium voltage-gated channel subfamily E regulatory subunit 1. Genes, record 3753. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3753
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P15382 | Potassium voltage-gated channel subfamily E member 1 | 129 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents55
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58713 | P15382 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58714 | P15382 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58715 | P15382 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58716 | P15382 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58717 | P15382 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58718 | P15382 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 904 | P15382 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6026 | P15382 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2202 | P15382 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2202 | P15382 | Espacenet |
1 to 10 of 55
See all 55 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,447
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KCNE1 papers | Newest fiscal year |
|---|---|---|---|
| R01HL122010 | Decrypting Variants of Uncertain Significance in Long-QT Syndrome | 22 | 2025 |
| R35GM126935 | EPR Spectroscopic Studies of Membrane Proteins | 11 | 2025 |
| R01HL092577 | IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL | 9 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 7 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 6 | 2025 |
| R01HL059949 | Structural Determinants of PIP2 Regulation | 6 | 2025 |
| R35GM130377 | Ion Channel Transporter Interactions | 6 | 2025 |
| R01HL131517 | Sex-specific arrhythmogenic mechanisms of atrial fibrillation | 5 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 4 | 2025 |
| T32GM007569 | Clinical Pharmacology Training Program | 4 | 2025 |
1 to 10 of 1,447Source NIH's project files
See all 1,447 nih grantsPapers2,266
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Functional heterogeneity of arrhythmogenic KCNQ1 S1 mutants reveals dependence on the number of KCNE1 subunits in the IKs channel complex. | Heart Rhythm | 2026 | 42790796 | PubTator, text mining | PubMed |
| Synthetic cannabinoid receptor agonists inhibit the cardiac voltage-gated potassium channel hERG. | Acta Pharmacol Sin | 2026 | 42477142 | PubTator, text mining | PubMed |
| Multimodality Risk Stratification in Athletes With Long QT Syndrome. | JACC Case Rep | 2026 | 42460964 | PubTator, text mining | PubMed |
| Aberrant TMPRSS6-Protease Regulation of Disease Mutant HCN4-KCNE1 Channel Complex Depends on the KCNE1-G38S Polymorphism. | Arch Pharm (Weinheim) | 2026 | 42424558 | PubTator, text mining | PubMed |
| Jervell and Lange-Nielsen Syndrome Related Clinical Genetics and Experimental Models. | Pediatr Discov | 2026 | 42389506 | PubTator, text mining | PubMed |
| C-terminal long-QT type 1 R562S-Kv7.1 variant, the first variant in helix C impairing β-adrenergic response of the slow delayed rectifier K+ channel. | Europace | 2026 | 42314170 | PubTator, text mining | PubMed |
| Optimization of novel compounds using computer-aided drug design for treatment of cardiac arrhythmia. | Br J Pharmacol | 2026 | 42298290 | PubTator, text mining | PubMed |
| PIP2 activation of the cardiac IKs potassium channel. | Nat Commun | 2026 | 42270663 | PubTator, text mining | PubMed |
| Long QT Syndrome Type 5 With Coexisting KCNE1 and RYR2 Variants: A Diagnostic Ambiguity. | Clin Case Rep | 2026 | 42256913 | PubTator, text mining | PubMed |
| Long QT syndrome and hypoglycemia in a postbariatric surgery patient with a likely pathogenic variant in KCNE1. | JCEM Case Rep | 2026 | 42256639 | PubTator, text mining | PubMed |
1 to 10 of 2,266
See all 2,266 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3753
GET https://conductscience.org/api/genes/v1/3753/patents?page=2