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KCNH2: potassium voltage-gated channel subfamily H member 2

1 protein, 90 patents, 18 drugs, 175 trials, 4,147 NIH grants and 11,376 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolKCNH2HGNC
Namepotassium voltage-gated channel subfamily H member 2HGNC
NCBI Gene ID3757NCBI Gene
HGNC IDHGNC:6251HGNC
EnsemblENSG00000055118NCBI Gene
AliasesERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1, LQT2, SQT1, erg1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q12809Voltage-gated inwardly rectifying potassium channel KCNH21,15924Ensembl, GeneID, HGNCUniProt

Patents 90

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458813Q12809Espacenet
EP 4640849 A22025-10-29243Q12809Espacenet
EP 4641201 A22025-10-291592Q12809Espacenet
JP 2025147176 A2025-10-0614940Q12809Espacenet
JP 2025529142 A2025-09-042212Q12809Espacenet
US 12371689 B22025-07-292212Q12809Espacenet
JP 2025519096 A2025-06-24243Q12809Espacenet
JP 2025517969 A2025-06-121592Q12809Espacenet
JP 2025028160 A2025-02-2814940Q12809Espacenet
KR 1020250010750 A2025-01-2114940Q12809Espacenet

Drugs 18

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIODARONECHEMBL633HERG blockerBLOCKERChEMBL
AMIODARONE HYDROCHLORIDECHEMBL1083993HERG blockerBLOCKERChEMBL
AZD1305CHEMBL3545169HERG blockerBLOCKERChEMBL
AZD7009CHEMBL3545040HERG blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
DOFETILIDECHEMBL473HERG blockerBLOCKERChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL

Trials 175

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06680869AMIODARONE HYDROCHLORIDEPHASE3ClinicalTrials.gov
NCT06669299SOTALOLClinicalTrials.gov
NCT06669299AMIODARONEClinicalTrials.gov
NCT06657404AMIODARONEClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov

NIH grants 4147

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
T32HL007936Training Program in Translational Cardiovascular Science162,025NIH's project files
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL152,025NIH's project files
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling142,025NIH's project files
R01HL076485Engineering Vascularized Cardiac Muscle122,025NIH's project files
T32GM007569Clinical Pharmacology Training Program122,025NIH's project files
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology112,025NIH's project files
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation112,025NIH's project files
R01HL131403Translational Control of Cardiac Excitability102,025NIH's project files
R35HL144980Toward a Mechanism-Based Approach to Treating Cardiac Arrhythmia102,025NIH's project files
ZIATR000040Toxicology in the 21st Century Program (Tox21) - Computational Toxicology102,025NIH's project files

Papers 11376

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826517PubTator, text miningPubMed
42825936PubTator, text miningPubMed
42798882PubTator, text miningPubMed
42798645PubTator, text miningPubMed
42794641PubTator, text miningPubMed
42792731PubTator, text miningPubMed
42790797PubTator, text miningPubMed
42775453PubTator, text miningPubMed
42771720PubTator, text miningPubMed
42761608PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license