Gene · 3758
KCNJ1: potassium inwardly rectifying channel subfamily J member 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KCNJ1: potassium inwardly rectifying channel subfamily J member 1. Genes, record 3758. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3758
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P48048 | ATP-sensitive inward rectifier potassium channel 1 | 391 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents30
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58638 | P48048 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 11341 | P48048 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2220 | P48048 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2220 | P48048 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 11341 | P48048 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 65608 | P48048 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 69 | P48048 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 168579 | P48048 | Espacenet |
| EP 3876956 A1 | 2021-09-15 | 259 | P48048 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 5750 | P48048 | Espacenet |
1 to 10 of 30
See all 30 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants986
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KCNJ1 papers | Newest fiscal year |
|---|---|---|---|
| R01DK054231 | Molecular of ROMK Channel Function | 13 | 2025 |
| R01DK051496 | WNK Kinase Regulation of Thiazide-sensitive NaCl Transport | 11 | 2025 |
| R01HL059949 | Structural Determinants of PIP2 Regulation | 5 | 2025 |
| R01DK093501 | WNK-SPAK signaling in the Distal Nephron | 4 | 2025 |
| R01DK098141 | Regulation of renal ion transport by the CUL3-WNK-SPAK pathway | 4 | 2025 |
| R01DK129285 | Role of piezo channels in intercalated cells | 4 | 2025 |
| R35GM131732 | ER and post-ER quality control of integral membrane proteins | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 3 | 2025 |
| R01DK076077 | Adaptive and maladaptive repair after kidney injury | 3 | 2025 |
1 to 10 of 986Source NIH's project files
See all 986 nih grantsPapers1,472
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Profiling miRNAs Involved in Human Oligodendrocyte Precursor Cell Differentiation and Maturation. | Cells | 2026 | 42587753 | PubTator, text mining | PubMed |
| Unlocking potassium secretion: the roles of aldosterone, ROMK, and WNK kinases in kidney potassium handling. | Kidney Res Clin Pract | 2026 | 42548167 | PubTator, text mining | PubMed |
| Integrative Multi-Transcriptomic Uncovers Actionable Signatures and Drug Repurposing Candidates for ccRCC-Hypertension Comorbidity. | Cancers (Basel) | 2026 | 42512315 | PubTator, text mining | PubMed |
| The teleologic basis of kidney potassium handling: a conceptual review. | Kidney Int | 2026 | 42508608 | PubTator, text mining | PubMed |
| Prenatal diagnosis of antenatal Bartter syndrome: Another four case reports. | Taiwan J Obstet Gynecol | 2026 | 42362273 | PubTator, text mining | PubMed |
| Molecular Genetics of Bartter Syndrome: Bridging Genotype-Phenotype Correlations and Precision Therapeutics. | Curr Issues Mol Biol | 2026 | 42042082 | PubTator, text mining | PubMed |
| Hypomagnesemia: A Clinical and Nutritional Update. | Curr Nutr Rep | 2026 | 41872423 | PubTator, text mining | PubMed |
| Piezo1 dictates K+ homeostasis through coordinated regulation of the ubiquitin ligase Kelch-like 3 in RBCs and the kidney. | Proc Natl Acad Sci U S A | 2026 | 41533447 | PubTator, text mining | PubMed |
| Diagnostic Value of Exome Sequencing in Isolated Polyhydramnios. | Prenat Diagn | 2026 | 41330877 | PubTator, text mining | PubMed |
| Profiling miRNAs involved in Human Oligodendrocyte Precursor Cell Differentiation and Maturation. | bioRxiv | 2025 | 41497631 | PubTator, text mining | PubMed |
1 to 10 of 1,472
See all 1,472 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3758
GET https://conductscience.org/api/genes/v1/3758/patents?page=2