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Gene · 3758

KCNJ1: potassium inwardly rectifying channel subfamily J member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNJ1: potassium inwardly rectifying channel subfamily J member 1. Genes, record 3758. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3758

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Gene

Symbol
KCNJ1
HGNC
Name
potassium inwardly rectifying channel subfamily J member 1
HGNC
NCBI Gene ID
3758
NCBI Gene
HGNC ID
HGNC:6255
HGNC
Ensembl
ENSG00000151704
NCBI Gene
Aliases
KIR1.1, Kir1.1, ROMK, ROMK1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48048ATP-sensitive inward rectifier potassium channel 13910Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458638P48048Espacenet
EP 4641201 A22025-10-2911341P48048Espacenet
JP 2025529142 A2025-09-042220P48048Espacenet
US 12371689 B22025-07-292220P48048Espacenet
JP 2025517969 A2025-06-1211341P48048Espacenet
US 11446398 B22022-09-2065608P48048Espacenet
US 11400116 B22022-08-0269P48048Espacenet
JP 2022524081 A2022-04-27168579P48048Espacenet
EP 3876956 A12021-09-15259P48048Espacenet
US 11078247 B22021-08-035750P48048Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants986

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNJ1 papersNewest fiscal year
R01DK054231Molecular of ROMK Channel Function132025
R01DK051496WNK Kinase Regulation of Thiazide-sensitive NaCl Transport112025
R01HL059949Structural Determinants of PIP2 Regulation52025
R01DK093501WNK-SPAK signaling in the Distal Nephron42025
R01DK098141Regulation of renal ion transport by the CUL3-WNK-SPAK pathway42025
R01DK129285Role of piezo channels in intercalated cells42025
R35GM131732ER and post-ER quality control of integral membrane proteins42025
P30CA068485Cancer Center Support Grant32025
P30DK058404Molecular and Cellular Basis for Digestive Diseases32025
R01DK076077Adaptive and maladaptive repair after kidney injury32025

1 to 10 of 986Source NIH's project files

See all 986 nih grants

Papers1,472

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Profiling miRNAs Involved in Human Oligodendrocyte Precursor Cell Differentiation and Maturation.Cells202642587753PubTator, text miningPubMed
Unlocking potassium secretion: the roles of aldosterone, ROMK, and WNK kinases in kidney potassium handling.Kidney Res Clin Pract202642548167PubTator, text miningPubMed
Integrative Multi-Transcriptomic Uncovers Actionable Signatures and Drug Repurposing Candidates for ccRCC-Hypertension Comorbidity.Cancers (Basel)202642512315PubTator, text miningPubMed
The teleologic basis of kidney potassium handling: a conceptual review.Kidney Int202642508608PubTator, text miningPubMed
Prenatal diagnosis of antenatal Bartter syndrome: Another four case reports.Taiwan J Obstet Gynecol202642362273PubTator, text miningPubMed
Molecular Genetics of Bartter Syndrome: Bridging Genotype-Phenotype Correlations and Precision Therapeutics.Curr Issues Mol Biol202642042082PubTator, text miningPubMed
Hypomagnesemia: A Clinical and Nutritional Update.Curr Nutr Rep202641872423PubTator, text miningPubMed
Piezo1 dictates K+ homeostasis through coordinated regulation of the ubiquitin ligase Kelch-like 3 in RBCs and the kidney.Proc Natl Acad Sci U S A202641533447PubTator, text miningPubMed
Diagnostic Value of Exome Sequencing in Isolated Polyhydramnios.Prenat Diagn202641330877PubTator, text miningPubMed
Profiling miRNAs involved in Human Oligodendrocyte Precursor Cell Differentiation and Maturation.bioRxiv202541497631PubTator, text miningPubMed

1 to 10 of 1,472

See all 1,472 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3758

GET https://conductscience.org/api/genes/v1/3758/patents?page=2