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Gene · 3762

KCNJ5: potassium inwardly rectifying channel subfamily J member 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNJ5: potassium inwardly rectifying channel subfamily J member 5. Genes, record 3762. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3762

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Gene

Symbol
KCNJ5
HGNC
Name
potassium inwardly rectifying channel subfamily J member 5
HGNC
NCBI Gene ID
3762
NCBI Gene
HGNC ID
HGNC:6266
HGNC
Ensembl
ENSG00000120457
NCBI Gene
Aliases
CIR, GIRK4, KATP1, KIR3.4, Kir3.4, LQT13
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48544G protein-activated inward rectifier potassium channel 44190Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458673P48544Espacenet
JP 2026004568 A2026-01-1458674P48544Espacenet
JP 2026004568 A2026-01-1458675P48544Espacenet
EP 4641201 A22025-10-296242P48544Espacenet
JP 2025529142 A2025-09-042231P48544Espacenet
KR 1020250115381 A2025-07-3038P48544Espacenet
US 12371689 B22025-07-292231P48544Espacenet
JP 2025517969 A2025-06-126242P48544Espacenet
EP 4357359 A12024-04-241P48544Espacenet
US 11484543 B22022-11-017P48544Espacenet

1 to 10 of 36

See all 36 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
VERNAKALANTCHEMBL2111112Kir3.1/Kir3.4 blockerBLOCKERChEMBL
VERNAKALANT HYDROCHLORIDECHEMBL2107383Kir3.1/Kir3.4 blockerBLOCKERChEMBL

Trials10

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04748991VERNAKALANTPHASE3ClinicalTrials.gov
NCT01174160VERNAKALANT HYDROCHLORIDEPHASE32015-12-15ClinicalTrials.gov
NCT00989001VERNAKALANT HYDROCHLORIDEPHASE3ClinicalTrials.gov
NCT00668759VERNAKALANTPHASE3ClinicalTrials.gov
NCT00476112VERNAKALANTPHASE2/PHASE3ClinicalTrials.gov
NCT00468767VERNAKALANTPHASE3ClinicalTrials.gov
NCT00281554VERNAKALANTPHASE3ClinicalTrials.gov
NCT00267930VERNAKALANTPHASE2ClinicalTrials.gov
NCT00125320VERNAKALANT HYDROCHLORIDEPHASE3ClinicalTrials.gov
NCT00115791VERNAKALANT HYDROCHLORIDEPHASE3ClinicalTrials.gov

NIH grants705

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNJ5 papersNewest fiscal year
R01HL059949Structural Determinants of PIP2 Regulation242025
U54GM115428Mississippi Center for Clinical and Translational Research232025
R01DK043140Mechanisms Leading to Adrenal Zonation132025
R01AA018734Structural Analysis of Alcohol-dependent Activation of GIRKs72025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202862025
R01HL135109Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation62025
R01MH084894Function of GPCR heteromeric complexes in brain52025
UL1TR001863Yale Clinical and Translational Science Award52025
P30CA068485Cancer Center Support Grant42025
R01DK115392Unrecognized Primary Aldosteronism as a Pathogenic Mechanism for Chronic Kidney Disease in Diabetes42025

1 to 10 of 705Source NIH's project files

See all 705 nih grants

Papers1,500

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Antibiotics and the Endocrine System: Mechanisms, Adverse Effects, and Clinical Implications.Antibiotics (Basel)202642792007PubTator, text miningPubMed
Identification of a novel small-molecule compound that suppresses depolarization-induced CYP11B2 expression and aldosterone production in KCNJ5 mutant adrenocortical cells.Biochem Biophys Res Commun202642777615PubTator, text miningPubMed
A green-fluorogenic, cysteine-reactive dye enables thermal shift-based high-throughput screening with membrane proteins.J Biol Chem202642754164PubTator, text miningPubMed
Tumor-specific KCNJ5 mutation in an aldosterone-producing adenoma not detected in adrenal venous plasma cell-free DNA.JCEM Case Rep202642666717PubTator, text miningPubMed
Macrolide-induced aldosterone suppression as a functional marker of KCNJ5-mutated aldosterone-producing adenoma: a proof-of-concept clinical and experimental study (MAPA study).Eur J Endocrinol202642663598PubTator, text miningPubMed
From bench to bedside: primary aldosteronism revisited.Endocr Connect202642644335PubTator, text miningPubMed
Selective Cell Death of Adrenocortical Cells by Pharmacological Activation of Mutant KCNJ5.Hypertension202642605674PubTator, text miningPubMed
Coexistence of primary aldosteronism and micro-pheochromocytoma: a case report with pathological analysis and literature review.Front Med (Lausanne)202642559225PubTator, text miningPubMed
[Primary aldosteronism as an independent factor of kidney damage. Potential therapeutic strategies and research prospects].Probl Endokrinol (Mosk)202642545319PubTator, text miningPubMed
KCNJ5-Dependent 68Ga-Pentixafor PET/CT in Primary Aldosteronism Surgery.J Clin Endocrinol Metab202642531454PubTator, text miningPubMed

1 to 10 of 1,500

See all 1,500 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3762

GET https://conductscience.org/api/genes/v1/3762/patents?page=2