Gene · 3762
KCNJ5: potassium inwardly rectifying channel subfamily J member 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KCNJ5: potassium inwardly rectifying channel subfamily J member 5. Genes, record 3762. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3762
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P48544 | G protein-activated inward rectifier potassium channel 4 | 419 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents36
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58673 | P48544 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58674 | P48544 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58675 | P48544 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6242 | P48544 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2231 | P48544 | Espacenet |
| KR 1020250115381 A | 2025-07-30 | 38 | P48544 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2231 | P48544 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6242 | P48544 | Espacenet |
| EP 4357359 A1 | 2024-04-24 | 1 | P48544 | Espacenet |
| US 11484543 B2 | 2022-11-01 | 7 | P48544 | Espacenet |
1 to 10 of 36
See all 36 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials10
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04748991 | VERNAKALANT | PHASE3 | ClinicalTrials.gov | |
| NCT01174160 | VERNAKALANT HYDROCHLORIDE | PHASE3 | 2015-12-15 | ClinicalTrials.gov |
| NCT00989001 | VERNAKALANT HYDROCHLORIDE | PHASE3 | ClinicalTrials.gov | |
| NCT00668759 | VERNAKALANT | PHASE3 | ClinicalTrials.gov | |
| NCT00476112 | VERNAKALANT | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT00468767 | VERNAKALANT | PHASE3 | ClinicalTrials.gov | |
| NCT00281554 | VERNAKALANT | PHASE3 | ClinicalTrials.gov | |
| NCT00267930 | VERNAKALANT | PHASE2 | ClinicalTrials.gov | |
| NCT00125320 | VERNAKALANT HYDROCHLORIDE | PHASE3 | ClinicalTrials.gov | |
| NCT00115791 | VERNAKALANT HYDROCHLORIDE | PHASE3 | ClinicalTrials.gov |
NIH grants705
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KCNJ5 papers | Newest fiscal year |
|---|---|---|---|
| R01HL059949 | Structural Determinants of PIP2 Regulation | 24 | 2025 |
| U54GM115428 | Mississippi Center for Clinical and Translational Research | 23 | 2025 |
| R01DK043140 | Mechanisms Leading to Adrenal Zonation | 13 | 2025 |
| R01AA018734 | Structural Analysis of Alcohol-dependent Activation of GIRKs | 7 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 6 | 2025 |
| R01HL135109 | Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation | 6 | 2025 |
| R01MH084894 | Function of GPCR heteromeric complexes in brain | 5 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| R01DK115392 | Unrecognized Primary Aldosteronism as a Pathogenic Mechanism for Chronic Kidney Disease in Diabetes | 4 | 2025 |
1 to 10 of 705Source NIH's project files
See all 705 nih grantsPapers1,500
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Antibiotics and the Endocrine System: Mechanisms, Adverse Effects, and Clinical Implications. | Antibiotics (Basel) | 2026 | 42792007 | PubTator, text mining | PubMed |
| Identification of a novel small-molecule compound that suppresses depolarization-induced CYP11B2 expression and aldosterone production in KCNJ5 mutant adrenocortical cells. | Biochem Biophys Res Commun | 2026 | 42777615 | PubTator, text mining | PubMed |
| A green-fluorogenic, cysteine-reactive dye enables thermal shift-based high-throughput screening with membrane proteins. | J Biol Chem | 2026 | 42754164 | PubTator, text mining | PubMed |
| Tumor-specific KCNJ5 mutation in an aldosterone-producing adenoma not detected in adrenal venous plasma cell-free DNA. | JCEM Case Rep | 2026 | 42666717 | PubTator, text mining | PubMed |
| Macrolide-induced aldosterone suppression as a functional marker of KCNJ5-mutated aldosterone-producing adenoma: a proof-of-concept clinical and experimental study (MAPA study). | Eur J Endocrinol | 2026 | 42663598 | PubTator, text mining | PubMed |
| From bench to bedside: primary aldosteronism revisited. | Endocr Connect | 2026 | 42644335 | PubTator, text mining | PubMed |
| Selective Cell Death of Adrenocortical Cells by Pharmacological Activation of Mutant KCNJ5. | Hypertension | 2026 | 42605674 | PubTator, text mining | PubMed |
| Coexistence of primary aldosteronism and micro-pheochromocytoma: a case report with pathological analysis and literature review. | Front Med (Lausanne) | 2026 | 42559225 | PubTator, text mining | PubMed |
| [Primary aldosteronism as an independent factor of kidney damage. Potential therapeutic strategies and research prospects]. | Probl Endokrinol (Mosk) | 2026 | 42545319 | PubTator, text mining | PubMed |
| KCNJ5-Dependent 68Ga-Pentixafor PET/CT in Primary Aldosteronism Surgery. | J Clin Endocrinol Metab | 2026 | 42531454 | PubTator, text mining | PubMed |
1 to 10 of 1,500
See all 1,500 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3762
GET https://conductscience.org/api/genes/v1/3762/patents?page=2