Gene · 3763
KCNJ6: potassium inwardly rectifying channel subfamily J member 6
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KCNJ6: potassium inwardly rectifying channel subfamily J member 6. Genes, record 3763. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3763
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P48051 | G protein-activated inward rectifier potassium channel 2 | 423 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents30
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026222504 A1 | 2026-10-22 | 6 | P48051 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58676 | P48051 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58677 | P48051 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2232 | P48051 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2232 | P48051 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30355 | P48051 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 30355 | P48051 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 30355 | P48051 | Espacenet |
| EP 4163296 A1 | 2023-04-12 | 2 | P48051 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 65666 | P48051 | Espacenet |
1 to 10 of 30
See all 30 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,162
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KCNJ6 papers | Newest fiscal year |
|---|---|---|---|
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 15 | 2025 |
| R01HL059949 | Structural Determinants of PIP2 Regulation | 14 | 2025 |
| R01AA018734 | Structural Analysis of Alcohol-dependent Activation of GIRKs | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| R01DA036596 | Regulation of Neuronal GPCR Signaling | 4 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| P30DK020593 | Vanderbilt Diabetes Research Center | 3 | 2025 |
| R01AI165580 | Elucidating the Structural Mechanisms of NAIP Receptors in Bacterial Detection and Inflammasome Activation | 3 | 2025 |
| R01DK105448 | Genetic and Metabolic Basis of Familial Lipodystrophies | 3 | 2025 |
1 to 10 of 1,162Source NIH's project files
See all 1,162 nih grantsPapers1,352
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The Pharmacogenomics of Opioid Response in Cancer Pain: From Receptor Polymorphisms to Tumour-Mediated Interference-A Narrative-Critical Review. | Int J Mol Sci | 2026 | 42589662 | PubTator, text mining | PubMed |
| Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease. | Adv Sci (Weinh) | 2026 | 42405498 | PubTator, text mining | PubMed |
| Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor culture. | Mol Psychiatry | 2026 | 42310192 | PubTator, text mining | PubMed |
| Structure-based identification of GIRK2-PIP2 modulators: Integrative docking, MM-GBSA, ADMET, and molecular dynamics study. | J Mol Graph Model | 2026 | 42068608 | PubTator, text mining | PubMed |
| Dysregulation of mRNAs and hub genes in Parkinson's disease within post mortem substantia Nigra: using three methods differential expression genes analysis. | Neurosci Lett | 2026 | 41980674 | PubTator, text mining | PubMed |
| Mitotic error correction and the spindle assembly checkpoint: a tension-filled relationship. | Cell Cycle | 2026 | 41930946 | PubTator, text mining | PubMed |
| Microtubules guide Aurora B substrate geometries for accurate chromosome segregation. | Sci Adv | 2026 | 41880487 | PubTator, text mining | PubMed |
| PKC isoform-specific targeting of the phosphorylation site Serine191 in the GIRK4 subunit induces receptor-dependent modulation of GIRK channel activity. | Pflugers Arch | 2026 | 41851344 | PubTator, text mining | PubMed |
| Subcellular calcium dynamics and organelle perturbations in resistosome-mediated cell death. | Proc Natl Acad Sci U S A | 2026 | 41849389 | PubTator, text mining | PubMed |
| α-Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons. | J Physiol | 2026 | 41837580 | PubTator, text mining | PubMed |
1 to 10 of 1,352
See all 1,352 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3763
GET https://conductscience.org/api/genes/v1/3763/patents?page=2