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Gene · 3763

KCNJ6: potassium inwardly rectifying channel subfamily J member 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNJ6: potassium inwardly rectifying channel subfamily J member 6. Genes, record 3763. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3763

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Gene

Symbol
KCNJ6
HGNC
Name
potassium inwardly rectifying channel subfamily J member 6
HGNC
NCBI Gene ID
3763
NCBI Gene
HGNC ID
HGNC:6267
HGNC
Ensembl
ENSG00000157542
NCBI Gene
Aliases
BIR1, GIRK-2, GIRK2, KATP-2, KATP2, KCNJ7, KIR3.2, KPLBS, Kir3.2, hiGIRK2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48051G protein-activated inward rectifier potassium channel 24230Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026222504 A12026-10-226P48051Espacenet
JP 2026004568 A2026-01-1458676P48051Espacenet
JP 2026004568 A2026-01-1458677P48051Espacenet
JP 2025529142 A2025-09-042232P48051Espacenet
US 12371689 B22025-07-292232P48051Espacenet
JP 2025032204 A2025-03-1130355P48051Espacenet
EP 4461818 A22024-11-1330355P48051Espacenet
JP 2023058610 A2023-04-2530355P48051Espacenet
EP 4163296 A12023-04-122P48051Espacenet
US 11446398 B22022-09-2065666P48051Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,162

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNJ6 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).152025
R01HL059949Structural Determinants of PIP2 Regulation142025
R01AA018734Structural Analysis of Alcohol-dependent Activation of GIRKs132025
P30CA008748Cancer Center Support Grant72025
R01DA036596Regulation of Neuronal GPCR Signaling42025
P30CA014195Cancer Center Support Grant (CCSG)32025
P30CA068485Cancer Center Support Grant32025
P30DK020593Vanderbilt Diabetes Research Center32025
R01AI165580Elucidating the Structural Mechanisms of NAIP Receptors in Bacterial Detection and Inflammasome Activation32025
R01DK105448Genetic and Metabolic Basis of Familial Lipodystrophies32025

1 to 10 of 1,162Source NIH's project files

See all 1,162 nih grants

Papers1,352

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Pharmacogenomics of Opioid Response in Cancer Pain: From Receptor Polymorphisms to Tumour-Mediated Interference-A Narrative-Critical Review.Int J Mol Sci202642589662PubTator, text miningPubMed
Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease.Adv Sci (Weinh)202642405498PubTator, text miningPubMed
Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor culture.Mol Psychiatry202642310192PubTator, text miningPubMed
Structure-based identification of GIRK2-PIP2 modulators: Integrative docking, MM-GBSA, ADMET, and molecular dynamics study.J Mol Graph Model202642068608PubTator, text miningPubMed
Dysregulation of mRNAs and hub genes in Parkinson's disease within post mortem substantia Nigra: using three methods differential expression genes analysis.Neurosci Lett202641980674PubTator, text miningPubMed
Mitotic error correction and the spindle assembly checkpoint: a tension-filled relationship.Cell Cycle202641930946PubTator, text miningPubMed
Microtubules guide Aurora B substrate geometries for accurate chromosome segregation.Sci Adv202641880487PubTator, text miningPubMed
PKC isoform-specific targeting of the phosphorylation site Serine191 in the GIRK4 subunit induces receptor-dependent modulation of GIRK channel activity.Pflugers Arch202641851344PubTator, text miningPubMed
Subcellular calcium dynamics and organelle perturbations in resistosome-mediated cell death.Proc Natl Acad Sci U S A202641849389PubTator, text miningPubMed
α-Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons.J Physiol202641837580PubTator, text miningPubMed

1 to 10 of 1,352

See all 1,352 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3763

GET https://conductscience.org/api/genes/v1/3763/patents?page=2