Gene · 3764
KCNJ8: potassium inwardly rectifying channel subfamily J member 8
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KCNJ8: potassium inwardly rectifying channel subfamily J member 8. Genes, record 3764. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3764
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q15842 | ATP-sensitive inward rectifier potassium channel 8 | 424 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents25
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58678 | Q15842 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58680 | Q15842 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 717 | Q15842 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2233 | Q15842 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2233 | Q15842 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 717 | Q15842 | Espacenet |
| KR 1020230136786 A | 2023-09-27 | 25 | Q15842 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 65667 | Q15842 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3189 | Q15842 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 168638 | Q15842 | Espacenet |
1 to 10 of 25
See all 25 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials15
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07403604 | DIAZOXIDE | PHASE1 | ClinicalTrials.gov | |
| NCT06606327 | DIAZOXIDE | PHASE1 | ClinicalTrials.gov | |
| NCT05729282 | DIAZOXIDE | PHASE1 | ClinicalTrials.gov | |
| NCT03566511 | DIAZOXIDE | PHASE2 | 2025-05-31 | ClinicalTrials.gov |
| NCT03540758 | DIAZOXIDE | PHASE2 | ClinicalTrials.gov | |
| NCT02049385 | DIAZOXIDE | PHASE1/PHASE2 | 2017-10-13 | ClinicalTrials.gov |
| NCT02034071 | DIAZOXIDE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT01488136 | DIAZOXIDE | PHASE4 | ClinicalTrials.gov | |
| NCT00994149 | DIAZOXIDE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT00892073 | DIAZOXIDE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 15
See all 15 trialsNIH grants719
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KCNJ8 papers | Newest fiscal year |
|---|---|---|---|
| R35HL171542 | Cardiovascular potassium channels: From molecular basis to disease therapeutics | 4 | 2025 |
| P30DK020579 | Diabetes Research Center | 3 | 2025 |
| R01GM145784 | Correlating structure and function in KATP channel isoforms | 3 | 2025 |
| R01HL071158 | Acid, Succinate and Glyoxal Metabolism in Ischemia | 3 | 2025 |
| R01HL092577 | IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL | 3 | 2025 |
| P01AG029531 | The Aging Pituitary/Gonadal Axis | 2 | 2025 |
| P01AG052350 | Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's Disease | 2 | 2025 |
| P01HL151328 | Triglycerides, Diabetes and Cardiovascular Disease | 2 | 2025 |
| P30AR074992 | RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE | 2 | 2025 |
| P30CA014520 | UW Comprehensive Cancer Center Support | 2 | 2025 |
1 to 10 of 719Source NIH's project files
See all 719 nih grantsPapers1,154
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Emerging pharmacological targets in migraine therapy: CGRP and beyond. | Front Pharmacol | 2026 | 42781272 | PubTator, text mining | PubMed |
| From Array-CGH to Whole-Genome Sequencing: A 29-Year Diagnostic Journey Culminating in the Identification of a De Novo ABCC9 Variant Consistent with Cantú Syndrome. | Diagnostics (Basel) | 2026 | 42510068 | PubTator, text mining | PubMed |
| Cardiac ventricular Kir6.1 ATP-sensitive potassium channels: an overlooked effector of cardioprotection. | Front Physiol | 2026 | 42088949 | PubTator, text mining | PubMed |
| [Exogenous nitric oxide suppresses K ATP channel activity through S-nitrosylation]. | Sheng Wu Yi Xue Gong Cheng Xue Za Zhi | 2026 | 42037343 | PubTator, text mining | PubMed |
| Biophysical Characterization of a Novel KCNJ8 Rare Variant Linked With Inherited and Acquired J Wave Syndrome. | JACC Clin Electrophysiol | 2026 | 41995661 | PubTator, text mining | PubMed |
| MitoQ Triggers Mitochondrial Collapse and Apoptotic Death in Glioblastoma Associated with KATP Channel Expression Changes. | Neurochem Res | 2026 | 41910839 | PubTator, text mining | PubMed |
| Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx. | Theranostics | 2026 | 41799190 | PubTator, text mining | PubMed |
| PINCH proteins orchestrate vascular mural cell homeostasis through integrated signaling and transcriptional networks. | Angiogenesis | 2026 | 41795751 | PubTator, text mining | PubMed |
| Genetic Variants in Potassium Channel Genes and Their Clinical Implications in Kazakhstani Patients with Cardiac Arrhythmias. | J Pers Med | 2026 | 41745353 | PubTator, text mining | PubMed |
| Aging-Induced QT Prolongation as a Potential Contributor to Longevity. | J Cardiovasc Dev Dis | 2026 | 41745334 | PubTator, text mining | PubMed |
1 to 10 of 1,154
See all 1,154 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3764
GET https://conductscience.org/api/genes/v1/3764/patents?page=2