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Gene · 3764

KCNJ8: potassium inwardly rectifying channel subfamily J member 8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNJ8: potassium inwardly rectifying channel subfamily J member 8. Genes, record 3764. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3764

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Gene

Symbol
KCNJ8
HGNC
Name
potassium inwardly rectifying channel subfamily J member 8
HGNC
NCBI Gene ID
3764
NCBI Gene
HGNC ID
HGNC:6269
HGNC
Ensembl
ENSG00000121361
NCBI Gene
Aliases
KIR6.1, Kir6.1, uKATP-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15842ATP-sensitive inward rectifier potassium channel 84240Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458678Q15842Espacenet
JP 2026004568 A2026-01-1458680Q15842Espacenet
EP 4641201 A22025-10-29717Q15842Espacenet
JP 2025529142 A2025-09-042233Q15842Espacenet
US 12371689 B22025-07-292233Q15842Espacenet
JP 2025517969 A2025-06-12717Q15842Espacenet
KR 1020230136786 A2023-09-2725Q15842Espacenet
US 11446398 B22022-09-2065667Q15842Espacenet
US 11400116 B22022-08-023189Q15842Espacenet
JP 2022524081 A2022-04-27168638Q15842Espacenet

1 to 10 of 25

See all 25 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIAZOXIDECHEMBL181Potassium channel, inwardly rectifying, subfamily J, member 8 openerOPENERChEMBL
NAMINIDILCHEMBL2105160Sulfonylurea receptors; K-ATP channels openerOPENERChEMBL
SARAKALIMCHEMBL2104449Sulfonylurea receptors; K-ATP channels openerOPENERChEMBL

Trials15

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07403604DIAZOXIDEPHASE1ClinicalTrials.gov
NCT06606327DIAZOXIDEPHASE1ClinicalTrials.gov
NCT05729282DIAZOXIDEPHASE1ClinicalTrials.gov
NCT03566511DIAZOXIDEPHASE22025-05-31ClinicalTrials.gov
NCT03540758DIAZOXIDEPHASE2ClinicalTrials.gov
NCT02049385DIAZOXIDEPHASE1/PHASE22017-10-13ClinicalTrials.gov
NCT02034071DIAZOXIDEPHASE1/PHASE2ClinicalTrials.gov
NCT01488136DIAZOXIDEPHASE4ClinicalTrials.gov
NCT00994149DIAZOXIDEPHASE2/PHASE3ClinicalTrials.gov
NCT00892073DIAZOXIDEPHASE2ClinicalTrials.gov

1 to 10 of 15

See all 15 trials

NIH grants719

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNJ8 papersNewest fiscal year
R35HL171542Cardiovascular potassium channels: From molecular basis to disease therapeutics42025
P30DK020579Diabetes Research Center32025
R01GM145784Correlating structure and function in KATP channel isoforms32025
R01HL071158Acid, Succinate and Glyoxal Metabolism in Ischemia32025
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL32025
P01AG029531The Aging Pituitary/Gonadal Axis22025
P01AG052350Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's Disease22025
P01HL151328Triglycerides, Diabetes and Cardiovascular Disease22025
P30AR074992RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE22025
P30CA014520UW Comprehensive Cancer Center Support22025

1 to 10 of 719Source NIH's project files

See all 719 nih grants

Papers1,154

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Emerging pharmacological targets in migraine therapy: CGRP and beyond.Front Pharmacol202642781272PubTator, text miningPubMed
From Array-CGH to Whole-Genome Sequencing: A 29-Year Diagnostic Journey Culminating in the Identification of a De Novo ABCC9 Variant Consistent with Cantú Syndrome.Diagnostics (Basel)202642510068PubTator, text miningPubMed
Cardiac ventricular Kir6.1 ATP-sensitive potassium channels: an overlooked effector of cardioprotection.Front Physiol202642088949PubTator, text miningPubMed
[Exogenous nitric oxide suppresses K ATP channel activity through S-nitrosylation].Sheng Wu Yi Xue Gong Cheng Xue Za Zhi202642037343PubTator, text miningPubMed
Biophysical Characterization of a Novel KCNJ8 Rare Variant Linked With Inherited and Acquired J Wave Syndrome.JACC Clin Electrophysiol202641995661PubTator, text miningPubMed
MitoQ Triggers Mitochondrial Collapse and Apoptotic Death in Glioblastoma Associated with KATP Channel Expression Changes.Neurochem Res202641910839PubTator, text miningPubMed
Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx.Theranostics202641799190PubTator, text miningPubMed
PINCH proteins orchestrate vascular mural cell homeostasis through integrated signaling and transcriptional networks.Angiogenesis202641795751PubTator, text miningPubMed
Genetic Variants in Potassium Channel Genes and Their Clinical Implications in Kazakhstani Patients with Cardiac Arrhythmias.J Pers Med202641745353PubTator, text miningPubMed
Aging-Induced QT Prolongation as a Potential Contributor to Longevity.J Cardiovasc Dev Dis202641745334PubTator, text miningPubMed

1 to 10 of 1,154

See all 1,154 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3764

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