Gene · 3766
KCNJ10: potassium inwardly rectifying channel subfamily J member 10
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KCNJ10: potassium inwardly rectifying channel subfamily J member 10. Genes, record 3766. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3766
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P78508 | ATP-sensitive inward rectifier potassium channel 10 | 379 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents57
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58640 | P78508 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 24290 | P78508 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2221 | P78508 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2221 | P78508 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 24290 | P78508 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30335 | P78508 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30338 | P78508 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30339 | P78508 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 30335 | P78508 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 30338 | P78508 | Espacenet |
1 to 10 of 57
See all 57 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,136
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KCNJ10 papers | Newest fiscal year |
|---|---|---|---|
| R01DK051496 | WNK Kinase Regulation of Thiazide-sensitive NaCl Transport | 5 | 2025 |
| R01DK133220 | Role of Kir4.1 in regulating NCC and ROMK in DCT | 5 | 2025 |
| R01DK054231 | Molecular of ROMK Channel Function | 4 | 2025 |
| I01BX004024 | Transport and metabolism in the kidney | 3 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| R01DK093501 | WNK-SPAK signaling in the Distal Nephron | 3 | 2025 |
| R01DK098141 | Regulation of renal ion transport by the CUL3-WNK-SPAK pathway | 3 | 2025 |
| R01DK110358 | Regulation of WNK signaling by potassium and Mo25: structure, function and physiology | 3 | 2025 |
| R35NS111583 | Fundamental astrocyte biology in intact neural circuits | 3 | 2025 |
| P20GM103475 | Advancing Competitive Biomedical Research in Puerto Rico | 2 | 2025 |
1 to 10 of 1,136Source NIH's project files
See all 1,136 nih grantsPapers1,696
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Redistribution of Aquaporin Proteins in Retinal Blood Vessels in Human Diabetic Retinopathy. | Curr Eye Res | 2026 | 42720123 | PubTator, text mining | PubMed |
| The cornea-trigeminal axis: potassium channels as master regulators of ocular surface homeostasis and sensory transduction. | Front Cell Dev Biol | 2026 | 42707580 | PubTator, text mining | PubMed |
| Paroxysmal Kinesigenic Dyskinesia and Progressive Ataxia-Spasticity Syndrome Caused by a Biallelic Variant in KCNJ10. | Mov Disord Clin Pract | 2026 | 42644635 | PubTator, text mining | PubMed |
| Astrocyte-blood-brain barrier crosstalk in cerebral small vessel disease: linking barrier dysfunction to neurovascular failure. | Front Neurol | 2026 | 42621038 | PubTator, text mining | PubMed |
| Type, Location, and Zygosity of KCNJ16 Variants May Determine the Clinical Severity of Hypokalemia Tubulopathy and Deafness. | Kidney360 | 2026 | 42574073 | PubTator, text mining | PubMed |
| Region- and Cell-Specific Vulnerability to ROS After Global Brain Ischemia-Reperfusion Injury: Molecular and Cellular Mechanisms. | Front Biosci (Landmark Ed) | 2026 | 42530241 | PubTator, text mining | PubMed |
| Combinatorial Residue Recognition in SsTx-4 Inhibition of the Kir4.1/5.1 Channel. | Biochemistry | 2026 | 42473198 | PubTator, text mining | PubMed |
| Ionic Homeostasis Failure in Major Depressive Disorder: Ion Channel Mechanisms, Excitation-Inhibition Imbalance, and Precision Therapeutics. | Int J Mol Sci | 2026 | 42450349 | PubTator, text mining | PubMed |
| The kidney distal tubule potassium switch, modern diet and hypertension. | Nat Rev Nephrol | 2026 | 42449179 | PubTator, text mining | PubMed |
| High glucose-induced mitochondrial fission promotes Müller cell activation via suppression of the Hippo pathway. | Mol Cell Biochem | 2026 | 42397510 | PubTator, text mining | PubMed |
1 to 10 of 1,696
See all 1,696 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3766
GET https://conductscience.org/api/genes/v1/3766/patents?page=2