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Gene · 3766

KCNJ10: potassium inwardly rectifying channel subfamily J member 10

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNJ10: potassium inwardly rectifying channel subfamily J member 10. Genes, record 3766. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3766

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Gene

Symbol
KCNJ10
HGNC
Name
potassium inwardly rectifying channel subfamily J member 10
HGNC
NCBI Gene ID
3766
NCBI Gene
HGNC ID
HGNC:6256
HGNC
Ensembl
ENSG00000177807
NCBI Gene
Aliases
BIRK-10, KCNJ13-PEN, KIR1.2, KIR4.1, Kir1.2, Kir4.1, SESAME
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P78508ATP-sensitive inward rectifier potassium channel 103795Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458640P78508Espacenet
EP 4641201 A22025-10-2924290P78508Espacenet
JP 2025529142 A2025-09-042221P78508Espacenet
US 12371689 B22025-07-292221P78508Espacenet
JP 2025517969 A2025-06-1224290P78508Espacenet
JP 2025032204 A2025-03-1130335P78508Espacenet
JP 2025032204 A2025-03-1130338P78508Espacenet
JP 2025032204 A2025-03-1130339P78508Espacenet
EP 4461818 A22024-11-1330335P78508Espacenet
EP 4461818 A22024-11-1330338P78508Espacenet

1 to 10 of 57

See all 57 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,136

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNJ10 papersNewest fiscal year
R01DK051496WNK Kinase Regulation of Thiazide-sensitive NaCl Transport52025
R01DK133220Role of Kir4.1 in regulating NCC and ROMK in DCT52025
R01DK054231Molecular of ROMK Channel Function42025
I01BX004024Transport and metabolism in the kidney32025
P30CA021765Cancer Center Support Grant (CCSG)32025
R01DK093501WNK-SPAK signaling in the Distal Nephron32025
R01DK098141Regulation of renal ion transport by the CUL3-WNK-SPAK pathway32025
R01DK110358Regulation of WNK signaling by potassium and Mo25: structure, function and physiology32025
R35NS111583Fundamental astrocyte biology in intact neural circuits32025
P20GM103475Advancing Competitive Biomedical Research in Puerto Rico22025

1 to 10 of 1,136Source NIH's project files

See all 1,136 nih grants

Papers1,696

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Redistribution of Aquaporin Proteins in Retinal Blood Vessels in Human Diabetic Retinopathy.Curr Eye Res202642720123PubTator, text miningPubMed
The cornea-trigeminal axis: potassium channels as master regulators of ocular surface homeostasis and sensory transduction.Front Cell Dev Biol202642707580PubTator, text miningPubMed
Paroxysmal Kinesigenic Dyskinesia and Progressive Ataxia-Spasticity Syndrome Caused by a Biallelic Variant in KCNJ10.Mov Disord Clin Pract202642644635PubTator, text miningPubMed
Astrocyte-blood-brain barrier crosstalk in cerebral small vessel disease: linking barrier dysfunction to neurovascular failure.Front Neurol202642621038PubTator, text miningPubMed
Type, Location, and Zygosity of KCNJ16 Variants May Determine the Clinical Severity of Hypokalemia Tubulopathy and Deafness.Kidney360202642574073PubTator, text miningPubMed
Region- and Cell-Specific Vulnerability to ROS After Global Brain Ischemia-Reperfusion Injury: Molecular and Cellular Mechanisms.Front Biosci (Landmark Ed)202642530241PubTator, text miningPubMed
Combinatorial Residue Recognition in SsTx-4 Inhibition of the Kir4.1/5.1 Channel.Biochemistry202642473198PubTator, text miningPubMed
Ionic Homeostasis Failure in Major Depressive Disorder: Ion Channel Mechanisms, Excitation-Inhibition Imbalance, and Precision Therapeutics.Int J Mol Sci202642450349PubTator, text miningPubMed
The kidney distal tubule potassium switch, modern diet and hypertension.Nat Rev Nephrol202642449179PubTator, text miningPubMed
High glucose-induced mitochondrial fission promotes Müller cell activation via suppression of the Hippo pathway.Mol Cell Biochem202642397510PubTator, text miningPubMed

1 to 10 of 1,696

See all 1,696 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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