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Gene · 3767

KCNJ11: potassium inwardly rectifying channel subfamily J member 11

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. KCNJ11: potassium inwardly rectifying channel subfamily J member 11. Genes, record 3767. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/3767

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
KCNJ11
HGNC
Name
potassium inwardly rectifying channel subfamily J member 11
HGNC
NCBI Gene ID
3767
NCBI Gene
HGNC ID
HGNC:6257
HGNC
Ensembl
ENSG00000187486
NCBI Gene
Aliases
BIR, HHF2, IKATP, KIR6.2, Kir6.2, MODY13, PHHI, PNDM2, TNDM3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14654ATP-sensitive inward rectifier potassium channel 113909Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458641Q14654Espacenet
EP 4640849 A22025-10-291026Q14654Espacenet
EP 4641201 A22025-10-296873Q14654Espacenet
JP 2025519096 A2025-06-241026Q14654Espacenet
JP 2025517969 A2025-06-126873Q14654Espacenet
US 11446398 B22022-09-2065613Q14654Espacenet
US 11400116 B22022-08-02151Q14654Espacenet
JP 2022524081 A2022-04-27168584Q14654Espacenet
US 11078247 B22021-08-035743Q14654Espacenet
JP 2019054813 A2019-04-11239076Q14654Espacenet

1 to 10 of 20

See all 20 patents

Drugs19

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACETOHEXAMIDECHEMBL1589Sulfonylurea receptor 1, Kir6.2 blockerBLOCKERChEMBL
CHLORPROPAMIDECHEMBL498Sulfonylurea receptor 1, Kir6.2 blockerBLOCKERChEMBL
DIAZOXIDECHEMBL181Potassium channel, inwardly rectifying, subfamily J, member 11 openerOPENERChEMBL
GLICLAZIDECHEMBL427216Sulfonylurea receptor 1, Kir6.2 blockerBLOCKERChEMBL
GLIMEPIRIDECHEMBL1481Sulfonylurea receptor 1, Kir6.2 blockerBLOCKERChEMBL
GLIPIZIDECHEMBL1073Sulfonylurea receptor 1, Kir6.2 blockerBLOCKERChEMBL
GLYBURIDECHEMBL472Sulfonylurea receptor 1, Kir6.2 blockerBLOCKERChEMBL
MINOXIDILCHEMBL802Sulfonylurea receptor 2, Kir6.2 openerOPENERChEMBL
MITIGLINIDECHEMBL471498Sulfonylurea receptor 1, Kir6.2 blockerBLOCKERChEMBL
MITIGLINIDE CALCIUM DIHYDRATECHEMBL4298005Sulfonylurea receptor 1, Kir6.2 blockerBLOCKERChEMBL

1 to 10 of 19

See all 19 drugs

Trials347

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants2,332

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30DK020595Diabetes Research and Training Center392025
P30DK020579Diabetes Research Center182025
P30DK063491Diabetes Research Center (DRC)162025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION162025
P30DK020572Michigan Diabetes Research Center (MDRC)152025
ZIAHG000024Genetic analysis of type II diabetes152025
R01DK093757Genetic epidemiology of rare and regulatory variants for metabolic traits122025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal122025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)112025
P30CA068485Cancer Center Support Grant92025

1 to 10 of 2,332Source NIH's project files

See all 2,332 nih grants

Papers4,332

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821652PubTator, text miningPubMed
42811839PubTator, text miningPubMed
42780966PubTator, text miningPubMed
42758052PubTator, text miningPubMed
42723843PubTator, text miningPubMed
42663520PubTator, text miningPubMed
42609583PubTator, text miningPubMed
42608944PubTator, text miningPubMed
42546565PubTator, text miningPubMed
42502247PubTator, text miningPubMed

1 to 10 of 4,332

See all 4,332 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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