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KCNK2: potassium two pore domain channel subfamily K member 2
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Gene · 3776

Papers1,439

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 1,439

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TitleJournalYearPMIDFound bySource
A hypothalamic neuronal population coordinates metabolic adaptations to cold.Neuron202642790426PubTator, text miningPubMed
A conserved conformation-dependent mechanism for the TREK two-pore domain potassium channel inhibitors carvedilol and fluphenazine.Mol Pharmacol202642772120PubTator, text miningPubMed
K2P channels as emerging therapeutic targets for pain: insights from functional studies and transcriptomic analyses.Front Pharmacol202642756049PubTator, text miningPubMed
Magnetic nanoparticle formulations to activate TREK and Piezo mechanosensitive ion channels (MICA) for enhanced osteogenesis.Regen Biomater202642636326PubTator, text miningPubMed
A TREK that activates thermogenic adipose tissue by sensing cold air in the lung.Dev Cell202642586049PubTator, text miningPubMed
Mosapride promotes internalization of a TREK1-HTR4 complex and exerts rapid antidepressant-like effects.Mol Psychiatry202642542439PubTator, text miningPubMed
Mechanosensitive ion channels in immunity from biophysics to mechanomedicine.Biophys J202642522197PubTator, text miningPubMed
Disentangling Sex Differences in Sulfonylurea Drug Response With Genome-Wide Association Studies in Individuals With Type 2 Diabetes.Clin Pharmacol Ther202642504935PubTator, text miningPubMed
A TREK-1/AQP4/TRPA1/BDNF Signaling Axis Is Associated With Astrocytic Volume Transients, Synaptic Plasticity, and Spatial Memory.Glia202642458823PubTator, text miningPubMed
Ionic Homeostasis Failure in Major Depressive Disorder: Ion Channel Mechanisms, Excitation-Inhibition Imbalance, and Precision Therapeutics.Int J Mol Sci202642450349PubTator, text miningPubMed
The potential mechanisms of exercise-regulated mechanically sensitive ion channels in promoting spinal cord injury repair: a hypothesis-driven narrative review.Rev Neurosci202642370596PubTator, text miningPubMed
Aberrant Potassium Handling by Astrocytes and Epileptic Seizures: A Synthetic Update.Acta Physiol (Oxf)202642267896PubTator, text miningPubMed
Role for TREK-1 as a polymodal sensor and regulator of cell activity.Channels (Austin)202642153246PubTator, text miningPubMed
Activation of TREK-1 and TREK-2 Two-Pore Domain Potassium Channels by the Kv4 Channel Modulator, NS5806.Pharmacol Res Perspect202642135999PubTator, text miningPubMed
Gating shift to an ohmic mode of TREK-1 channel induced by docosahexaenoic acid.Biophys J202642099013PubTator, text miningPubMed
K2P Channels as Key Regulators of Cardiovascular and Pulmonary Vascular Function.Pharmaceuticals (Basel)202642075790PubTator, text miningPubMed
Microwaves stimulate and inhibit neurons via modulation of TRPV and TREK channels.J Neural Eng202642013877PubTator, text miningPubMed
Pathophysiology of homocysteine: insights into ion channel dysfunction.Pflugers Arch202641915221PubTator, text miningPubMed
A Comprehensive Study of Xenon Anesthesia in Patients with Locally Advanced Gastric Cancer: A Single-Center Study.Med Sci (Basel)202641892861PubTator, text miningPubMed
When dreams feel real: the MÖBIUS model.Commun Biol202641872455PubTator, text miningPubMed

gene-search-2026-11-11-0.2.0

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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