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Gene · 3776

KCNK2: potassium two pore domain channel subfamily K member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNK2: potassium two pore domain channel subfamily K member 2. Genes, record 3776. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3776

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Gene

Symbol
KCNK2
HGNC
Name
potassium two pore domain channel subfamily K member 2
HGNC
NCBI Gene ID
3776
NCBI Gene
HGNC ID
HGNC:6277
HGNC
Ensembl
ENSG00000082482
NCBI Gene
Aliases
K2p2.1, TPKC1, TREK, TREK-1, TREK1, hTREK-1c, hTREK-1e
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95069Potassium channel subfamily K member 24261Ensembl, GeneID, HGNC

Source UniProt

Patents14

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458589O95069Espacenet
EP 4650780 A22025-11-1912616O95069Espacenet
EP 4641201 A22025-10-2913937O95069Espacenet
JP 2025529142 A2025-09-042243O95069Espacenet
US 12371689 B22025-07-292243O95069Espacenet
JP 2025517969 A2025-06-1213937O95069Espacenet
JP 2025517970 A2025-06-1212616O95069Espacenet
US 11446398 B22022-09-2065712O95069Espacenet
US 11400116 B22022-08-02644O95069Espacenet
JP 2022524081 A2022-04-27168683O95069Espacenet

1 to 10 of 14

See all 14 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DESFLURANECHEMBL1200733Potassium channel subfamily K member 2 openerOPENERChEMBL
ENFLURANECHEMBL1257Potassium channel subfamily K member 2 openerOPENERChEMBL
HALOTHANECHEMBL931Potassium channel subfamily K member 2 openerOPENERChEMBL
ISOFLURANECHEMBL1256Potassium channel subfamily K member 2 openerOPENERChEMBL
SEVOFLURANECHEMBL1200694Potassium channel subfamily K member 2 openerOPENERChEMBL

Trials168

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants863

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNK2 papersNewest fiscal year
R01MH093603Genetic and chemical biological studies of K2P structure, function, andmodulation122025
P30EY014800University of Utah Core Vision Research Grant72025
R01EY027920Molecular mechanisms of mechanotransduction in the aqueous outflow pathway72025
P30EY014801Miami Center for Vision Research52025
T32EY024234Vision Research Training Grant at the University of Utah42025
P30EY005722Center Core Grant for Vision Research32025
R01HL059949Structural Determinants of PIP2 Regulation32025
K12HD047349Pediatric Critical Care and Trauma Scientist Development Program (PCCTSDP)22025
P30EY003176UC Berkeley Vision Science CORE22025
P30EY008126Core Grant in Vision Research22025

1 to 10 of 863Source NIH's project files

See all 863 nih grants

Papers1,439

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A hypothalamic neuronal population coordinates metabolic adaptations to cold.Neuron202642790426PubTator, text miningPubMed
A conserved conformation-dependent mechanism for the TREK two-pore domain potassium channel inhibitors carvedilol and fluphenazine.Mol Pharmacol202642772120PubTator, text miningPubMed
K2P channels as emerging therapeutic targets for pain: insights from functional studies and transcriptomic analyses.Front Pharmacol202642756049PubTator, text miningPubMed
Magnetic nanoparticle formulations to activate TREK and Piezo mechanosensitive ion channels (MICA) for enhanced osteogenesis.Regen Biomater202642636326PubTator, text miningPubMed
A TREK that activates thermogenic adipose tissue by sensing cold air in the lung.Dev Cell202642586049PubTator, text miningPubMed
Mosapride promotes internalization of a TREK1-HTR4 complex and exerts rapid antidepressant-like effects.Mol Psychiatry202642542439PubTator, text miningPubMed
Mechanosensitive ion channels in immunity from biophysics to mechanomedicine.Biophys J202642522197PubTator, text miningPubMed
Disentangling Sex Differences in Sulfonylurea Drug Response With Genome-Wide Association Studies in Individuals With Type 2 Diabetes.Clin Pharmacol Ther202642504935PubTator, text miningPubMed
A TREK-1/AQP4/TRPA1/BDNF Signaling Axis Is Associated With Astrocytic Volume Transients, Synaptic Plasticity, and Spatial Memory.Glia202642458823PubTator, text miningPubMed
Ionic Homeostasis Failure in Major Depressive Disorder: Ion Channel Mechanisms, Excitation-Inhibition Imbalance, and Precision Therapeutics.Int J Mol Sci202642450349PubTator, text miningPubMed

1 to 10 of 1,439

See all 1,439 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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