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Gene · 3777

KCNK3: potassium two pore domain channel subfamily K member 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNK3: potassium two pore domain channel subfamily K member 3. Genes, record 3777. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3777

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Gene

Symbol
KCNK3
HGNC
Name
potassium two pore domain channel subfamily K member 3
HGNC
NCBI Gene ID
3777
NCBI Gene
HGNC ID
HGNC:6278
HGNC
Ensembl
ENSG00000171303
NCBI Gene
Aliases
DDSA, K2p3.1, OAT1, PPH4, TASK, TASK-1, TASK1, TBAK1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14649Potassium channel subfamily K member 33944Ensembl, GeneID, HGNC

Source UniProt

Patents53

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026027383 A2026-02-1834O14649Espacenet
JP 2026004568 A2026-01-1458593O14649Espacenet
EP 4650780 A22025-11-194408O14649Espacenet
WO 2025186311 A12025-09-121O14649Espacenet
JP 2025529142 A2025-09-042244O14649Espacenet
US 12371689 B22025-07-292244O14649Espacenet
JP 2025517970 A2025-06-124408O14649Espacenet
JP 2025032204 A2025-03-1130364O14649Espacenet
EP 4461818 A22024-11-1330364O14649Espacenet
JP 2024128028 A2024-09-2015O14649Espacenet

1 to 10 of 53

See all 53 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DESFLURANECHEMBL1200733Potassium channel subfamily K member 3 openerOPENERChEMBL
DOXAPRAMCHEMBL1754Potassium channel subfamily K member 3 blockerBLOCKERChEMBL
DOXAPRAM HYDROCHLORIDECHEMBL3989519Potassium channel subfamily K member 3 blockerBLOCKERChEMBL
ENFLURANECHEMBL1257Potassium channel subfamily K member 3 openerOPENERChEMBL
HALOTHANECHEMBL931Potassium channel subfamily K member 3 openerOPENERChEMBL
ISOFLURANECHEMBL1256Potassium channel subfamily K member 3 openerOPENERChEMBL
SEVOFLURANECHEMBL1200694Potassium channel subfamily K member 3 openerOPENERChEMBL

Trials170

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,556

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNK3 papersNewest fiscal year
P30DK063491Diabetes Research Center (DRC)82025
R01HL124021An endothelial-fibroblast axis connecting senescence to amino acid metabolism for control of vascular stiffness in PAH52025
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation52025
P01CA196569Statistical Methods for Integrative Genomics in Cancer42025
P30DK036836Diabetes Research Center42025
R01GM024663Genetic Analysis of Nematode Egg Laying and Co-regulated Behavioral Systems42025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal42025
R01MH093603Genetic and chemical biological studies of K2P structure, function, andmodulation42025
T15LM011271San Diego Biomedical Informatics Education & Research (SABER)42025
UL1TR001863Yale Clinical and Translational Science Award42025

1 to 10 of 1,556Source NIH's project files

See all 1,556 nih grants

Papers1,851

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting the miR-3156-3p/K+ channel axis suppresses viral release and paralysis in enterovirus D68 infection.Mol Ther202642817166PubTator, text miningPubMed
An unexpected therapeutic overlap: long-term control of KCNK3-associated pulmonary arterial hypertension during treatment of systemic hypertension-a case report.Eur Heart J Case Rep202642781697PubTator, text miningPubMed
Mapping the Immune cell-specific gene regulatory network in bipolar disorder: A framework from scTWMR to exploratory drug-target annotation.Psychiatry Res202642743600PubTator, text miningPubMed
An integrated single-cell and Mendelian randomization analysis of stromal features in Asherman's syndrome and endometrial cancer.Cancer Treat Res Commun202642727551PubTator, text miningPubMed
Identification of Causal Plasma Proteins and Immune Mediators for Lung Cancer in Never-Smokers: A Large-Scale Integrative Analysis Combining Mendelian Randomization, Colocalization, and Mediation.Curr Med Chem202642708309PubTator, text miningPubMed
In vitro assessments for pharmacokinetic drug-drug interaction potential of vornorexant, a novel dual orexin 1/2 receptor antagonist.Xenobiotica202642693680PubTator, text miningPubMed
Integrative Multi-Omics Mendelian Randomization Analysis Identifies NIT2 as a Potential Metabolic Risk Gene in Hepatocellular Carcinoma.J Gene Med202642681890PubTator, text miningPubMed
Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.J Precis Med (Amst)202642644057PubTator, text miningPubMed
Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study.Diabetes Obes Metab202642638160PubTator, text miningPubMed
Elucidating the proteomic pathways linking childhood body mass index with type 2 diabetes: a Mendelian randomization and recall-by-genotype study.Int J Epidemiol202642613030PubTator, text miningPubMed

1 to 10 of 1,851

See all 1,851 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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