Gene · 3777
KCNK3: potassium two pore domain channel subfamily K member 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KCNK3: potassium two pore domain channel subfamily K member 3. Genes, record 3777. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3777
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14649 | Potassium channel subfamily K member 3 | 394 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents53
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026027383 A | 2026-02-18 | 34 | O14649 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58593 | O14649 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4408 | O14649 | Espacenet |
| WO 2025186311 A1 | 2025-09-12 | 1 | O14649 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2244 | O14649 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2244 | O14649 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4408 | O14649 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30364 | O14649 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 30364 | O14649 | Espacenet |
| JP 2024128028 A | 2024-09-20 | 15 | O14649 | Espacenet |
1 to 10 of 53
See all 53 patentsDrugs7
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| DESFLURANE | CHEMBL1200733 | Potassium channel subfamily K member 3 opener | OPENER | ChEMBL |
| DOXAPRAM | CHEMBL1754 | Potassium channel subfamily K member 3 blocker | BLOCKER | ChEMBL |
| DOXAPRAM HYDROCHLORIDE | CHEMBL3989519 | Potassium channel subfamily K member 3 blocker | BLOCKER | ChEMBL |
| ENFLURANE | CHEMBL1257 | Potassium channel subfamily K member 3 opener | OPENER | ChEMBL |
| HALOTHANE | CHEMBL931 | Potassium channel subfamily K member 3 opener | OPENER | ChEMBL |
| ISOFLURANE | CHEMBL1256 | Potassium channel subfamily K member 3 opener | OPENER | ChEMBL |
| SEVOFLURANE | CHEMBL1200694 | Potassium channel subfamily K member 3 opener | OPENER | ChEMBL |
Trials170
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07602400 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07568938 | DESFLURANE | ClinicalTrials.gov | ||
| NCT07513870 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07457593 | ISOFLURANE | ClinicalTrials.gov | ||
| NCT07440758 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07440758 | DESFLURANE | ClinicalTrials.gov | ||
| NCT07338578 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07313969 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07304206 | SEVOFLURANE | ClinicalTrials.gov | ||
| NCT07271472 | DESFLURANE | ClinicalTrials.gov |
1 to 10 of 170
See all 170 trialsNIH grants1,556
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KCNK3 papers | Newest fiscal year |
|---|---|---|---|
| P30DK063491 | Diabetes Research Center (DRC) | 8 | 2025 |
| R01HL124021 | An endothelial-fibroblast axis connecting senescence to amino acid metabolism for control of vascular stiffness in PAH | 5 | 2025 |
| R01HL131517 | Sex-specific arrhythmogenic mechanisms of atrial fibrillation | 5 | 2025 |
| P01CA196569 | Statistical Methods for Integrative Genomics in Cancer | 4 | 2025 |
| P30DK036836 | Diabetes Research Center | 4 | 2025 |
| R01GM024663 | Genetic Analysis of Nematode Egg Laying and Co-regulated Behavioral Systems | 4 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 4 | 2025 |
| R01MH093603 | Genetic and chemical biological studies of K2P structure, function, andmodulation | 4 | 2025 |
| T15LM011271 | San Diego Biomedical Informatics Education & Research (SABER) | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
1 to 10 of 1,556Source NIH's project files
See all 1,556 nih grantsPapers1,851
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Targeting the miR-3156-3p/K+ channel axis suppresses viral release and paralysis in enterovirus D68 infection. | Mol Ther | 2026 | 42817166 | PubTator, text mining | PubMed |
| An unexpected therapeutic overlap: long-term control of KCNK3-associated pulmonary arterial hypertension during treatment of systemic hypertension-a case report. | Eur Heart J Case Rep | 2026 | 42781697 | PubTator, text mining | PubMed |
| Mapping the Immune cell-specific gene regulatory network in bipolar disorder: A framework from scTWMR to exploratory drug-target annotation. | Psychiatry Res | 2026 | 42743600 | PubTator, text mining | PubMed |
| An integrated single-cell and Mendelian randomization analysis of stromal features in Asherman's syndrome and endometrial cancer. | Cancer Treat Res Commun | 2026 | 42727551 | PubTator, text mining | PubMed |
| Identification of Causal Plasma Proteins and Immune Mediators for Lung Cancer in Never-Smokers: A Large-Scale Integrative Analysis Combining Mendelian Randomization, Colocalization, and Mediation. | Curr Med Chem | 2026 | 42708309 | PubTator, text mining | PubMed |
| In vitro assessments for pharmacokinetic drug-drug interaction potential of vornorexant, a novel dual orexin 1/2 receptor antagonist. | Xenobiotica | 2026 | 42693680 | PubTator, text mining | PubMed |
| Integrative Multi-Omics Mendelian Randomization Analysis Identifies NIT2 as a Potential Metabolic Risk Gene in Hepatocellular Carcinoma. | J Gene Med | 2026 | 42681890 | PubTator, text mining | PubMed |
| Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart. | J Precis Med (Amst) | 2026 | 42644057 | PubTator, text mining | PubMed |
| Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study. | Diabetes Obes Metab | 2026 | 42638160 | PubTator, text mining | PubMed |
| Elucidating the proteomic pathways linking childhood body mass index with type 2 diabetes: a Mendelian randomization and recall-by-genotype study. | Int J Epidemiol | 2026 | 42613030 | PubTator, text mining | PubMed |
1 to 10 of 1,851
See all 1,851 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3777
GET https://conductscience.org/api/genes/v1/3777/patents?page=2