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Gene · 3778

KCNMA1: potassium calcium-activated channel subfamily M alpha 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNMA1: potassium calcium-activated channel subfamily M alpha 1. Genes, record 3778. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3778

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Gene

Symbol
KCNMA1
HGNC
Name
potassium calcium-activated channel subfamily M alpha 1
HGNC
NCBI Gene ID
3778
NCBI Gene
HGNC ID
HGNC:6284
HGNC
Ensembl
ENSG00000156113
NCBI Gene
Aliases
BKTM, CADEDS, IEG16, KCa1.1, LIWAS, MaxiK, PNKD3, SAKCA, SLO, SLO-ALPHA, SLO1, bA205K10.1, hSlo, mSLO1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q12791Calcium-activated potassium channel subunit alpha-11,23636Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-292873Q12791Espacenet
JP 2025529142 A2025-09-042250Q12791Espacenet
US 12371689 B22025-07-292250Q12791Espacenet
JP 2025517969 A2025-06-122873Q12791Espacenet
JP 2025032204 A2025-03-1130409Q12791Espacenet
EP 4461818 A22024-11-1330409Q12791Espacenet
JP 2023058610 A2023-04-2530409Q12791Espacenet
US 11446398 B22022-09-2065586Q12791Espacenet
WO 2022176958 A2022-08-251Q12791Espacenet
US 11400116 B22022-08-022002Q12791Espacenet

1 to 10 of 19

See all 19 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ANDOLASTCHEMBL119549Calcium-activated potassium channel subunit alpha-1 activatorACTIVATORChEMBL
BMS-223131CHEMBL222460Calcium-activated potassium channel subunit alpha-1 activatorACTIVATORChEMBL
FLINDOKALNERCHEMBL266510Calcium-activated potassium channel subunit alpha-1 openerOPENERChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,689

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNMA1 papersNewest fiscal year
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant82025
R01AA011560Ethanol actions on slo channels from arteries vs. brain.72025
R01MH085927Synaptic function of BK channel-interacting proteins72025
P40OD010440Caenorhabditis Genetics Center62025
R01GM030376The Electrophysiological Studies of Voltage Gated Channels62025
P30CA008748Cancer Center Support Grant52025
P50AA022537Cross-species investigation of gene networks for ethanol-related behaviors52025
R01HD038082Sperm Ca2+ signaling and energy pathways in basic science and ART52025
R01DC001919Expression of Ion Channels in the Auditory System42025
R01HL071158Acid, Succinate and Glyoxal Metabolism in Ischemia42025

1 to 10 of 1,689Source NIH's project files

See all 1,689 nih grants

Papers2,519

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
[Identification of immune key genes in sepsis and the regulatory effects of dexmedetomidine based on transcriptome analysis and machine learning].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi202642750326PubTator, text miningPubMed
Structural underpinnings of human Slo1 inhibition by scorpion and fungal toxins.Proc Natl Acad Sci U S A202642735318PubTator, text miningPubMed
Site and mechanism of BK channel inhibition and cerebral artery constriction by pregnenolone.Pharmacol Res202642633875PubTator, text miningPubMed
Identification of specific host cell potassium ion channels that mediate escape of bunyamwera virus from late endosome compartments.J Biol Chem202642520941PubTator, text miningPubMed
Integrated transcriptomic and immune analysis reveals distinct mitochondrial and immune signature in COVID-19 ARDS requiring invasive mechanical ventilation.Front Med (Lausanne)202642487974PubTator, text miningPubMed
The heterogeneity of dopamine-mediated vasodilation in human intrarenal arteries.J Adv Res202642331318PubTator, text miningPubMed
Identification of a Novel Genetic Variant Responsible for Familial Atrial Fibrillation.Can J Cardiol202642263934PubTator, text miningPubMed
Case report: Whole-exome sequencing reveals a novel variant in a patient with epilepsy presenting with fever.Front Genet202642245406PubTator, text miningPubMed
Dynamic calcium-potassium balancing by KCNMA1 preserves the epithelial/mesenchymal hybrid state and modulates therapy response in ovarian cancer.Cell Death Discov202642243091PubTator, text miningPubMed
BK Channels Orchestrate Cardiac Homeostasis Through Mitochondrial Uncoupling Proteins.bioRxiv202642239398PubTator, text miningPubMed

1 to 10 of 2,519

See all 2,519 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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