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Gene · 378

ARF4: ARF GTPase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ARF4: ARF GTPase 4. Genes, record 378. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/378

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Gene

Symbol
ARF4
HGNC
Name
ARF GTPase 4
HGNC
NCBI Gene ID
378
NCBI Gene
HGNC ID
HGNC:655
HGNC
Ensembl
ENSG00000168374
NCBI Gene
Aliases
ARF2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P18085ADP-ribosylation factor 41801Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436767P18085Espacenet
EP 4650780 A22025-11-194392P18085Espacenet
JP 2025517970 A2025-06-124392P18085Espacenet
JP 2025062604 A2025-04-143219P18085Espacenet
JP 2025032204 A2025-03-1124623P18085Espacenet
EP 4461818 A22024-11-1324623P18085Espacenet
JP 2023058610 A2023-04-2524623P18085Espacenet
US 11446398 B22022-09-203219P18085Espacenet
JP 2022524081 A2022-04-27106190P18085Espacenet
US 11078247 B22021-08-03693P18085Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants617

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleARF4 papersNewest fiscal year
ZIABC007365Regulation of ADP-ribosylation factor92025
P30CA016672Cancer Center Support Grant42025
P30CA008748Cancer Center Support Grant32025
R01GM060992Intraflagellar Transport Proteins in Mice32025
P30CA006927Comprehensive Cancer Center Program at Fox Chase22025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center22025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control22025
R01CA268179Functional interplay between Hippo and estrogen receptor ESR122025
R01DK064380Molecular Mechanisms Regulating Epithelial Cell Apical Polarity and Ciliogenesis22025
R01GM089933Quality Control of the cilia proteome22025

1 to 10 of 617Source NIH's project files

See all 617 nih grants

Papers821

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Beyond auxin responses: a miR160-ARF4 module regulates the biogenesis of medicinal saponins.Plant Physiol202642816431PubTator, text miningPubMed
High-Throughput Acoustic FFPE Proteomics Reveals ATP5IF1-Associated Mitochondrial Alterations in Acral Melanoma.Mol Cell Proteomics202642442611PubTator, text miningPubMed
Navigating luminal heterogeneity: etiology-based proteogenomic subtyping for targeted treatment strategies in breast cancer.Mol Cancer202642237381PubTator, text miningPubMed
MAPK pathway inhibitors enhance radioiodine sensitivity in anaplastic thyroid carcinoma through promoting NIS expression and ARF4-mediated NIS membrane transport.Sci Rep202642236533PubTator, text miningPubMed
Heme oxygenase-1 attenuates sepsis-associated acute lung injury by suppressing the CREB3/ARF4 signaling pathway to mitigate Golgi stress in macrophages.Free Radic Biol Med202641967721PubTator, text miningPubMed
Newcastle disease virus exploits Golgi stress and Golgiphagy to promote ferroptosis.Autophagy202641961065PubTator, text miningPubMed
Endothelial Cell Secretome Alterations Induced by Inflammatory Stress.bioRxiv202641648605PubTator, text miningPubMed
Therapeutic Potential of Tyrosine Kinase Inhibitors in Advanced Thyroid Cancer.Curr Oncol Rep202641642503PubTator, text miningPubMed
Dysregulated expression of the tumor suppressor p14ARF in cancer provides an effective target for TCR-T cell therapeutics.J Immunother Cancer202641638872PubTator, text miningPubMed
Breast Cancer-Secreted DPP3 Promotes Lung Metastasis by Remodelling the Vascular Niche in Lung via the Rap1 Signalling Pathway.J Extracell Vesicles202541311249PubTator, text miningPubMed

1 to 10 of 821

See all 821 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/378

GET https://conductscience.org/api/genes/v1/378/patents?page=2