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KCNQ1: potassium voltage-gated channel subfamily Q member 1

1 protein, 69 patents, 8 drugs, 96 trials, 3,527 NIH grants and 6,603 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolKCNQ1HGNC
Namepotassium voltage-gated channel subfamily Q member 1HGNC
NCBI Gene ID3784NCBI Gene
HGNC IDHGNC:6294HGNC
EnsemblENSG00000053918NCBI Gene
AliasesATFB1, ATFB3, JLNS1, KCNA8, KCNA9, KVLQT1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, WRSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P51787Potassium voltage-gated channel subfamily KQT member 167628Ensembl, GeneID, HGNCUniProt

Patents 69

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458727P51787Espacenet
EP 4640849 A22025-10-299P51787Espacenet
EP 4641201 A22025-10-2980P51787Espacenet
EP 4641202 A22025-10-296P51787Espacenet
JP 2025532979 A2025-10-03102P51787Espacenet
JP 2025529142 A2025-09-042259P51787Espacenet
EP 4593850 A22025-08-06102P51787Espacenet
US 12371689 B22025-07-292259P51787Espacenet
JP 2025519096 A2025-06-249P51787Espacenet
JP 2025517969 A2025-06-1280P51787Espacenet

Drugs 8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
EZOGABINECHEMBL41355KCNQ (Kv7) potassium channel openerOPENERChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL
NERISPIRDINECHEMBL2107762Voltage-gated potassium channel blockerBLOCKERChEMBL
TEDISAMILCHEMBL113461Voltage-gated potassium channel blockerBLOCKERChEMBL

Trials 96

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06333171DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06294821DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06136728DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT05919407AMIFAMPRIDINEPHASE3ClinicalTrials.gov

NIH grants 3527

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL122010Decrypting Variants of Uncertain Significance in Long-QT Syndrome332,025NIH's project files
P30DK063491Diabetes Research Center (DRC)242,025NIH's project files
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL212,025NIH's project files
P30CA068485Cancer Center Support Grant152,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility152,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)142,025NIH's project files
R35GM126935EPR Spectroscopic Studies of Membrane Proteins142,025NIH's project files
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION132,025NIH's project files
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal122,025NIH's project files
R01HL121253L-type channel trafficking and modulation in heart122,025NIH's project files

Papers 6603

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826183PubTator, text miningPubMed
42816482PubTator, text miningPubMed
42798645PubTator, text miningPubMed
42790796PubTator, text miningPubMed
42780784PubTator, text miningPubMed
42763977PubTator, text miningPubMed
42669865PubTator, text miningPubMed
42653690PubTator, text miningPubMed
42647063PubTator, text miningPubMed
42644057PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license