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Gene · 379

ARL4D: ARF like GTPase 4D

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ARL4D: ARF like GTPase 4D. Genes, record 379. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/379

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Gene

Symbol
ARL4D
HGNC
Name
ARF like GTPase 4D
HGNC
NCBI Gene ID
379
NCBI Gene
HGNC ID
HGNC:656
HGNC
Ensembl
ENSG00000175906
NCBI Gene
Aliases
ARF4L
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49703ADP-ribosylation factor-like protein 4D2010Ensembl, GeneID, HGNC

Source UniProt

Patents13

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436802P49703Espacenet
EP 4650780 A22025-11-195448P49703Espacenet
JP 2025517970 A2025-06-125448P49703Espacenet
JP 2025062604 A2025-04-143380P49703Espacenet
JP 2022147356 A2022-10-06308P49703Espacenet
US 11446398 B22022-09-203380P49703Espacenet
JP 2022524081 A2022-04-27106351P49703Espacenet
US 11078247 B22021-08-03771P49703Espacenet
JP 2019158777 A2019-09-19952P49703Espacenet
JP 2019054813 A2019-04-11217237P49703Espacenet

1 to 10 of 13

See all 13 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants236

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleARL4D papersNewest fiscal year
P30CA016086Cancer Center Support Grant22025
P30CA046934University of Colorado Cancer Center Support Grant22025
R01AG050986Higher Order Chromatin and Genetic Risk for Alzheimer's Disease22025
R01CA268179Functional interplay between Hippo and estrogen receptor ESR122025
ZICES102445Gene Expression and Microarrays22025
K12HD000850Pediatric Scientist Development Program12025
K12HD052892Molecular Basis of Pediatric Disease12025
P01CA013106Targeting Transcription and Splicing in Cancer12025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes12025
P01CA234228APOBEC Mutagenesis in Cancer12025

1 to 10 of 236Source NIH's project files

See all 236 nih grants

Papers218

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Single-Cell Landscape Change in Cervical Epithelial Cells and Microenvironment During the Transformation from CINIII to Cervical Squamous Cell Carcinoma.Cancers (Basel)202642193032PubTator, text miningPubMed
Utilising Machine Learning and Single-Cell Analysis to Uncover SKCM Metastasis-Related Genes.IET Syst Biol202641961982PubTator, text miningPubMed
Phosphatidylinositol 4,5-bisphosphate mediates Arl4D self-interaction to promote Pak1 signaling.Proc Natl Acad Sci U S A202641779780PubTator, text miningPubMed
TBC1D15 functions as an Arl4D GAP and promotes the mitochondrial translocation of Arl4D for organelle homeostasis.J Cell Sci202641709823PubTator, text miningPubMed
The phosphorylation of Pak1 by Erk1/2 to drive cell migration requires Arl4D acting as a scaffolding protein.J Cell Sci202540309925PubTator, text miningPubMed
Integration of CRISPR/dCas9-Based methylation editing with guide positioning sequencing identifies dynamic changes of mrDEGs in breast cancer progression.Cell Mol Life Sci202539833630PubTator, text miningPubMed
Exploring novel drug targets for erectile dysfunction through plasma proteome with genome.Sex Med202439790564PubTator, text miningPubMed
Mapping the global interactome of the ARF family reveals spatial organization in cellular signaling pathways.J Cell Sci202438606629PubTator, text miningPubMed
Epigenetics of prenatal stress in humans: the current research landscape.Clin Epigenetics202438308342PubTator, text miningPubMed
Sox9 regulates alternative splicing and pancreatic beta cell function.Nat Commun202438238288PubTator, text miningPubMed

1 to 10 of 218

See all 218 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/379

GET https://conductscience.org/api/genes/v1/379/patents