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KDR: kinase insert domain receptor

1 protein, 432 patents, 84 drugs, 4,298 trials, 15,010 NIH grants and 53,720 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolKDRHGNC
Namekinase insert domain receptorHGNC
NCBI Gene ID3791NCBI Gene
HGNC IDHGNC:6307HGNC
EnsemblENSG00000128052NCBI Gene
AliasesCD309, FLK1, VEGFR, VEGFR2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P35968Vascular endothelial growth factor receptor 21,35654Ensembl, GeneID, HGNCUniProt

Patents 432

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4830719 A22026-10-2821P35968Espacenet
WO 2026190350 A12026-09-17260P35968Espacenet
JP 2026120541 A2026-07-2245P35968Espacenet
JP 2026090361 A2026-06-0221P35968Espacenet
JP 2026082857 A2026-05-1945P35968Espacenet
EP 4705273 A22026-03-11229P35968Espacenet
EP 4671279 A22025-12-3134P35968Espacenet
WO 2025257394 A12025-12-18344P35968Espacenet
WO 2025259718 A22025-12-1841P35968Espacenet
US 12479920 B22025-11-2534P35968Espacenet

Drugs 84

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
4SC-203CHEMBL5314406Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
AEE-788CHEMBL587723Vascular endothelial growth factor receptor 2 inhibitorINHIBITORChEMBL
AG-13958CHEMBL3545335Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
ALACIZUMAB PEGOLCHEMBL1742983Vascular endothelial growth factor receptor 2 antagonistANTAGONISTChEMBL
ALTIRATINIBCHEMBL3545365Vascular endothelial growth factor receptor 2 inhibitorINHIBITORChEMBL
AXITINIBCHEMBL1289926Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
BFH-772CHEMBL4080062Vascular endothelial growth factor receptor 2 inhibitorINHIBITORChEMBL
BMS-690514CHEMBL3545396Vascular endothelial growth factor receptor inhibitorINHIBITORChEMBL
BMS-794833CHEMBL2143592Vascular endothelial growth factor receptor 2 inhibitorINHIBITORChEMBL
BMS-817378CHEMBL3545050Vascular endothelial growth factor receptor 2 inhibitorINHIBITORChEMBL

Trials 4298

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07602101CATEQUENTINIBPHASE2ClinicalTrials.gov
NCT07594548RAMUCIRUMABPHASE1ClinicalTrials.gov
NCT07594015LENVATINIBPHASE2ClinicalTrials.gov
NCT07593040LENVATINIBPHASE2ClinicalTrials.gov
NCT07591597FRUQUINTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07589244RIVOCERANIBPHASE2/PHASE3ClinicalTrials.gov
NCT07583589NINTEDANIBPHASE2ClinicalTrials.gov
NCT07581821CATEQUENTINIBPHASE2ClinicalTrials.gov
NCT07572695SORAFENIBClinicalTrials.gov
NCT07572695MIDOSTAURINClinicalTrials.gov

NIH grants 15010

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant4392,025NIH's project files
P30CA008748Cancer Center Support Grant3422,025NIH's project files
P30CA006973Regional Oncology Research Center782,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support622,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award622,025NIH's project files
P50CA101942DF/HCC Kidney Cancer SPORE (supplement)582,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase542,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant532,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant532,025NIH's project files
P30CA016058Cancer Center Support Grant432,025NIH's project files

Papers 53720

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826627PubTator, text miningPubMed
42825359PubTator, text miningPubMed
42824982PubTator, text miningPubMed
42823708PubTator, text miningPubMed
42816033PubTator, text miningPubMed
42813850PubTator, text miningPubMed
42812292PubTator, text miningPubMed
42811645PubTator, text miningPubMed
42810841PubTator, text miningPubMed
42807652PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license