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Gene · 3799

KIF5B: kinesin family member 5B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KIF5B: kinesin family member 5B. Genes, record 3799. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3799

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Gene

Symbol
KIF5B
HGNC
Name
kinesin family member 5B
HGNC
NCBI Gene ID
3799
NCBI Gene
HGNC ID
HGNC:6324
HGNC
Ensembl
ENSG00000170759
NCBI Gene
Aliases
HEL-S-61, KDII, KINH, KNS, KNS1, UKHC, uKHC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P33176Kinesin-1 heavy chain96329Ensembl, GeneID, HGNC

Source UniProt

Patents56

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450889P33176Espacenet
EP 4650780 A22025-11-194468P33176Espacenet
EP 4641201 A22025-10-294014P33176Espacenet
JP 2025517969 A2025-06-124014P33176Espacenet
JP 2025517970 A2025-06-124468P33176Espacenet
US 11860162 B22024-01-021500P33176Espacenet
US 11694765 B22023-07-04188P33176Espacenet
US 11694765 B22023-07-04398P33176Espacenet
US 11633402 B22023-04-2530P33176Espacenet
US 11446398 B22022-09-2044334P33176Espacenet

1 to 10 of 56

See all 56 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PRALSETINIBCHEMBL4582651Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET inhibitorINHIBITORChEMBL
SELPERCATINIBCHEMBL4559134Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET inhibitorINHIBITORChEMBL

Trials28

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07418879PRALSETINIBClinicalTrials.gov
NCT07146893SELPERCATINIBEARLY_PHASE1ClinicalTrials.gov
NCT06563999PRALSETINIBPHASE2ClinicalTrials.gov
NCT06532149SELPERCATINIBClinicalTrials.gov
NCT06482086PRALSETINIBPHASE2ClinicalTrials.gov
NCT06458036SELPERCATINIBPHASE2ClinicalTrials.gov
NCT05668962SELPERCATINIBPHASE2ClinicalTrials.gov
NCT05364645SELPERCATINIBPHASE2ClinicalTrials.gov
NCT04819100SELPERCATINIBPHASE3ClinicalTrials.gov
NCT04760288PRALSETINIBPHASE3ClinicalTrials.gov

1 to 10 of 28

See all 28 trials

NIH grants1,449

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKIF5B papersNewest fiscal year
P30CA008748Cancer Center Support Grant412025
P30CA016672Cancer Center Support Grant332025
ZIAHD001607Protein Trafficking In The Endosomal-Lysosomal System122025
P30CA046934University of Colorado Cancer Center Support Grant112025
ZIANS003029Mitochondrial transport and energy metabolism in synaptic transmission and neuronal degeneration and regeneration102025
P30CA010815Consolidated Basic Cancer Research Program82025
R01CA251591Predicting sensitivity and resistance in RET-driven cancers82025
ZIANS002946Axonal transport of endolysosomal organelles and presynaptic cargos for the maintenance of axon cellular homeostasis and presynaptic function82025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center72025
P30CA068485Cancer Center Support Grant72025

1 to 10 of 1,449Source NIH's project files

See all 1,449 nih grants

Papers2,390

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A TRAK2-KIF5B complex mediates microtubule-based LDL vesicle transport during endothelial transcytosis.J Lipid Res202642767506PubTator, text miningPubMed
Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation.Science202642691184PubTator, text miningPubMed
De Novo Actionable Genomic Alterations in High-Grade Pulmonary Neuroendocrine Carcinomas: Therapeutic Implications of Targeted Treatment.Med Sci (Basel)202642646625PubTator, text miningPubMed
Bile extracellular vesicles for early cholangiocarcinoma detection in primary sclerosing cholangitis.JHEP Rep202642628796PubTator, text miningPubMed
Development and Characterization of a Patient-Derived KIF5B-RET Fusion Lung Adenocarcinoma Cell Line for Subcutaneous and Central Nervous System Tumor Models in Immunodeficient Mice.JTO Clin Res Rep202642568736PubTator, text miningPubMed
Insights into how JIP3 and JIP4 adaptor proteins relieve the auto-inhibited form of the kinesin-1 motor.J Biol Chem202642486258PubTator, text miningPubMed
TWEAK/FN14 inhibition synergizes with oncogene-directed tyrosine kinase inhibitors to overcome resistance across multiple driver contexts.Sci Rep202642399307PubTator, text miningPubMed
Case Report: KIF5B-ALK-rearranged renal cell carcinoma.Front Oncol202642376664PubTator, text miningPubMed
Metformin Activates AMP-Activated Protein Kinase-Transcription Factor EB Signaling to Restore Lysosomal and Mitochondrial Homeostasis and Suppress Epithelial-to-Mesenchymal Transition in Oxidative Stress-Injured Retinal Pigment Epithelium.
Am J Pathol202642276413PubTator, text miningPubMed
An engineered streptavidin condensate platform for chemically inducible control of endogenous proteins in mammalian cells.bioRxiv202642244538PubTator, text miningPubMed

1 to 10 of 2,390

See all 2,390 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3799

GET https://conductscience.org/api/genes/v1/3799/patents?page=2