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Gene · 38

ACAT1: acetyl-CoA acetyltransferase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACAT1: acetyl-CoA acetyltransferase 1. Genes, record 38. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/38

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Gene

Symbol
ACAT1
HGNC
Name
acetyl-CoA acetyltransferase 1
HGNC
NCBI Gene ID
38
NCBI Gene
HGNC ID
HGNC:93
HGNC
Ensembl
ENSG00000075239
NCBI Gene
Aliases
ACAT, MAT, T2, THIL
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P24752Acetyl-CoA acetyltransferase, mitochondrial4277Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21151P24752Espacenet
JP 2026004568 A2026-01-1436000P24752Espacenet
EP 4650780 A22025-11-192530P24752Espacenet
EP 4620519 A22025-09-2418P24752Espacenet
EP 4620520 A22025-09-2418P24752Espacenet
EP 4620521 A22025-09-2418P24752Espacenet
JP 2025517970 A2025-06-122530P24752Espacenet
JP 2025062604 A2025-04-141234P24752Espacenet
US 11860162 B22024-01-021427P24752Espacenet
JP 2023521663 A2023-05-25150P24752Espacenet

1 to 10 of 48

See all 48 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,504

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACAT1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
P30CA016672Cancer Center Support Grant62025
P30CA023168Cancer Center Support Grant62025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
R35CA231991Chemical Proteomic Platforms for Radically Expanding Cancer Druggability42025
P20GM113132The Institute for Biomolecular Targeting32025
P30DK026743UCSF Liver Center32025
R01CA140515Signaling importance of ‘functionless’ lyso-PAF, an inactive form of platelet activating factor, in melanoma with mutant Nras32025
I01BX002867Mechanisms Underlying Role of Intestinal P-glycoprotein in Inflammatory Bowel Disease22025
P01AG026572Perimenopause in Brain Aging and Alzheimer's Disease22025

1 to 10 of 1,504Source NIH's project files

See all 1,504 nih grants

Papers2,780

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
ACAT1-Mediated SP1-K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD.Adv Sci (Weinh)202642801550PubTator, text miningPubMed
Ketone metabolism defects in childhood: a spectrum of overlapping presentations and clinical features.J Pediatr Endocrinol Metab202642741830PubTator, text miningPubMed
Multi-Omics Integration Identifies a Five-Gene Metabolic Signature With Experimental Validation in Clear Cell Renal Cell Carcinoma.Cancer Rep (Hoboken)202642702836PubTator, text miningPubMed
Cholesterol metabolism dysregulation in eyelid sebaceous gland carcinoma and its clinical significance.Indian J Ophthalmol202642671098PubTator, text miningPubMed
Longitudinal biochemical profiles in beta-ketothiolase deficiency: Phase-dependent diagnostic challenges and metabolic variability.Mol Genet Metab202642659719PubTator, text miningPubMed
Beta-ketothiolase deficiency: two novel ACAT1 variants and a retrospective study of 76 cases in China.Mol Genet Metab202642641357PubTator, text miningPubMed
Genetic associations and candidate functional genes linking depression and obesity: a multi-omics integrative study.Front Genet202642626419PubTator, text miningPubMed
Crotonylation of ACAT1 K181 contributes to radioresistance by impacting lactate metabolism.Commun Biol202642587030PubTator, text miningPubMed
Elucidation of ACAT1's role in hepatic ischemia-reperfusion injury: TFEB-mediated mitophagy and ferroptosis modulation as therapeutic targets.J Pharm Anal202642434332PubTator, text miningPubMed
Single-Cell Transcriptomic and Metabolic Signatures in Exhausted and Classical Memory B Cells-An Exploratory Analysis in Systemic Lupus Erythematosus and Lupus Nephritis.Biomedicines202642351616PubTator, text miningPubMed

1 to 10 of 2,780

See all 2,780 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/38

GET https://conductscience.org/api/genes/v1/38/patents?page=2