Gene · 38
ACAT1: acetyl-CoA acetyltransferase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ACAT1: acetyl-CoA acetyltransferase 1. Genes, record 38. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/38
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P24752 | Acetyl-CoA acetyltransferase, mitochondrial | 427 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents48
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 151 | P24752 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 36000 | P24752 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2530 | P24752 | Espacenet |
| EP 4620519 A2 | 2025-09-24 | 18 | P24752 | Espacenet |
| EP 4620520 A2 | 2025-09-24 | 18 | P24752 | Espacenet |
| EP 4620521 A2 | 2025-09-24 | 18 | P24752 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2530 | P24752 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 1234 | P24752 | Espacenet |
| US 11860162 B2 | 2024-01-02 | 1427 | P24752 | Espacenet |
| JP 2023521663 A | 2023-05-25 | 150 | P24752 | Espacenet |
1 to 10 of 48
See all 48 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,504
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ACAT1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P30CA023168 | Cancer Center Support Grant | 6 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 4 | 2025 |
| R35CA231991 | Chemical Proteomic Platforms for Radically Expanding Cancer Druggability | 4 | 2025 |
| P20GM113132 | The Institute for Biomolecular Targeting | 3 | 2025 |
| P30DK026743 | UCSF Liver Center | 3 | 2025 |
| R01CA140515 | Signaling importance of ‘functionless’ lyso-PAF, an inactive form of platelet activating factor, in melanoma with mutant Nras | 3 | 2025 |
| I01BX002867 | Mechanisms Underlying Role of Intestinal P-glycoprotein in Inflammatory Bowel Disease | 2 | 2025 |
| P01AG026572 | Perimenopause in Brain Aging and Alzheimer's Disease | 2 | 2025 |
1 to 10 of 1,504Source NIH's project files
See all 1,504 nih grantsPapers2,780
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| ACAT1-Mediated SP1-K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD. | Adv Sci (Weinh) | 2026 | 42801550 | PubTator, text mining | PubMed |
| Ketone metabolism defects in childhood: a spectrum of overlapping presentations and clinical features. | J Pediatr Endocrinol Metab | 2026 | 42741830 | PubTator, text mining | PubMed |
| Multi-Omics Integration Identifies a Five-Gene Metabolic Signature With Experimental Validation in Clear Cell Renal Cell Carcinoma. | Cancer Rep (Hoboken) | 2026 | 42702836 | PubTator, text mining | PubMed |
| Cholesterol metabolism dysregulation in eyelid sebaceous gland carcinoma and its clinical significance. | Indian J Ophthalmol | 2026 | 42671098 | PubTator, text mining | PubMed |
| Longitudinal biochemical profiles in beta-ketothiolase deficiency: Phase-dependent diagnostic challenges and metabolic variability. | Mol Genet Metab | 2026 | 42659719 | PubTator, text mining | PubMed |
| Beta-ketothiolase deficiency: two novel ACAT1 variants and a retrospective study of 76 cases in China. | Mol Genet Metab | 2026 | 42641357 | PubTator, text mining | PubMed |
| Genetic associations and candidate functional genes linking depression and obesity: a multi-omics integrative study. | Front Genet | 2026 | 42626419 | PubTator, text mining | PubMed |
| Crotonylation of ACAT1 K181 contributes to radioresistance by impacting lactate metabolism. | Commun Biol | 2026 | 42587030 | PubTator, text mining | PubMed |
| Elucidation of ACAT1's role in hepatic ischemia-reperfusion injury: TFEB-mediated mitophagy and ferroptosis modulation as therapeutic targets. | J Pharm Anal | 2026 | 42434332 | PubTator, text mining | PubMed |
| Single-Cell Transcriptomic and Metabolic Signatures in Exhausted and Classical Memory B Cells-An Exploratory Analysis in Systemic Lupus Erythematosus and Lupus Nephritis. | Biomedicines | 2026 | 42351616 | PubTator, text mining | PubMed |
1 to 10 of 2,780
See all 2,780 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/38
GET https://conductscience.org/api/genes/v1/38/patents?page=2