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Gene · 3802

KIR2DL1: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KIR2DL1: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1. Genes, record 3802. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3802

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Gene

Symbol
KIR2DL1
HGNC
Name
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
HGNC
NCBI Gene ID
3802
NCBI Gene
HGNC ID
HGNC:6329
HGNC
Ensembl
ENSG00000125498
NCBI Gene
Aliases
47.11, CD158A, KIR-K64, KIR221, NKAT, NKAT-1, NKAT1, cl-42, nkat1, p58.1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P43626Killer cell immunoglobulin-like receptor 2DL13484Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450749P43626Espacenet
EP 4650780 A22025-11-196220P43626Espacenet
JP 2025517970 A2025-06-126220P43626Espacenet
US 11453908 B22022-09-2760P43626Espacenet
US 11446398 B22022-09-2043828P43626Espacenet
US 11446398 B22022-09-2043829P43626Espacenet
US 11446398 B22022-09-2043830P43626Espacenet
US 11446398 B22022-09-2043831P43626Espacenet
US 11446398 B22022-09-2043834P43626Espacenet
US 11446398 B22022-09-2043835P43626Espacenet

1 to 10 of 42

See all 42 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
IPH-2101CHEMBL2109498Killer cell immunoglobulin-like receptor 2DL1 inhibitorINHIBITORChEMBL
LIRILUMABCHEMBL2109500Killer cell immunoglobulin-like receptor 2DL1 inhibitorINHIBITORChEMBL

Trials14

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03347123LIRILUMABPHASE1/PHASE22022-02-28ClinicalTrials.gov
NCT03341936LIRILUMABPHASE22022-06-16ClinicalTrials.gov
NCT02813135LIRILUMABPHASE1/PHASE2ClinicalTrials.gov
NCT02599649LIRILUMABPHASE22020-01-06ClinicalTrials.gov
NCT02481297LIRILUMABPHASE22020-05-26ClinicalTrials.gov
NCT02399917LIRILUMABPHASE22019-09-24ClinicalTrials.gov
NCT02252263LIRILUMABPHASE1ClinicalTrials.gov
NCT01687387LIRILUMABPHASE22019-02-08ClinicalTrials.gov
NCT01592370LIRILUMABPHASE1/PHASE22022-02-17ClinicalTrials.gov
NCT01256073IPH-2101PHASE1ClinicalTrials.gov

1 to 10 of 14

See all 14 trials

NIH grants1,023

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKIR2DL1 papersNewest fiscal year
P01CA111412NK cells, their receptors and cancer therapy362025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies232025
T32AI007290Molecular and Cellular Immunobiology232025
U01AI090905Insights Into Immune-Related Diseases Born from Population Genomics232025
P30CA008748Cancer Center Support Grant172025
P30CA016672Cancer Center Support Grant162025
P30CA021765Cancer Center Support Grant (CCSG)162025
P30CA077598Cancer Center Support Grant162025
U01AI069197Hematopoietic Stem Cell And Cord Blood Transplantation152025
ZIABC010791Effects of genetic polymorphism in MHC, KIR, and related loci on human disease152025

1 to 10 of 1,023Source NIH's project files

See all 1,023 nih grants

Papers2,190

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Characterisation of the Novel KIR2DL1*070 Allele Identified in a Chinese Han Individual.HLA202642813291PubTator, text miningPubMed
Innate immune imprints shape HIV-1 reservoir cell persistence during long-term antiretroviral therapy.Nat Immunol202642680897PubTator, text miningPubMed
Natural Killer Cell Phenotypic Changes and Activating Receptor Loss Posttrauma.Ann Surg202642572148PubTator, text miningPubMed
Flow Cytometric Detection of NK Cell KIR Receptors: a Novel Tool for Functional Profiling in Reproductive Failure.Clin Lab202642411671PubTator, text miningPubMed
Using peptide-exchange systems to interrogate peptide-specific KIR binding to HLA Class I.Discov Immunol202642293769PubTator, text miningPubMed
Altered NK cell receptor profiles and immune-inflammatory markers in adolescent major depressive disorder: associations with cognitive impairment.BMC Psychiatry202642143288PubTator, text miningPubMed
The Identification of Novel KIR3DL1 and KIR2DL1 Alleles in Individuals From India.HLA202641823565PubTator, text miningPubMed
Integrative Roles of NK Receptors and γδ TCRs in γδ T Cell-Mediated Cancer Immunity.Immune Netw202641800030PubTator, text miningPubMed
Mechanisms of tumor cell evasion from NK cell-mediated killing and advances in NK cell-based cancer immunotherapy.Pharm Sci Adv202641799416PubTator, text miningPubMed
Predicting skin melanoma progression via LAG-3, TIGIT and HAVCR2.Funct Integr Genomics202641746432PubTator, text miningPubMed

1 to 10 of 2,190

See all 2,190 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3802

GET https://conductscience.org/api/genes/v1/3802/patents?page=2