Gene · 3802
KIR2DL1: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KIR2DL1: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1. Genes, record 3802. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3802
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P43626 | Killer cell immunoglobulin-like receptor 2DL1 | 348 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents42
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 50749 | P43626 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6220 | P43626 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6220 | P43626 | Espacenet |
| US 11453908 B2 | 2022-09-27 | 60 | P43626 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 43828 | P43626 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 43829 | P43626 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 43830 | P43626 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 43831 | P43626 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 43834 | P43626 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 43835 | P43626 | Espacenet |
1 to 10 of 42
See all 42 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials14
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT03347123 | LIRILUMAB | PHASE1/PHASE2 | 2022-02-28 | ClinicalTrials.gov |
| NCT03341936 | LIRILUMAB | PHASE2 | 2022-06-16 | ClinicalTrials.gov |
| NCT02813135 | LIRILUMAB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT02599649 | LIRILUMAB | PHASE2 | 2020-01-06 | ClinicalTrials.gov |
| NCT02481297 | LIRILUMAB | PHASE2 | 2020-05-26 | ClinicalTrials.gov |
| NCT02399917 | LIRILUMAB | PHASE2 | 2019-09-24 | ClinicalTrials.gov |
| NCT02252263 | LIRILUMAB | PHASE1 | ClinicalTrials.gov | |
| NCT01687387 | LIRILUMAB | PHASE2 | 2019-02-08 | ClinicalTrials.gov |
| NCT01592370 | LIRILUMAB | PHASE1/PHASE2 | 2022-02-17 | ClinicalTrials.gov |
| NCT01256073 | IPH-2101 | PHASE1 | ClinicalTrials.gov |
1 to 10 of 14
See all 14 trialsNIH grants1,023
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KIR2DL1 papers | Newest fiscal year |
|---|---|---|---|
| P01CA111412 | NK cells, their receptors and cancer therapy | 36 | 2025 |
| P01CA065493 | Off-the-Shelf Immune Effector Cells for Hematological Malignancies | 23 | 2025 |
| T32AI007290 | Molecular and Cellular Immunobiology | 23 | 2025 |
| U01AI090905 | Insights Into Immune-Related Diseases Born from Population Genomics | 23 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 17 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 16 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 16 | 2025 |
| P30CA077598 | Cancer Center Support Grant | 16 | 2025 |
| U01AI069197 | Hematopoietic Stem Cell And Cord Blood Transplantation | 15 | 2025 |
| ZIABC010791 | Effects of genetic polymorphism in MHC, KIR, and related loci on human disease | 15 | 2025 |
1 to 10 of 1,023Source NIH's project files
See all 1,023 nih grantsPapers2,190
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Characterisation of the Novel KIR2DL1*070 Allele Identified in a Chinese Han Individual. | HLA | 2026 | 42813291 | PubTator, text mining | PubMed |
| Innate immune imprints shape HIV-1 reservoir cell persistence during long-term antiretroviral therapy. | Nat Immunol | 2026 | 42680897 | PubTator, text mining | PubMed |
| Natural Killer Cell Phenotypic Changes and Activating Receptor Loss Posttrauma. | Ann Surg | 2026 | 42572148 | PubTator, text mining | PubMed |
| Flow Cytometric Detection of NK Cell KIR Receptors: a Novel Tool for Functional Profiling in Reproductive Failure. | Clin Lab | 2026 | 42411671 | PubTator, text mining | PubMed |
| Using peptide-exchange systems to interrogate peptide-specific KIR binding to HLA Class I. | Discov Immunol | 2026 | 42293769 | PubTator, text mining | PubMed |
| Altered NK cell receptor profiles and immune-inflammatory markers in adolescent major depressive disorder: associations with cognitive impairment. | BMC Psychiatry | 2026 | 42143288 | PubTator, text mining | PubMed |
| The Identification of Novel KIR3DL1 and KIR2DL1 Alleles in Individuals From India. | HLA | 2026 | 41823565 | PubTator, text mining | PubMed |
| Integrative Roles of NK Receptors and γδ TCRs in γδ T Cell-Mediated Cancer Immunity. | Immune Netw | 2026 | 41800030 | PubTator, text mining | PubMed |
| Mechanisms of tumor cell evasion from NK cell-mediated killing and advances in NK cell-based cancer immunotherapy. | Pharm Sci Adv | 2026 | 41799416 | PubTator, text mining | PubMed |
| Predicting skin melanoma progression via LAG-3, TIGIT and HAVCR2. | Funct Integr Genomics | 2026 | 41746432 | PubTator, text mining | PubMed |
1 to 10 of 2,190
See all 2,190 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3802
GET https://conductscience.org/api/genes/v1/3802/patents?page=2