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Gene · 3803

KIR2DL2: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KIR2DL2: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2. Genes, record 3803. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3803

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Gene

Symbol
KIR2DL2
HGNC
Name
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2
HGNC
NCBI Gene ID
3803
NCBI Gene
HGNC ID
HGNC:6330
HGNC
Aliases
CD158B1, CD158b, CD158k, NKAT-6, NKAT6, cl-43, nkat6, p58.2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P43627Killer cell immunoglobulin-like receptor 2DL234810GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 11446398 B22022-09-2043864P43627Espacenet
US 11446398 B22022-09-2043870P43627Espacenet
US 11446398 B22022-09-2043871P43627Espacenet
US 11446398 B22022-09-2043873P43627Espacenet
US 11446398 B22022-09-2043875P43627Espacenet
US 11446398 B22022-09-2043877P43627Espacenet
JP 2022524081 A2022-04-27146835P43627Espacenet
JP 2022524081 A2022-04-27146841P43627Espacenet
JP 2022524081 A2022-04-27146842P43627Espacenet
JP 2022524081 A2022-04-27146844P43627Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants873

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKIR2DL2 papersNewest fiscal year
P01CA111412NK cells, their receptors and cancer therapy252025
P30CA008748Cancer Center Support Grant202025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies172025
U01AI090905Insights Into Immune-Related Diseases Born from Population Genomics172025
ZIABC010791Effects of genetic polymorphism in MHC, KIR, and related loci on human disease162025
U01AI069197Hematopoietic Stem Cell And Cord Blood Transplantation152025
T32AI007290Molecular and Cellular Immunobiology142025
P30CA077598Cancer Center Support Grant112025
R01AI128775Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic Data112025
P30CA021765Cancer Center Support Grant (CCSG)102025

1 to 10 of 873Source NIH's project files

See all 873 nih grants

Papers1,698

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Defective IL-17 production is associated with reduced IL-1β levels in response to Mycobacterium tuberculosis in HIV+ children with latent tuberculosis infection.Front Immunol202642780500PubTator, text miningPubMed
Natural Killer Cell Phenotypic Changes and Activating Receptor Loss Posttrauma.Ann Surg202642572148PubTator, text miningPubMed
Inhibitory HLA-C/KIR2DL2 Interactions and KIR Allelic Polymorphisms Are Associated With Susceptibility to Philadelphia Chromosome-Negative Myeloproliferative Neoplasms.EJHaem202642421796PubTator, text miningPubMed
Abnormal expression of ILT2, NKG2D and NKp46 receptors on natural killer cells in women with unexplained recurrent implantation failure.J Reprod Immunol202641950815PubTator, text miningPubMed
Allogeneic CD56+ cell-based immunotherapy in a patient with Fanconi anemia developing acute myeloid leukemia.J Cancer Res Clin Oncol202641920213PubTator, text miningPubMed
Multiblock proteomic profiling identifies novel biomarkers linking prediabetes with preclinical atherosclerosis in apparently healthy adults.Cardiovasc Diabetol202641904484PubTator, text miningPubMed
Integrative Roles of NK Receptors and γδ TCRs in γδ T Cell-Mediated Cancer Immunity.Immune Netw202641800030PubTator, text miningPubMed
Mechanisms of tumor cell evasion from NK cell-mediated killing and advances in NK cell-based cancer immunotherapy.Pharm Sci Adv202641799416PubTator, text miningPubMed
Development and evaluation of an inhalable nanoemulsion system for enhancing NK cell function against osteosarcoma pulmonary metastases.Front Immunol202641766883PubTator, text miningPubMed
Feeder-free ex vivo expansion of cord blood-derived natural killer cells for enhanced proliferation and functional maturation.Sci Rep202641735442PubTator, text miningPubMed

1 to 10 of 1,698

See all 1,698 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3803

GET https://conductscience.org/api/genes/v1/3803/patents?page=2