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Gene · 3804

KIR2DL3: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KIR2DL3: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3. Genes, record 3804. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3804

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Gene

Symbol
KIR2DL3
HGNC
Name
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3
HGNC
NCBI Gene ID
3804
NCBI Gene
HGNC ID
HGNC:6331
HGNC
Ensembl
ENSG00000243772
NCBI Gene
Aliases
CD158B2, CD158b, GL183, KIR-023GB, KIR-K7b, KIR-K7c, KIR2DL, KIRCL23, NKAT, NKAT-2, NKAT2, NKAT2A, NKAT2B, cl-6, nkat2, nkat2a, nkat2b, p58
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P43628Killer cell immunoglobulin-like receptor 2DL33413Ensembl, GeneID, HGNC

Source UniProt

Patents84

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450750P43628Espacenet
EP 4650780 A22025-11-196722P43628Espacenet
JP 2025529142 A2025-09-042298P43628Espacenet
US 12371689 B22025-07-292298P43628Espacenet
JP 2025517970 A2025-06-126722P43628Espacenet
JP 2025081298 A2025-05-27345P43628Espacenet
KR 1020250067191 A2025-05-14345P43628Espacenet
US 11981731 B22024-05-14345P43628Espacenet
US 11919946 B22024-03-0555P43628Espacenet
KR 1020230149327 A2023-10-26345P43628Espacenet

1 to 10 of 84

See all 84 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
IPH-2101CHEMBL2109498Killer cell immunoglobulin-like receptor 2DL3 inhibitorINHIBITORChEMBL
LIRILUMABCHEMBL2109500Killer cell immunoglobulin-like receptor 2DL3 inhibitorINHIBITORChEMBL

Trials14

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03347123LIRILUMABPHASE1/PHASE22022-02-28ClinicalTrials.gov
NCT03341936LIRILUMABPHASE22022-06-16ClinicalTrials.gov
NCT02813135LIRILUMABPHASE1/PHASE2ClinicalTrials.gov
NCT02599649LIRILUMABPHASE22020-01-06ClinicalTrials.gov
NCT02481297LIRILUMABPHASE22020-05-26ClinicalTrials.gov
NCT02399917LIRILUMABPHASE22019-09-24ClinicalTrials.gov
NCT02252263LIRILUMABPHASE1ClinicalTrials.gov
NCT01687387LIRILUMABPHASE22019-02-08ClinicalTrials.gov
NCT01592370LIRILUMABPHASE1/PHASE22022-02-17ClinicalTrials.gov
NCT01256073IPH-2101PHASE1ClinicalTrials.gov

1 to 10 of 14

See all 14 trials

NIH grants1,324

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKIR2DL3 papersNewest fiscal year
P30CA008748Cancer Center Support Grant252025
T32AI007290Molecular and Cellular Immunobiology232025
P01CA111412NK cells, their receptors and cancer therapy212025
U01AI090905Insights Into Immune-Related Diseases Born from Population Genomics172025
ZIABC010791Effects of genetic polymorphism in MHC, KIR, and related loci on human disease152025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies142025
U01AI069197Hematopoietic Stem Cell And Cord Blood Transplantation122025
R01AI128775Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic Data102025
P30CA077598Cancer Center Support Grant92025
ZIABC010792Molecular genetics and population studies of the KIR and HLA gene complexes92025

1 to 10 of 1,324Source NIH's project files

See all 1,324 nih grants

Papers2,392

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Prognostic value and immune landscape implications of using a novel homologous recombination repair pathway signature in prostate cancer: A retrospective cohort study.J Int Med Res202642754412PubTator, text miningPubMed
Computational Analysis of Endothelial Cell-related Genes in Ovarian Cancer and Preliminary in vitro Validation of COL1A1.Curr Med Chem202642517396PubTator, text miningPubMed
Flow Cytometric Detection of NK Cell KIR Receptors: a Novel Tool for Functional Profiling in Reproductive Failure.Clin Lab202642411671PubTator, text miningPubMed
Integrative Analysis Reveals BPTF, COL1A1, and COL4A2 as Fibroblast-Related Biomarkers Associated with Immune Infiltration in Ovarian Cancer.Curr Med Chem202642381315PubTator, text miningPubMed
Emphysema Shapes a Pro-Inflammatory Immune Microenvironment in Pulmonary Adenocarcinoma: A Pilot Immune Transcriptomic Profiling Study.Int J Mol Sci202642123542PubTator, text miningPubMed
Functional heterogeneity of γδ T cells in colorectal cancer.Front Immunol202641953027PubTator, text miningPubMed
Transcriptomic Determinants of Circulating Immunity Predict Immune-Related Adverse Events (irAEs) in Cancer Patients Receiving PD-1/PD-L1 Blockade.Thorac Cancer202641920053PubTator, text miningPubMed
Multi‑omics and their integration in psoriasis research (Review).Mol Med Rep202641891974PubTator, text miningPubMed
Molecular signatures and causal factors underlying latent cytomegalovirus infection among people living with HIV (PLHIV).Nat Commun202641881997PubTator, text miningPubMed
Dynamic Allostery in T Cell Receptor Specificity: A Role for Peptides and MHC Polymorphisms in Allosterically Tuning Immune Recognition.Bioessays202641879488PubTator, text miningPubMed

1 to 10 of 2,392

See all 2,392 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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