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Gene · 3812

KIR3DL2: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KIR3DL2: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2. Genes, record 3812. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3812

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Gene

Symbol
KIR3DL2
HGNC
Name
killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2
HGNC
NCBI Gene ID
3812
NCBI Gene
HGNC ID
HGNC:6339
HGNC
Ensembl
ENSG00000240403
NCBI Gene
Aliases
3DL2, CD158K, KIR-3DL2, NKAT-4, NKAT4, NKAT4B, cl-5, nkat4, nkat4a, nkat4b, p140
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P43630Killer cell immunoglobulin-like receptor 3DL24550Ensembl, GeneID, HGNC

Source UniProt

Patents62

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450738P43630Espacenet
EP 4650780 A22025-11-195612P43630Espacenet
JP 2025529142 A2025-09-042301P43630Espacenet
US 12371689 B22025-07-292301P43630Espacenet
JP 2025517970 A2025-06-125612P43630Espacenet
US 12084498 B22024-09-1027P43630Espacenet
US 11858990 B22024-01-02160P43630Espacenet
JP 2023525049 A2023-06-14273P43630Espacenet
KR 1020230010228 A2023-01-18273P43630Espacenet
US 11446398 B22022-09-2043694P43630Espacenet

1 to 10 of 62

See all 62 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
LACUTAMABCHEMBL4297998Killer cell immunoglobulin-like receptor 3DL2 antagonistANTAGONIST

Source ChEMBL

Trials4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05321147LACUTAMABPHASE1ClinicalTrials.gov
NCT04984837LACUTAMABPHASE2ClinicalTrials.gov
NCT03902184LACUTAMABPHASE2ClinicalTrials.gov
NCT02593045LACUTAMABPHASE1ClinicalTrials.gov

NIH grants1,158

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKIR3DL2 papersNewest fiscal year
P01CA111412NK cells, their receptors and cancer therapy302025
U01AI090905Insights Into Immune-Related Diseases Born from Population Genomics212025
R01AI128775Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic Data182025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies162025
ZIABC010792Molecular genetics and population studies of the KIR and HLA gene complexes152025
T32AI007290Molecular and Cellular Immunobiology142025
U24CA076518A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research142025
ZIABC010791Effects of genetic polymorphism in MHC, KIR, and related loci on human disease132025
P30CA008748Cancer Center Support Grant122025
P30CA021765Cancer Center Support Grant (CCSG)82025

1 to 10 of 1,158Source NIH's project files

See all 1,158 nih grants

Papers2,367

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A practical difference from the normal approach to evaluate natural killer (NK) cells and NK cell neoplasms by flow cytometry.Cytometry B Clin Cytom202642788374PubTator, text miningPubMed
Immune Dysregulation, Compartment-Specific Biology, and Therapeutic Biomarkers in Mycosis Fungoides and Sézary Syndrome.Cells202642738870PubTator, text miningPubMed
Contrasting relapse rate associated with the absence of HLA-A3/A11 in T cell-replete haploidentical transplantation.Front Immunol202642712389PubTator, text miningPubMed
A Six-year Response to Belinostat in a Highly Probable Case of Relapsed/Refractory MF/SS Initially Classified as PTCL-NOS: A Case Report.Onco Targets Ther202642621534PubTator, text miningPubMed
Dual-module aCAR-iCAR NK cells for solid tumors: cascade resistance mechanisms, AI-driven engineering, and precision stratification.Front Immunol202642582347PubTator, text miningPubMed
Single-cell immune landscape of patients with different ovarian reserves during COH.Funct Integr Genomics202642533238PubTator, text miningPubMed
Effects of donor killer-cell immunoglobulin-like receptor genotypes on clinical outcome after allogeneic hematopoietic stem cell transplantation-a systematic review and meta-analysis.Front Immunol202642523659PubTator, text miningPubMed
Graph-KIR: graph-based KIR copy number estimation and allele calling using short-read sequencing data.Bioinformatics202642478776PubTator, text miningPubMed
NK-like and networked CD8+ T cell immunity mediates exceptional HIV control.bioRxiv202642465352PubTator, text miningPubMed
Two-way tuning of the decidual natural killer cells and recurrent pregnancy loss.Sci Rep202642331945PubTator, text miningPubMed

1 to 10 of 2,367

See all 2,367 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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