Gene · 3812
KIR3DL2: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KIR3DL2: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2. Genes, record 3812. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3812
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P43630 | Killer cell immunoglobulin-like receptor 3DL2 | 455 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents62
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 50738 | P43630 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5612 | P43630 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2301 | P43630 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2301 | P43630 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5612 | P43630 | Espacenet |
| US 12084498 B2 | 2024-09-10 | 27 | P43630 | Espacenet |
| US 11858990 B2 | 2024-01-02 | 160 | P43630 | Espacenet |
| JP 2023525049 A | 2023-06-14 | 273 | P43630 | Espacenet |
| KR 1020230010228 A | 2023-01-18 | 273 | P43630 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 43694 | P43630 | Espacenet |
1 to 10 of 62
See all 62 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| LACUTAMAB | CHEMBL4297998 | Killer cell immunoglobulin-like receptor 3DL2 antagonist | ANTAGONIST |
Source ChEMBL
Trials4
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05321147 | LACUTAMAB | PHASE1 | ClinicalTrials.gov | |
| NCT04984837 | LACUTAMAB | PHASE2 | ClinicalTrials.gov | |
| NCT03902184 | LACUTAMAB | PHASE2 | ClinicalTrials.gov | |
| NCT02593045 | LACUTAMAB | PHASE1 | ClinicalTrials.gov |
NIH grants1,158
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KIR3DL2 papers | Newest fiscal year |
|---|---|---|---|
| P01CA111412 | NK cells, their receptors and cancer therapy | 30 | 2025 |
| U01AI090905 | Insights Into Immune-Related Diseases Born from Population Genomics | 21 | 2025 |
| R01AI128775 | Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic Data | 18 | 2025 |
| P01CA065493 | Off-the-Shelf Immune Effector Cells for Hematological Malignancies | 16 | 2025 |
| ZIABC010792 | Molecular genetics and population studies of the KIR and HLA gene complexes | 15 | 2025 |
| T32AI007290 | Molecular and Cellular Immunobiology | 14 | 2025 |
| U24CA076518 | A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research | 14 | 2025 |
| ZIABC010791 | Effects of genetic polymorphism in MHC, KIR, and related loci on human disease | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 8 | 2025 |
1 to 10 of 1,158Source NIH's project files
See all 1,158 nih grantsPapers2,367
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A practical difference from the normal approach to evaluate natural killer (NK) cells and NK cell neoplasms by flow cytometry. | Cytometry B Clin Cytom | 2026 | 42788374 | PubTator, text mining | PubMed |
| Immune Dysregulation, Compartment-Specific Biology, and Therapeutic Biomarkers in Mycosis Fungoides and Sézary Syndrome. | Cells | 2026 | 42738870 | PubTator, text mining | PubMed |
| Contrasting relapse rate associated with the absence of HLA-A3/A11 in T cell-replete haploidentical transplantation. | Front Immunol | 2026 | 42712389 | PubTator, text mining | PubMed |
| A Six-year Response to Belinostat in a Highly Probable Case of Relapsed/Refractory MF/SS Initially Classified as PTCL-NOS: A Case Report. | Onco Targets Ther | 2026 | 42621534 | PubTator, text mining | PubMed |
| Dual-module aCAR-iCAR NK cells for solid tumors: cascade resistance mechanisms, AI-driven engineering, and precision stratification. | Front Immunol | 2026 | 42582347 | PubTator, text mining | PubMed |
| Single-cell immune landscape of patients with different ovarian reserves during COH. | Funct Integr Genomics | 2026 | 42533238 | PubTator, text mining | PubMed |
| Effects of donor killer-cell immunoglobulin-like receptor genotypes on clinical outcome after allogeneic hematopoietic stem cell transplantation-a systematic review and meta-analysis. | Front Immunol | 2026 | 42523659 | PubTator, text mining | PubMed |
| Graph-KIR: graph-based KIR copy number estimation and allele calling using short-read sequencing data. | Bioinformatics | 2026 | 42478776 | PubTator, text mining | PubMed |
| NK-like and networked CD8+ T cell immunity mediates exceptional HIV control. | bioRxiv | 2026 | 42465352 | PubTator, text mining | PubMed |
| Two-way tuning of the decidual natural killer cells and recurrent pregnancy loss. | Sci Rep | 2026 | 42331945 | PubTator, text mining | PubMed |
1 to 10 of 2,367
See all 2,367 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3812
GET https://conductscience.org/api/genes/v1/3812/patents?page=2