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Gene · 3816

KLK1: kallikrein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KLK1: kallikrein 1. Genes, record 3816. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3816

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Gene

Symbol
KLK1
HGNC
Name
kallikrein 1
HGNC
NCBI Gene ID
3816
NCBI Gene
HGNC ID
HGNC:6357
HGNC
Ensembl
ENSG00000167748
NCBI Gene
Aliases
KLKR, Klk6, hK1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P06870Kallikrein-12622Ensembl, GeneID, HGNC

Source UniProt

Patents116

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4740938 A12026-05-131P06870Espacenet
JP 2026004568 A2026-01-1450530P06870Espacenet
EP 4650780 A22025-11-194075P06870Espacenet
JP 2025147176 A2025-10-067490P06870Espacenet
JP 2025529142 A2025-09-046819P06870Espacenet
US 12371689 B22025-07-296819P06870Espacenet
US 12329805 B22025-06-171P06870Espacenet
JP 2025517970 A2025-06-124075P06870Espacenet
JP 2025031832 A2025-03-071P06870Espacenet
JP 2025028160 A2025-02-287490P06870Espacenet

1 to 10 of 116

See all 116 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants585

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKLK1 papersNewest fiscal year
P30DK036836Diabetes Research Center42025
P30CA006973Regional Oncology Research Center32025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant32025
P50CA092629SPORE in Prostate Cancer32025
R01EY019309A new pathogenic mechanism for diabetic retinopathy32025
P30CA008748Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
P30DK034854Integrated Epithelial and Muscosal Biology22025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease22025
R01DK127082Balance between HNF4a isoforms in the carbohydrate-lipid metabolic switch22025

1 to 10 of 585Source NIH's project files

See all 585 nih grants

Papers1,486

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A cross-platform validated biomarker signature for mucoepidermoid carcinoma identified by integrated WGCNA and machine learning.Comput Biol Chem202642664892PubTator, text miningPubMed
Unveiling potential natural promoters of calcium oxalate kidney stones in the urine via anion-exchange chromatography, crystal assays, and proteomics.Mol Cell Biochem202642418121PubTator, text miningPubMed
Molecular-Genetic Basis of Pulmonary Arterial Hypertension (PAH).Curr Issues Mol Biol202642353577PubTator, text miningPubMed
Structural and functional characterization of human kallistatin.Biochem Biophys Rep202642282852PubTator, text miningPubMed
Kallikrein-8 contributes to kallikrein-kinin system dysregulation in Alzheimer's disease.Exp Neurol202642140379PubTator, text miningPubMed
Genome-Wide Discovery Reveals Adipose-Specific and Systemic Regulators of Insulin Resistance.medRxiv202641959785PubTator, text miningPubMed
Unveiling Colorectal Cancer Cell Heterogeneity: Identification of Biomarkers and Disease-driving Cell Subpopulations through Scissor and CIBERSORTx on Integrated Transcriptomic Profiling.Comput Biol Chem202641904900PubTator, text miningPubMed
Expanding the genetic burden of low-evidence genes in pulmonary arterial hypertension.Eur J Hum Genet202641882294PubTator, text miningPubMed
Endothelial triple-pathway vasorelaxation as an adjunctive strategy in resistant hypertension.J Hypertens202641860188PubTator, text miningPubMed
Alteplase and Angioedema: Can Clinical Exome Sequencing Redefine the Paradigm?Life (Basel)202641752838PubTator, text miningPubMed

1 to 10 of 1,486

See all 1,486 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3816

GET https://conductscience.org/api/genes/v1/3816/patents?page=2