ConductScience.org, home

Gene · 3818

KLKB1: kallikrein B1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. KLKB1: kallikrein B1. Genes, record 3818. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3818

On this page

Gene

Symbol
KLKB1
HGNC
Name
kallikrein B1
HGNC
NCBI Gene ID
3818
NCBI Gene
HGNC ID
HGNC:6371
HGNC
Ensembl
ENSG00000164344
NCBI Gene
Aliases
KLK3, PKK, PKKD, PPK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P03952Plasma kallikrein63822Ensembl, GeneID, HGNC

Source UniProt

Patents120

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026048915 A2026-03-173P03952Espacenet
JP 2026004568 A2026-01-1450532P03952Espacenet
EP 4650780 A22025-11-192384P03952Espacenet
US 12460016 B22025-11-042P03952Espacenet
EP 4640849 A22025-10-29283P03952Espacenet
EP 4641201 A22025-10-291960P03952Espacenet
JP 2025147176 A2025-10-067585P03952Espacenet
JP 2025519096 A2025-06-24283P03952Espacenet
JP 2025517969 A2025-06-121960P03952Espacenet
JP 2025517970 A2025-06-122384P03952Espacenet

1 to 10 of 120

See all 120 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APROTININCHEMBL1201619Plasma kallikrein inhibitorINHIBITORChEMBL
AVORALSTATCHEMBL4297502Plasma kallikrein inhibitorINHIBITORChEMBL
BEROTRALSTATCHEMBL5189739Plasma kallikrein inhibitorINHIBITORChEMBL
BEROTRALSTAT HYDROCHLORIDECHEMBL6067995Plasma kallikrein inhibitorINHIBITORChEMBL
ECALLANTIDECHEMBL1201837Plasma kallikrein inhibitorINHIBITORChEMBL
HUMAN C1-ESTERASE INHIBITORCHEMBL4297549Plasma kallikrein inhibitorINHIBITORChEMBL
LANADELUMABCHEMBL3545189Plasma kallikrein inhibitorINHIBITORChEMBL

Trials32

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07317050APROTININPHASE3ClinicalTrials.gov
NCT07228559AVORALSTATPHASE1ClinicalTrials.gov
NCT05460325LANADELUMABPHASE32024-12-13ClinicalTrials.gov
NCT05397431LANADELUMABClinicalTrials.gov
NCT04933721BEROTRALSTATPHASE3ClinicalTrials.gov
NCT04848272LANADELUMABPHASE1ClinicalTrials.gov
NCT04590586LANADELUMABPHASE32022-06-29ClinicalTrials.gov
NCT04527133APROTININClinicalTrials.gov
NCT04460105LANADELUMABPHASE1ClinicalTrials.gov
NCT04422509LANADELUMABPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 32

See all 32 trials

NIH grants1,110

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKLKB1 papersNewest fiscal year
P30DK036836Diabetes Research Center122025
P30CA046934University of Colorado Cancer Center Support Grant62025
R01HL144113Contact Pathway Activation on Vascular Devices62025
P30CA008748Cancer Center Support Grant42025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal42025
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI42025
ZIABC010348Protein Structure42025
ZIAHL006001Framingham Project/Levy42025
P20GM103424Louisiana Biomedical Research Network32025
P41GM108538National Center for Quantitative Biology of Complex Systems32025

1 to 10 of 1,110Source NIH's project files

See all 1,110 nih grants

Papers2,245

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Phosphorus recovery from phosphogypsum by Bacillus altitudinis.Bioresour Technol202642785692PubTator, text miningPubMed
Trypsin is as procoagulant as factor XIIa.Bleeding Thromb Vasc Biol202642712886PubTator, text miningPubMed
Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study.Diabetes Obes Metab202642638160PubTator, text miningPubMed
Lonvoguran ziclumeran: a CRISPR-CAS9-based gene therapy for the treatment of hereditary angioedema.Expert Opin Investig Drugs202642504735PubTator, text miningPubMed
Genetic architecture and cross-platform validation of apolipoprotein A-IV concentrations.Genome Biol202642449406PubTator, text miningPubMed
Deep Proteomic Analysis With Machine Learning Identifies Aqueous Humor Biomarkers of ADAMTSL4-associated Congenital Ectopia Lentis.Invest Ophthalmol Vis Sci202642423409PubTator, text miningPubMed
Mapping tissue-specific protease dynamics in the pig respiratory tract during influenza a virus infection.Sci Rep202642414375PubTator, text miningPubMed
Microbial Life-History Strategies and Functional Gene Regulation Drive Soil Nitrogen and Phosphorus Bioavailability During Succession in an Arid Valley Ecosystem.Mol Ecol202642175735PubTator, text miningPubMed
Kallikrein-8 contributes to kallikrein-kinin system dysregulation in Alzheimer's disease.Exp Neurol202642140379PubTator, text miningPubMed
Lanadelumab safety, efficacy, and pharmacokinetics in patients aged ≥12 with hereditary angioedema in China: an open-label, multicenter study.Front Immunol202642136633PubTator, text miningPubMed

1 to 10 of 2,245

See all 2,245 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3818

GET https://conductscience.org/api/genes/v1/3818/patents?page=2