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Gene · 3822

KLRC2: killer cell lectin like receptor C2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KLRC2: killer cell lectin like receptor C2. Genes, record 3822. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3822

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Gene

Symbol
KLRC2
HGNC
Name
killer cell lectin like receptor C2
HGNC
NCBI Gene ID
3822
NCBI Gene
HGNC ID
HGNC:6375
HGNC
Ensembl
ENSG00000205809
NCBI Gene
Aliases
CD159c, NKG2-C, NKG2C
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P26717NKG2-C type II integral membrane protein2311Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450762P26717Espacenet
JP 2025540077 A2025-12-111P26717Espacenet
EP 4641201 A22025-10-2910842P26717Espacenet
EP 4626925 A12025-10-081P26717Espacenet
JP 2025517969 A2025-06-1210842P26717Espacenet
US 12030936 B22024-07-0938P26717Espacenet
US 11446398 B22022-09-2044108P26717Espacenet
JP 2022530677 A2022-06-3042P26717Espacenet
JP 2022524081 A2022-04-27147079P26717Espacenet
US 11078247 B22021-08-035985P26717Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,297

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKLRC2 papersNewest fiscal year
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies452025
P01CA111412NK cells, their receptors and cancer therapy452025
P30CA008748Cancer Center Support Grant242025
P30CA077598Cancer Center Support Grant202025
P30CA016672Cancer Center Support Grant182025
R01AI100874The natural killer cell response against mouse cytomegalovirus infection142025
T32AI007290Molecular and Cellular Immunobiology132025
P30AI060354Harvard University Center for AIDS Research102025
P30CA016058Cancer Center Support Grant102025
P30DK026743UCSF Liver Center102025

1 to 10 of 1,297Source NIH's project files

See all 1,297 nih grants

Papers2,624

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Impaired control of autoimmunity increases pediatric multiple sclerosis risk in EBNA-1-seropositives and -seronegatives.Proc Natl Acad Sci U S A202642821346PubTator, text miningPubMed
Natural Killer Cells in Kidney Transplantation: Dual Role in Allograft Injury and Immune Adaptation.Arch Immunol Ther Exp (Warsz)202642814514PubTator, text miningPubMed
The Impact of Aerobic Exercise on Circulating T-Cells and NK-Cells in Colorectal Cancer Survivors: A Secondary Analysis of a Randomized Trial.Cancer Control202642808444PubTator, text miningPubMed
NKG2A-HLA-E axis contributes to an immunosuppressive checkpoint network in hepatocellular carcinoma.J Immunother Cancer202642767769PubTator, text miningPubMed
Donor NKG2A/NKG2C Immunophenotype Influences the GMP-Compliant Manufacturing Potential of NK Cells for Adoptive Immunotherapy.Cancers (Basel)202642738255PubTator, text miningPubMed
Innate immune imprints shape HIV-1 reservoir cell persistence during long-term antiretroviral therapy.Nat Immunol202642680897PubTator, text miningPubMed
Gravidity-dependent protection against placental malaria is associated with enhanced natural killer cell-mediated antibody-dependent cellular activation: a nested cohort study.EBioMedicine202642660020PubTator, text miningPubMed
The Natural Killer Cell Landscape in the Natural History of Hantavirus Cardiopulmonary Syndrome in a Chilean Cohort.Viruses202642515563PubTator, text miningPubMed
Tumor-derived ITGB3 shapes a primed but functionally constrained NK cell state in breast cancer through HLA-E-NKG2A signaling.Mol Biol Rep202642507293PubTator, text miningPubMed
Qibai Pingfei Capsule ameliorates NK‑cell dysfunction in COPD: Insights from single‑cell sequencing in a randomized multicenter double‑blinded placebo‑controlled trial.Phytomedicine202642475870PubTator, text miningPubMed

1 to 10 of 2,624

See all 2,624 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3822

GET https://conductscience.org/api/genes/v1/3822/patents