Gene · 3836
KPNA1: karyopherin subunit alpha 1
12 sourcesgene-search-2026-11-11-0.2.0
Download JSON
Cite this record
ConductScience Library. KPNA1: karyopherin subunit alpha 1. Genes, record 3836. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3836
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P52294 | Importin subunit alpha-5 | 538 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents9
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 50587 | P52294 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6836 | P52294 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6836 | P52294 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 42564 | P52294 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 145535 | P52294 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 6000 | P52294 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 231022 | P52294 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 231022 | P52294 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 231022 | P52294 | Espacenet |
Drugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,802
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KPNA1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 15 | 2025 |
| P01AI120943 | Molecular Mechanisms of Filoviral-host Interactions | 11 | 2025 |
| P30CA056036 | Translational Research in Cancer | 10 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P50AA024333 | Alcohol and tissue injury, from mechanisms to treatments | 5 | 2025 |
| R01CA136367 | Disruption of Cellular RNA Processing by Kaposi's Sarcoma-Associated Herpesvirus | 5 | 2025 |
| T32AI007647 | Training Program in Mechanisms of Virus-Host Interactions | 5 | 2025 |
| P20GM103432 | Wyoming IDeA Networks for Biomedical Research Excellence Phase 4 | 4 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,802Source NIH's project files
See all 1,802 nih grantsPapers2,991
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Targeting Nuclear Import of Thyroid Hormone Receptor Alpha with Natural Polyphenols: Potential Mechanism for Lipolysis in Metabolic Dysfunction-Associated Steatotic Liver Disease. | Curr Issues Mol Biol | 2026 | 42793229 | PubTator, text mining | PubMed |
| Signal recognition particle 14 binds to importin α in Plasmodium falciparum. | Mol Biol Rep | 2026 | 42709283 | PubTator, text mining | PubMed |
| KPNA1/importin α5 localizes to the nucleolus and associates with box C/D snoRNP complexes. | Biochem Biophys Res Commun | 2026 | 42659866 | PubTator, text mining | PubMed |
| MicroRNA-155 modulates STAT3 signaling by targeting KPNA1 in chronic chorioamnionitis of human placenta. | J Reprod Immunol | 2026 | 42623725 | PubTator, text mining | PubMed |
| Tumor-Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression. | Adv Sci (Weinh) | 2026 | 42536806 | PubTator, text mining | PubMed |
| Structures of Nicotiana benthamiana importin-α1 complexes reveal mechanisms for plant virus NLS recognition. | Plant J | 2026 | 42519839 | PubTator, text mining | PubMed |
| LncRNA ckATP1A1-AS1 inhibits influenza A virus replication by mediating innate immune responses and suppressing viral nuclear import. | J Virol | 2026 | 42496117 | PubTator, text mining | PubMed |
| Structural Insights Into the Nuclear Import of Marek's Disease Virus Large Tegument Protein. | Adv Virol | 2026 | 42338683 | PubTator, text mining | PubMed |
| Palmitoylated importin α recruits PKCε to the plasma membrane to drive breast cancer cell motility. | bioRxiv | 2026 | 42282530 | PubTator, text mining | PubMed |
| Heterozygous Nonsense Mutation in the Nuclear Transport Factor KPNA7, a Maternal Factor Active in Embryonic Tissues, Causes Autosomal Dominant Otosclerosis. | Int J Mol Sci | 2026 | 42278511 | PubTator, text mining | PubMed |
1 to 10 of 2,991
See all 2,991 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3836
GET https://conductscience.org/api/genes/v1/3836/grants?page=2