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Gene · 3838

KPNA2: karyopherin subunit alpha 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KPNA2: karyopherin subunit alpha 2. Genes, record 3838. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3838

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Gene

Symbol
KPNA2
HGNC
Name
karyopherin subunit alpha 2
HGNC
NCBI Gene ID
3838
NCBI Gene
HGNC ID
HGNC:6395
HGNC
Ensembl
ENSG00000182481
NCBI Gene
Aliases
IPOA1, PTAC58, QIP2, RCH1, SRP1-alpha, SRP1alpha
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P52292Importin subunit alpha-152917Ensembl, GeneID, HGNC

Source UniProt

Patents83

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12605438 B22026-04-217P52292Espacenet
EP 4650780 A22025-11-195967P52292Espacenet
EP 4641202 A22025-10-295042P52292Espacenet
JP 2025517970 A2025-06-125967P52292Espacenet
JP 2025024198 A2025-02-1913140P52292Espacenet
KR 1020250017231 A2025-02-045042P52292Espacenet
JP 2024123008 A2024-09-106723P52292Espacenet
JP 2024123008 A2024-09-106724P52292Espacenet
JP 2023540082 A2023-09-217P52292Espacenet
US 11446398 B22022-09-2042571P52292Espacenet

1 to 10 of 83

See all 83 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,001

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKPNA2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant62025
P30CA008748Cancer Center Support Grant42025
P30CA021765Cancer Center Support Grant (CCSG)32025
P30CA044579University of Virginia Cancer Center Support Grant32025
P01AI120943Molecular Mechanisms of Filoviral-host Interactions22025
P01CA092584Structural Cell Biology of DNA Repair Machines22025
P20GM103436IDeA Networks of Biomedical Research Excellence in Kentucky22025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant22025
P30CA016056Roswell Park Cancer Center Support Grant22025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant22025

1 to 10 of 1,001Source NIH's project files

See all 1,001 nih grants

Papers1,821

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated analysis of bulk transcriptomics and single-cell transcriptomics revealed the association characteristics between heart failure and β-hydroxybutyrylation-related genes.PLoS One202642758764PubTator, text miningPubMed
Integrated Transcriptomic Analyses Identify Four Prognosis-Associated Genes in Hepatocellular Carcinoma.Int J Mol Sci202642737438PubTator, text miningPubMed
Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9.Adv Sci (Weinh)202642725791PubTator, text miningPubMed
High KPNA2 expression predicts poor prognosis in pathological T4 colorectal cancer by importing c-Myc into the nucleus to suppress p53-dependent p21 expression.Br J Cancer202642469441PubTator, text miningPubMed
Identification and functional validation of a four-gene signature associated with radiotherapy resistance in oral squamous cell carcinoma.Transl Oncol202642456537PubTator, text miningPubMed
KPNA2 knockdown suppresses gastric cancer progression through modulation of the β-catenin/EMT signaling axis, inducing cell cycle arrest, apoptosis, and reduced metastatic capacity.J Mol Histol202642406150PubTator, text miningPubMed
KPNA2 Drives Immunosuppression in Ovarian Cancer via CCL2/CCR2-Dependent MDSC Recruitment.Cancer Sci202642331750PubTator, text miningPubMed
Acetylation-dependent regulation of FOX-Ku interaction by GCN5-SIRT1 axis controls non-homologous end-joining DNA repair.Arch Pharm Res202642322495PubTator, text miningPubMed
NCBP1 promotes the malignant progression of Wilms' tumor through stabilization of KPNA2 mRNA.Cancer Gene Ther202642310155PubTator, text miningPubMed
MYC_V1-Related Genes Affect Gastric Cancer Proliferation by Regulating Energy Metabolism and Analysis of Therapeutic Targets.Int J Mol Sci202642278393PubTator, text miningPubMed

1 to 10 of 1,821

See all 1,821 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3838

GET https://conductscience.org/api/genes/v1/3838/patents?page=2