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KRAS: KRas proto-oncogene, GTPase

1 protein, 435 patents, 3 drugs, 72 trials, 18,621 NIH grants and 83,387 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolKRASHGNC
NameKRas proto-oncogene, GTPaseHGNC
NCBI Gene ID3845NCBI Gene
HGNC IDHGNC:6407HGNC
EnsemblENSG00000133703NCBI Gene
Aliases'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, K-Ras 2, K-Ras4B, KI-RAS, KRAS1, KRAS2, NS, NS3, OES, RALD, RALD2, RASK2, c-Ki-ras, c-Ki-ras2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01116GTPase KRas189523Ensembl, GeneID, HGNCUniProt

Patents 435

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4825362 A12026-10-2147P01116Espacenet
EP 4801540 A12026-09-091P01116Espacenet
EP 4803075 A12026-09-0947P01116Espacenet
EP 4791389 A12026-08-191P01116Espacenet
EP 4774394 A12026-07-152P01116Espacenet
WO 2026121966 A22026-06-115P01116Espacenet
EP 4754118 A12026-06-105P01116Espacenet
JP 2026094307 A2026-06-0990P01116Espacenet
JP 2026086799 A2026-05-263P01116Espacenet
JP 2026515740 A2026-05-191P01116Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ADAGRASIBCHEMBL4594350GTPase KRas inhibitorINHIBITORChEMBL
SALIRASIBCHEMBL23293RAS inhibitorINHIBITORChEMBL
SOTORASIBCHEMBL4535757GTPase KRas inhibitorINHIBITORChEMBL

Trials 72

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07543172SOTORASIBPHASE2ClinicalTrials.gov
NCT07543172ADAGRASIBPHASE2ClinicalTrials.gov
NCT07415031ADAGRASIBPHASE2ClinicalTrials.gov
NCT07382726ADAGRASIBPHASE1ClinicalTrials.gov
NCT07318389SOTORASIBEARLY_PHASE1ClinicalTrials.gov
NCT07318389ADAGRASIBEARLY_PHASE1ClinicalTrials.gov
NCT07288034ADAGRASIBPHASE2ClinicalTrials.gov
NCT07172919SOTORASIBPHASE2ClinicalTrials.gov
NCT07143513SOTORASIBClinicalTrials.gov
NCT07124884SOTORASIBPHASE2ClinicalTrials.gov

NIH grants 18621

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1,2852,025NIH's project files
P30CA016672Cancer Center Support Grant1,1672,025NIH's project files
P30CA006973Regional Oncology Research Center2402,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant1682,025NIH's project files
P30CA016058Cancer Center Support Grant1642,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant1542,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant1482,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award1392,025NIH's project files
P30CA068485Cancer Center Support Grant1342,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-20281182,025NIH's project files

Papers 83387

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827184PubTator, text miningPubMed
42825474PubTator, text miningPubMed
42824995PubTator, text miningPubMed
42824375PubTator, text miningPubMed
42823844PubTator, text miningPubMed
42823821PubTator, text miningPubMed
42823659PubTator, text miningPubMed
42823566PubTator, text miningPubMed
42823414PubTator, text miningPubMed
42821569PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license