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Gene · 3848

KRT1: keratin 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KRT1: keratin 1. Genes, record 3848. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3848

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Gene

Symbol
KRT1
HGNC
Name
keratin 1
HGNC
NCBI Gene ID
3848
NCBI Gene
HGNC ID
HGNC:6412
HGNC
Ensembl
ENSG00000167768
NCBI Gene
Aliases
AEI2, CK1, EHK, EHK1, EPPK, K1, KRT1A, NEPPK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P04264Keratin, type II cytoskeletal 16443Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082974 A2026-05-19127P04264Espacenet
JP 2026004568 A2026-01-1450650P04264Espacenet
EP 4641201 A22025-10-291012P04264Espacenet
WO 2025215055 A12025-10-1626P04264Espacenet
JP 2025517969 A2025-06-121012P04264Espacenet
US 11835530 B22023-12-0510P04264Espacenet
JP 2022546545 A2022-11-04129P04264Espacenet
JP 2022141755 A2022-09-2989P04264Espacenet
US 11446398 B22022-09-2042930P04264Espacenet
JP 2022524081 A2022-04-27145901P04264Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,430

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKRT1 papersNewest fiscal year
R01AR045192REGULATORS OF EPIDERMAL GENE EXPRESSION102025
P30AR075043University of Michigan Skin Biology and Diseases Resource-based Center92025
P30CA016672Cancer Center Support Grant92025
R01AR041836Function of Desmoglein 1/Pemphigus Foliaceus Antigen82025
UL1TR001863Yale Clinical and Translational Science Award72025
R01AR043380Desmoplakin Assembly and Function in Epidermis62025
R01AR066530Regulators of epidermal growth and differentiation62025
P20GM103442ND INBRE Health & the Environment52025
P30AR069589Penn Skin Biology and Diseases Resource-based Center52025
P30CA046934University of Colorado Cancer Center Support Grant52025

1 to 10 of 1,430Source NIH's project files

See all 1,430 nih grants

Papers2,853

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Pedunculoside alleviates cheilitis-like inflammation by suppressing the TLR3/TRIF/NF-κB signaling.Int Immunopharmacol202642805066PubTator, text miningPubMed
Downregulating CHI3L2 via the STAT3 Pathway: The Mechanism of Calcitriol in Suppressing Psoriatic Inflammation and Keratinocyte Hyperproliferation.J Cell Mol Med202642747744PubTator, text miningPubMed
Palmoplantar Keratoderma: A Mechanism-Based Disease Classification.Clin Cosmet Investig Dermatol202642725047PubTator, text miningPubMed
Enzymatically Hydrolyzed Eggshell Membrane Promotes Keratinocyte Differentiation Associated With PKC and Akt Signaling Pathways.J Food Sci202642644214PubTator, text miningPubMed
Multi-omics analysis reveals the effects of Jinfeng pills on the outcomes of IVF-ET in patients with poor ovarian response: a randomized controlled trial.J Ovarian Res202642471705PubTator, text miningPubMed
High-Level Secretory Expression of Recombinant Type XVII Human-like Collagen in Komagataella phaffii.Int J Mol Sci202642353332PubTator, text miningPubMed
Decoding protein signatures and protein interactions in oral potentially malignant disorders: a systematic review and network analysis.BMC Oral Health202642316386PubTator, text miningPubMed
High-level secretory production of a highly hydrophilic human-like type III collagen in Komagataella phaffii by a multicopy genomic integration strategy.Biotechnol Lett202642217068PubTator, text miningPubMed
Loss-of-function variants in EPHX3 cause nonsyndromic epidermal differentiation disorders.Br J Dermatol202642178907PubTator, text miningPubMed
Xiao Zhen Fang mitigates cutaneous toxicity by inhibiting PANoptosis: Insights from untargeted metabolomics and transcriptomics.Fitoterapia202642167452PubTator, text miningPubMed

1 to 10 of 2,853

See all 2,853 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3848

GET https://conductscience.org/api/genes/v1/3848/patents?page=2