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Gene · 3853

KRT6A: keratin 6A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KRT6A: keratin 6A. Genes, record 3853. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3853

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Gene

Symbol
KRT6A
HGNC
Name
keratin 6A
HGNC
NCBI Gene ID
3853
NCBI Gene
HGNC ID
HGNC:6443
HGNC
Ensembl
ENSG00000205420
NCBI Gene
Aliases
CK-6C, CK-6E, CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D, PC3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P02538Keratin, type II cytoskeletal 6A5641Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450683P02538Espacenet
EP 4641201 A22025-10-2910554P02538Espacenet
WO 2025215055 A12025-10-1648P02538Espacenet
JP 2025517969 A2025-06-1210554P02538Espacenet
US 12000003 B22024-06-0428P02538Espacenet
US 11835530 B22023-12-0530P02538Espacenet
US 11446398 B22022-09-2043021P02538Espacenet
JP 2022524081 A2022-04-27145992P02538Espacenet
US 11078247 B22021-08-036033P02538Espacenet
KR 1020210075929 A2021-06-2324P02538Espacenet

1 to 10 of 45

See all 45 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,382

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKRT6A papersNewest fiscal year
P30CA008748Cancer Center Support Grant102025
P30CA016672Cancer Center Support Grant92025
P20GM103442ND INBRE Health & the Environment82025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202872025
P30CA014236Cancer Center Support Grant (CCSG)52025
P30CA016086Cancer Center Support Grant52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P30CA034196Cancer Center Support (CORE) Grant42025
P01CA013106Targeting Transcription and Splicing in Cancer32025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes32025

1 to 10 of 1,382Source NIH's project files

See all 1,382 nih grants

Papers1,808

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
[Hepatocellular carcinoma-derived lactate-mediated histone H3K18 lactylation modifies S100A2 transcription to promote proliferation, migration, invasion and epithelial-mesenchymal transition of hepatocellular carcinoma cells].
Nan Fang Yi Ke Da Xue Xue Bao202642812052PubTator, text miningPubMed
SHC1 affects oestrogen-driven differentiation and barrier function of vaginal epithelial cells via EGFR/Ras/ERK pathway.J Obstet Gynaecol202642779257PubTator, text miningPubMed
In vitro investigation of sitagliptin on HaCaT keratinocyte migration and proteomics analysis for wound healing applications.Eur J Pharmacol202642772540PubTator, text miningPubMed
Calpeptin and protein kinase C inhibition suppress exosome-associated inflammatory signaling and epidermal dysregulation in a 3-dimensional psoriatic skin model.J Pharmacol Exp Ther202642731396PubTator, text miningPubMed
Erythrocyte fatty acid compositional patterns and cardiovascular-kidney-metabolic stage burden.J Cardiol202642665016PubTator, text miningPubMed
Spatial Transcriptomics of Micropapillary, Plasmacytoid, and Sarcomatoid Urothelial Carcinoma Reveals Distinct Molecular Landscapes.Lab Invest202642641761PubTator, text miningPubMed
Molecular Evidence for KRT6A-Associated Pachyonychia Congenita Tarda with Onset at Age 53.Clin Cosmet Investig Dermatol202642577640PubTator, text miningPubMed
Proteomic Changes of Neurodegenerative and Inflammatory Plasma Biomarkers Following Traumatic Brain Injury.Neurotrauma Rep202642539370PubTator, text miningPubMed
A multi-omics prognostic model integrating disulfidptosis-related molecular features in colorectal cancer.Cancer Cell Int202642464330PubTator, text miningPubMed
Integrated hypoxia and metabolic gene signature to predict clinical outcomes and therapeutic vulnerabilities in lung adenocarcinoma.J Thorac Dis202642444878PubTator, text miningPubMed

1 to 10 of 1,808

See all 1,808 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3853

GET https://conductscience.org/api/genes/v1/3853/patents?page=2