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Gene · 3859

KRT12: keratin 12

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KRT12: keratin 12. Genes, record 3859. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3859

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Gene

Symbol
KRT12
HGNC
Name
keratin 12
HGNC
NCBI Gene ID
3859
NCBI Gene
HGNC ID
HGNC:6414
HGNC
Ensembl
ENSG00000187242
NCBI Gene
Aliases
K12, MECD1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99456Keratin, type I cytoskeletal 124940Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4795068 A12026-08-262Q99456Espacenet
JP 2026515744 A2026-05-19368Q99456Espacenet
JP 2026004568 A2026-01-1450652Q99456Espacenet
EP 4641201 A22025-10-29980Q99456Espacenet
WO 2025215055 A12025-10-1698Q99456Espacenet
JP 2025517969 A2025-06-12980Q99456Espacenet
EP 4508075 A12025-02-192Q99456Espacenet
EP 4508076 A12025-02-192Q99456Espacenet
WO 2024214081 A12024-10-17368Q99456Espacenet
US 11446398 B22022-09-2042932Q99456Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,386

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKRT12 papersNewest fiscal year
R01EY021797Development of Stem Cell-based Therapies for Limbal Stem Cell Deficiency222025
P30EY000331Vision Research Core at UCLA192025
P01CA019014Viral Oncogenesis, Latency, and Replication102025
P30EY008098Core Grant for Vision Research92025
P30CA010815Consolidated Basic Cancer Research Program72025
P30EY001792P30 Core Grant for Vision Research72025
P30EY003790Core Grant for Vision Research72025
R01CA124332Regulation of KSHV replication by N6-methyladenosine (m6A)72025
P30CA008748Cancer Center Support Grant62025
P30CA016520Abramson Cancer Center Support Grant62025

1 to 10 of 1,386Source NIH's project files

See all 1,386 nih grants

Papers2,294

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Personalized Pediatrician-Scientist Training Program Optimizes Institutional Research Investment.medRxiv202642818438PubTator, text miningPubMed
Tear proteomic atlas of local host-response states in herpes simplex keratitis.Ocul Surf202642679892PubTator, text miningPubMed
Blue Light Pollution and Ocular Surface Toxicity: p53-Mediated Ferroptosis in Corneal Epithelium Drives Dry Eye Pathogenesis.Antioxidants (Basel)202642650278PubTator, text miningPubMed
Design, synthesis, anticancer evaluation, and molecular dynamics-based computational investigation of novel pyrimidine-benzothiazole/phenyl hybrid-based VEGFR-2-targeted derivatives with antioxidant, DNA nicking, DNA interaction, and cytotoxicity studies.
Bioorg Chem202642641238PubTator, text miningPubMed
Generation of iPSC-derived limbal epithelial stem cells via a transparent defined protocol optimized by stromal cell co-culture.Exp Eye Res202642617830PubTator, text miningPubMed
Amniotic Membrane Stromal Cells Facilitate Corneal Epithelial Tissue Engineering by Promoting Limbal Epithelial Stem Cell Expansion.Invest Ophthalmol Vis Sci202642606191PubTator, text miningPubMed
Integrative Analysis Identified an Eight-Gene Risk Signature Linked to CDK7 and Explored Its Association with HCC Progression via RelA Phosphorylation.Oncol Res202642500561PubTator, text miningPubMed
Comparative efficacy of different probiotic strains and preparations for prevention of acute otitis media in children: a systematic review and network meta-analysis.Front Nutr202642491017PubTator, text miningPubMed
Growing implementation scientists: NHLBI's K12 programs in heart, lung, blood, and sleep research.Implement Sci Commun202642387667PubTator, text miningPubMed
Putative Self-Organizing Human Corneal Organoids Recapitulate Human Corneal Architecture and Cellular Diversity.Bioengineering (Basel)202642194275PubTator, text miningPubMed

1 to 10 of 2,294

See all 2,294 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3859

GET https://conductscience.org/api/genes/v1/3859/patents?page=2