Gene · 3859
KRT12: keratin 12
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KRT12: keratin 12. Genes, record 3859. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3859
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99456 | Keratin, type I cytoskeletal 12 | 494 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4795068 A1 | 2026-08-26 | 2 | Q99456 | Espacenet |
| JP 2026515744 A | 2026-05-19 | 368 | Q99456 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50652 | Q99456 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 980 | Q99456 | Espacenet |
| WO 2025215055 A1 | 2025-10-16 | 98 | Q99456 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 980 | Q99456 | Espacenet |
| EP 4508075 A1 | 2025-02-19 | 2 | Q99456 | Espacenet |
| EP 4508076 A1 | 2025-02-19 | 2 | Q99456 | Espacenet |
| WO 2024214081 A1 | 2024-10-17 | 368 | Q99456 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 42932 | Q99456 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,386
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KRT12 papers | Newest fiscal year |
|---|---|---|---|
| R01EY021797 | Development of Stem Cell-based Therapies for Limbal Stem Cell Deficiency | 22 | 2025 |
| P30EY000331 | Vision Research Core at UCLA | 19 | 2025 |
| P01CA019014 | Viral Oncogenesis, Latency, and Replication | 10 | 2025 |
| P30EY008098 | Core Grant for Vision Research | 9 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 7 | 2025 |
| P30EY001792 | P30 Core Grant for Vision Research | 7 | 2025 |
| P30EY003790 | Core Grant for Vision Research | 7 | 2025 |
| R01CA124332 | Regulation of KSHV replication by N6-methyladenosine (m6A) | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 6 | 2025 |
1 to 10 of 1,386Source NIH's project files
See all 1,386 nih grantsPapers2,294
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Personalized Pediatrician-Scientist Training Program Optimizes Institutional Research Investment. | medRxiv | 2026 | 42818438 | PubTator, text mining | PubMed |
| Tear proteomic atlas of local host-response states in herpes simplex keratitis. | Ocul Surf | 2026 | 42679892 | PubTator, text mining | PubMed |
| Blue Light Pollution and Ocular Surface Toxicity: p53-Mediated Ferroptosis in Corneal Epithelium Drives Dry Eye Pathogenesis. | Antioxidants (Basel) | 2026 | 42650278 | PubTator, text mining | PubMed |
Design, synthesis, anticancer evaluation, and molecular dynamics-based computational investigation of novel pyrimidine-benzothiazole/phenyl hybrid-based VEGFR-2-targeted derivatives with antioxidant, DNA nicking, DNA interaction, and cytotoxicity studies. | Bioorg Chem | 2026 | 42641238 | PubTator, text mining | PubMed |
| Generation of iPSC-derived limbal epithelial stem cells via a transparent defined protocol optimized by stromal cell co-culture. | Exp Eye Res | 2026 | 42617830 | PubTator, text mining | PubMed |
| Amniotic Membrane Stromal Cells Facilitate Corneal Epithelial Tissue Engineering by Promoting Limbal Epithelial Stem Cell Expansion. | Invest Ophthalmol Vis Sci | 2026 | 42606191 | PubTator, text mining | PubMed |
| Integrative Analysis Identified an Eight-Gene Risk Signature Linked to CDK7 and Explored Its Association with HCC Progression via RelA Phosphorylation. | Oncol Res | 2026 | 42500561 | PubTator, text mining | PubMed |
| Comparative efficacy of different probiotic strains and preparations for prevention of acute otitis media in children: a systematic review and network meta-analysis. | Front Nutr | 2026 | 42491017 | PubTator, text mining | PubMed |
| Growing implementation scientists: NHLBI's K12 programs in heart, lung, blood, and sleep research. | Implement Sci Commun | 2026 | 42387667 | PubTator, text mining | PubMed |
| Putative Self-Organizing Human Corneal Organoids Recapitulate Human Corneal Architecture and Cellular Diversity. | Bioengineering (Basel) | 2026 | 42194275 | PubTator, text mining | PubMed |
1 to 10 of 2,294
See all 2,294 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3859
GET https://conductscience.org/api/genes/v1/3859/patents?page=2