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Gene · 3868

KRT16: keratin 16

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KRT16: keratin 16. Genes, record 3868. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3868

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Gene

Symbol
KRT16
HGNC
Name
keratin 16
HGNC
NCBI Gene ID
3868
NCBI Gene
HGNC ID
HGNC:6423
HGNC
Ensembl
ENSG00000186832
NCBI Gene
Aliases
CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK, PC1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P08779Keratin, type I cytoskeletal 164730Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026222504 A12026-10-2232P08779Espacenet
JP 2026004568 A2026-01-1450661P08779Espacenet
US 11446398 B22022-09-2042947P08779Espacenet
JP 2022524081 A2022-04-27145918P08779Espacenet
US 11078247 B22021-08-036018P08779Espacenet
JP 2019054813 A2019-04-11231096P08779Espacenet
US 9874572 B22018-01-23240P08779Espacenet
EP 3242136 A22017-11-08240P08779Espacenet
US 9714950 B22017-07-25240P08779Espacenet
JP 2017121241 A2017-07-13231096P08779Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,120

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKRT16 papersNewest fiscal year
T32CA009110Training in Areas Fundamental to Cancer Research132025
P30CA008748Cancer Center Support Grant122025
P30CA016672Cancer Center Support Grant82025
P30AR075043University of Michigan Skin Biology and Diseases Resource-based Center72025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success72025
P20GM103442ND INBRE Health & the Environment62025
T32AR007197Training Grant in Cell and Molecular Dermatology62025
P30AR075047Skin Biology Resource-Based Center at UCI52025
K08AR078251Mechanisms of sex discrepancy in autoimmune disease: Regulation of the female-biased VGLL3 immune pathway42025
P30AI027763UCSF-Bay Area Center for AIDS Research42025

1 to 10 of 2,120Source NIH's project files

See all 2,120 nih grants

Papers3,220

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Lipoic acid synthase modulates psoriasis-like keratinocyte dysfunction in association with oxidative stress, ferroptosis-associated remodeling, and STAT3/NF-κB activation.Naunyn Schmiedebergs Arch Pharmacol202642776206PubTator, text miningPubMed
In vitro investigation of sitagliptin on HaCaT keratinocyte migration and proteomics analysis for wound healing applications.Eur J Pharmacol202642772540PubTator, text miningPubMed
Calpeptin and protein kinase C inhibition suppress exosome-associated inflammatory signaling and epidermal dysregulation in a 3-dimensional psoriatic skin model.J Pharmacol Exp Ther202642731396PubTator, text miningPubMed
Erythrocyte fatty acid compositional patterns and cardiovascular-kidney-metabolic stage burden.J Cardiol202642665016PubTator, text miningPubMed
Integrative Multi-Omics Mendelian Randomization Identifies BLMH as a Keratinocyte-Enriched Protective Candidate Gene and Potential Therapeutic Target in Psoriasis.J Inflamm Res202642634679PubTator, text miningPubMed
Direct Effects of 308-nm Excimer Light on Keratinocyte Proliferation and Differentiation in Human Organ-Cultured Skin.Int J Mol Sci202642589355PubTator, text miningPubMed
Keratin gene expression signature predicts prognosis and immunotherapy efficacy in lung adenocarcinoma.Oncol Lett202642534167PubTator, text miningPubMed
Aberrant mucin expression and keratinization distinguishing severe from mild asthma revealed by interpretable machine learning.JCI Insight202642531039PubTator, text miningPubMed
Keratin 16 puts the brakes on type I interferon signalling.Trends Mol Med202642476866PubTator, text miningPubMed
Autosomal Recessive Palmoplantar Epidermal Differentiation Disorder Caused by Homozygous Stop-Gain Variant in KRT16 Gene.Pediatr Dermatol202642476612PubTator, text miningPubMed

1 to 10 of 3,220

See all 3,220 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3868

GET https://conductscience.org/api/genes/v1/3868/patents?page=2