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Gene · 387893

KMT5A: lysine methyltransferase 5A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KMT5A: lysine methyltransferase 5A. Genes, record 387893. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/387893

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Gene

Symbol
KMT5A
HGNC
Name
lysine methyltransferase 5A
HGNC
NCBI Gene ID
387893
NCBI Gene
HGNC ID
HGNC:29489
HGNC
Ensembl
ENSG00000183955
NCBI Gene
Aliases
PR-Set7, PR/SET07, SET07, SET8, SETD8
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NQR1N-lysine methyltransferase KMT5A39318Ensembl, GeneID, HGNC

Source UniProt

Patents5

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025529142 A2025-09-046835Q9NQR1Espacenet
US 12371689 B22025-07-296835Q9NQR1Espacenet
US 11807852 B22023-11-0761Q9NQR1Espacenet
US 11098309 B22021-08-2461Q9NQR1Espacenet
US 10351853 B22019-07-1661Q9NQR1Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants885

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKMT5A papersNewest fiscal year
P30CA008748Cancer Center Support Grant222025
P30CA016086Cancer Center Support Grant82025
ZIABC010411Initiation of DNA Replication in Mammalian Cells82025
P30CA016672Cancer Center Support Grant72025
P30CA044579University of Virginia Cancer Center Support Grant72025
ZIABC005599Tumor Suppressor Protein, p5362025
P30CA016087Cancer Center Support Grant52025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control52025
R35GM131858Interrogating Complex Methylome Network with Integrated Chemical Biology Tools52025
T32CA009109Cancer Research Training Program: From Molecular Mechanisms to Therapeutic Strategies52025

1 to 10 of 885Source NIH's project files

See all 885 nih grants

Papers1,291

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Reliability of Specific High-Intensity Interval Exercise Protocol for Judo Athletes.Int J Sports Physiol Perform202642772724PubTator, text miningPubMed
KMT5A maintains muscle stem cell quiescence through epigenetic regulation of Notch signaling.iScience202642733840PubTator, text miningPubMed
SETD8-mediated mono-methylation of YAP at K76 promotes K48-linked polyubiquitination and degradation to suppress colorectal cancer.Cell Death Differ202642527521PubTator, text miningPubMed
KMT5A-mediated methylation of IRF3 promotes tumor progression through immune suppression.iScience202642495531PubTator, text miningPubMed
Unraveling the Exosome-Derived ceRNA Network of Cartilage Injury in Kashin-Beck Disease Chondrocytes.Biol Trace Elem Res202642406332PubTator, text miningPubMed
Transcriptional Dysregulation of Histone Methyltransferase Genes and Chromosomal Instability Associated With Chronic Pesticide Exposure.Environ Mol Mutagen202642318987PubTator, text miningPubMed
Genomic characterization of uterine adenomatoid tumors reveals recurrent alterations in KMT5A and KMT2C.Clin Epigenetics202642144646PubTator, text miningPubMed
Inhibition of human histone lysine methyltransferases by a redox-labile S-adenosyl-L-homocysteine analog.Sci Rep202642129275PubTator, text miningPubMed
The reprogramming and function of H4K20me1 during early embryo development.EMBO Rep202642020515PubTator, text miningPubMed
SETD8 promotes ovarian clear cell carcinoma by epigenetically activating RNA metabolism genes via H4K20me1.Sci Rep202641986648PubTator, text miningPubMed

1 to 10 of 1,291

See all 1,291 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/387893

GET https://conductscience.org/api/genes/v1/387893/grants?page=2