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Gene · 388

RHOB: ras homolog family member B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RHOB: ras homolog family member B. Genes, record 388. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/388

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Gene

Symbol
RHOB
HGNC
Name
ras homolog family member B
HGNC
NCBI Gene ID
388
NCBI Gene
HGNC ID
HGNC:668
HGNC
Ensembl
ENSG00000143878
NCBI Gene
Aliases
ARH6, ARHB, MST081, MSTP081, RHOH6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P62745Rho-related GTP-binding protein RhoB1963Ensembl, GeneID, HGNC

Source UniProt

Patents70

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192807P62745Espacenet
EP 4641201 A22025-10-292372P62745Espacenet
EP 4641202 A22025-10-294639P62745Espacenet
JP 2025517969 A2025-06-122372P62745Espacenet
JP 2025517970 A2025-06-122807P62745Espacenet
JP 2025032204 A2025-03-1134844P62745Espacenet
KR 1020250017231 A2025-02-044639P62745Espacenet
EP 4461818 A22024-11-1334844P62745Espacenet
JP 2024123008 A2024-09-108109P62745Espacenet
JP 2023058610 A2023-04-2534844P62745Espacenet

1 to 10 of 70

See all 70 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,791

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRHOB papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
P30CA008748Cancer Center Support Grant72025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant62025
P30CA068485Cancer Center Support Grant52025
T32ES018827Research Training in Environmental Toxicology52025
P30CA016086Cancer Center Support Grant42025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center42025
P30CA076292Moffitt Cancer Center Support Grant42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
P30CA016042Cancer Center Support Grant32025

1 to 10 of 1,791Source NIH's project files

See all 1,791 nih grants

Papers2,874

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Daam-, FMNL-, and mDia-family formins jointly regulate cortical actin dynamics in melanoma cells.Cell Commun Signal202642827260PubTator, text miningPubMed
PKC Inhibition by Gö6976 Promotes Osteogenic Differentiation of Dental Follicle Cells Involving Rho-Dependent Pathway Dynamics.Biomedicines202642652152PubTator, text miningPubMed
Members of the RhoA subfamily of GTPases suppress the stimulatory effect of the HPV E6 oncoprotein on the ubiquitin ligase E6AP.Sci Rep202642642544PubTator, text miningPubMed
Single-cell landscape of neutrophil activation in primary sclerosing cholangitis.Int Immunol202642578956PubTator, text miningPubMed
Bisphenol A drives the comorbidity of non-alcoholic fatty liver disease and osteoarthritis by targeting RHOB: Integrated multi-omics, single-cell analysis, and experimental validation.Exp Gerontol202642476233PubTator, text miningPubMed
Comprehensive evaluation of angiogenesis-associated genes in papillary thyroid cancer using bulk RNA and single-cell sequencing data.Eur Arch Otorhinolaryngol202642472943PubTator, text miningPubMed
tRF-17-9L5FZU3 is a novel prognostic biomarker and therapeutic target for esophageal squamous cell carcinoma: mechanisms involving RhoB suppression.Arch Biochem Biophys202642425475PubTator, text miningPubMed
SETDB1-mediated repression of RhoB promotes EMT and metastatic progression in prostate cancer.Oncogene202642420589PubTator, text miningPubMed
Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity.J Cell Biol202642360433PubTator, text miningPubMed
Integrated Bulk and Single-Cell Transcriptomic Analysis Followed by Clinical Validation Reveal Programmed Cell Death-Related Shared Molecular Signatures in OA and MDD.Int J Mol Sci202642352882PubTator, text miningPubMed

1 to 10 of 2,874

See all 2,874 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/388

GET https://conductscience.org/api/genes/v1/388/patents?page=2