ConductScience.org, home

Gene · 388585

HES5: hes family bHLH transcription factor 5

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. HES5: hes family bHLH transcription factor 5. Genes, record 388585. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/388585

On this page

Gene

Symbol
HES5
HGNC
Name
hes family bHLH transcription factor 5
HGNC
NCBI Gene ID
388585
NCBI Gene
HGNC ID
HGNC:19764
HGNC
Ensembl
ENSG00000197921
NCBI Gene
Aliases
bHLHb38
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q5TA89Transcription factor HES-51660Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448649Q5TA89Espacenet
JP 2025147176 A2025-10-0615074Q5TA89Espacenet
JP 2025028160 A2025-02-2815074Q5TA89Espacenet
KR 1020250010750 A2025-01-2115074Q5TA89Espacenet
JP 2024109657 A2024-08-1414913Q5TA89Espacenet
US 12024722 B22024-07-02221Q5TA89Espacenet
US 11998540 B22024-06-045Q5TA89Espacenet
US 11860162 B22024-01-021205Q5TA89Espacenet
JP 2022180476 A2022-12-0626Q5TA89Espacenet
US 11446398 B22022-09-2037929Q5TA89Espacenet

1 to 10 of 38

See all 38 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,283

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHES5 papersNewest fiscal year
P30CA016672Cancer Center Support Grant112025
P30CA008748Cancer Center Support Grant82025
P20GM103408Idaho INBRE Program62025
ZIABC010309Nuclear Architecture and Disease42025
P30CA006973Regional Oncology Research Center32025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)32025
P30CA014520UW Comprehensive Cancer Center Support32025
P30CA016087Cancer Center Support Grant32025
P30CA034196Cancer Center Support (CORE) Grant32025
P30CA046934University of Colorado Cancer Center Support Grant32025

1 to 10 of 1,283Source NIH's project files

See all 1,283 nih grants

Papers1,519

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
OscillomeR infers ultradian oscillations and targets of the Hes family.Patterns (N Y)202642746303PubTator, text miningPubMed
Sbno1 and Usp8 Cooperate to Enhance Notch Signaling in Regulating Neural Stem Cells.Dev Growth Differ202642323189PubTator, text miningPubMed
The people behind the papers - Veronica Biga and Cerys Manning.Development202642267616PubTator, text miningPubMed
EZH2 Upregulates Notch Signaling Pathway Genes and Increases Cell Migration in Gastric Cancers.Indian J Clin Biochem202642205216PubTator, text miningPubMed
Advances in Novel Therapeutic Strategies for Pulmonary Arterial Hypertension.Can Respir J202641949976PubTator, text miningPubMed
The role of Notch signalling and its crosstalk with oestrogen receptor signalling in breast cancer.Cancer Metastasis Rev202641894035PubTator, text miningPubMed
CRISPR and Beyond: Genome-Editing Strategies in Retinal Stem Cell Research.Cells202641892280PubTator, text miningPubMed
RNA N6-methyladenosine (m6A) regulates cell cycle progression in diffuse midline glioma (DMG) and confers sensitivity to FTO inhibition.Cell Death Dis202641888518PubTator, text miningPubMed
Plagl1 regulates the retinal progenitor cell to Müller glial cell transition.PLoS Genet202641849358PubTator, text miningPubMed
Molecular Mechanisms and Clinical Applications of Buyang Huanwu Decoction in the Treatment of Ischemic Stroke: A Review.Int J Gen Med202641810314PubTator, text miningPubMed

1 to 10 of 1,519

See all 1,519 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/388585

GET https://conductscience.org/api/genes/v1/388585/patents?page=2