Gene · 389421
LIN28B: lin-28 RNA binding posttranscriptional regulator B
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LIN28B: lin-28 RNA binding posttranscriptional regulator B. Genes, record 389421. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/389421
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q6ZN17 | Protein lin-28 homolog B | 250 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents47
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026171881 A1 | 2026-08-20 | 13 | Q6ZN17 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 51796 | Q6ZN17 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30824 | Q6ZN17 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 30824 | Q6ZN17 | Espacenet |
| JP 2023528309 A | 2023-07-04 | 31 | Q6ZN17 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 30824 | Q6ZN17 | Espacenet |
| KR 1020230016207 A | 2023-02-01 | 31 | Q6ZN17 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 46883 | Q6ZN17 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 149854 | Q6ZN17 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 6224 | Q6ZN17 | Espacenet |
1 to 10 of 47
See all 47 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,664
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LIN28B papers | Newest fiscal year |
|---|---|---|---|
| P30DK050306 | Center for Molecular Studies in Digestive and Liver Diseases | 9 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 7 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 6 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 6 | 2025 |
| R01HD082314 | Deciphering the functional role of MKRN3 in puberty and reproduction | 6 | 2025 |
| ZIAAI001185 | Roles of RNA-binding Proteins in Programming Gene Expression in Mammals | 6 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30CA093373 | Cancer Center Support Grant P30 | 5 | 2025 |
1 to 10 of 1,664Source NIH's project files
See all 1,664 nih grantsPapers2,505
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| CAFs shape the immunosuppressive microenvironment of pancreatic cancer through the Lin28b-STING Axis. | Nat Commun | 2026 | 42693143 | PubTator, text mining | PubMed |
| Precocious puberty in boys: current insights into etiology, genetic advances, and environmental factors. | Front Endocrinol (Lausanne) | 2026 | 42534783 | PubTator, text mining | PubMed |
| SARS-CoV-2 and Cancer Biology: Exploring the Mechanistic Links. | Cancer Rep (Hoboken) | 2026 | 42499246 | PubTator, text mining | PubMed |
| LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia. | Blood | 2026 | 42213620 | PubTator, text mining | PubMed |
| H2A.Z facilitates Sox2-nucleosome interaction by promoting DNA and histone H3 tail mobility. | Nucleic Acids Res | 2026 | 42033231 | PubTator, text mining | PubMed |
Co-treatment of Colchicine and Rosiglitazone synergistically inhibits cytokine-driven inflammation and modulates the related hsa-miRNA26a-5p, hsa-miRNA21-5p, and STAT3 expression in non-small cell lung cancer. | Naunyn Schmiedebergs Arch Pharmacol | 2026 | 42012657 | PubTator, text mining | PubMed |
| Heterokairic Genes and the Eco-Evo-Devo of Timing. | Evol Dev | 2026 | 41937430 | PubTator, text mining | PubMed |
| Multi-Scale Transcriptomic Sequencing Data Analysis Reveals LINC00467 is Associated with Malignant Progression in Breast Cancer: An In Silico and In Vitro Study. | Oncol Res | 2026 | 41930179 | PubTator, text mining | PubMed |
| Comparative effectiveness of 7 major human let-7-5p isoforms to modulate target gene expression in liver cells. | Drug Metab Dispos | 2026 | 41905330 | PubTator, text mining | PubMed |
| Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor. | Cell Rep | 2026 | 41850280 | PubTator, text mining | PubMed |
1 to 10 of 2,505
See all 2,505 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/389421
GET https://conductscience.org/api/genes/v1/389421/patents?page=2