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LAG3: lymphocyte activating 3

1 protein, 476 patents, 6 drugs, 163 trials, 5,397 NIH grants and 16,473 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolLAG3HGNC
Namelymphocyte activating 3HGNC
NCBI Gene ID3902NCBI Gene
HGNC IDHGNC:6476HGNC
EnsemblENSG00000089692NCBI Gene
AliasesCD223NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P18627Lymphocyte activation gene 3 protein5256Ensembl, GeneID, HGNCUniProt

Patents 476

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4831196 A22026-10-2816P18627Espacenet
EP 4806462 A22026-09-1637P18627Espacenet
EP 4796121 A22026-08-2634P18627Espacenet
WO 2026151698 A12026-07-16465P18627Espacenet
US 12624087 B22026-05-1216P18627Espacenet
US 12612446 B22026-04-28457P18627Espacenet
US 12600779 B22026-04-145P18627Espacenet
JP 2026062993 A2026-04-1044P18627Espacenet
US 12565528 B22026-03-0322P18627Espacenet
JP 2026506893 A2026-02-27127P18627Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EFTILAGIMOD ALFACHEMBL4594557Lymphocyte activation gene 3 protein vaccine antigenVACCINE ANTIGENChEMBL
FAVEZELIMABCHEMBL4297784Lymphocyte activation gene 3 protein inhibitorINHIBITORChEMBL
FIANLIMABCHEMBL4298085Lymphocyte activation gene 3 protein inhibitorINHIBITORChEMBL
IERAMILIMABCHEMBL4298009Lymphocyte activation gene 3 protein inhibitorINHIBITORChEMBL
RELATLIMABCHEMBL3990044Lymphocyte activation gene 3 protein inhibitorINHIBITORChEMBL
TEBOTELIMABCHEMBL4594578Lymphocyte activation gene 3 protein inhibitorINHIBITORChEMBL

Trials 163

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07567469FIANLIMABPHASE1/PHASE2ClinicalTrials.gov
NCT07527325FIANLIMABPHASE2ClinicalTrials.gov
NCT07511036FIANLIMABPHASE2ClinicalTrials.gov
NCT07504796RELATLIMABPHASE2ClinicalTrials.gov
NCT07459543RELATLIMABPHASE4ClinicalTrials.gov
NCT07414992FIANLIMABPHASE2ClinicalTrials.gov
NCT07369791RELATLIMABPHASE2ClinicalTrials.gov
NCT07365839FIANLIMABPHASE1ClinicalTrials.gov
NCT07346196FIANLIMABPHASE2ClinicalTrials.gov
NCT07281924RELATLIMABPHASE1/PHASE2ClinicalTrials.gov

NIH grants 5397

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1982,025NIH's project files
P30CA016672Cancer Center Support Grant1252,025NIH's project files
P30CA006973Regional Oncology Research Center712,025NIH's project files
P30CA047904Cancer Center Support Grant512,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award472,025NIH's project files
P01AI108545Synergies among inhibitory receptors in tolerance and disease432,025NIH's project files
U19AI082630Durable Alteration of the Human Immune system after Infection or Immunotherapy352,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant302,025NIH's project files
P30CA016359Cancer Center Support Grant292,025NIH's project files
P30CA016520Abramson Cancer Center Support Grant292,025NIH's project files

Papers 16473

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824783PubTator, text miningPubMed
42823731PubTator, text miningPubMed
42816994PubTator, text miningPubMed
42810570PubTator, text miningPubMed
42806691PubTator, text miningPubMed
42806527PubTator, text miningPubMed
42800812PubTator, text miningPubMed
42800259PubTator, text miningPubMed
42798509PubTator, text miningPubMed
42788733PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license