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Gene · 3909

LAMA3: laminin subunit alpha 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LAMA3: laminin subunit alpha 3. Genes, record 3909. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3909

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Gene

Symbol
LAMA3
HGNC
Name
laminin subunit alpha 3
HGNC
NCBI Gene ID
3909
NCBI Gene
HGNC ID
HGNC:6483
HGNC
Ensembl
ENSG00000053747
NCBI Gene
Aliases
BM600, BM600-150kDa, E170, JEB2A, JEB2B, JEB2C, LAMNA, LOCS, epiligrin, kalinin-165kDa, nicein-150kDa
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16787Laminin subunit alpha-33,3330Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-195557Q16787Espacenet
EP 4641201 A22025-10-295179Q16787Espacenet
JP 2025147176 A2025-10-067648Q16787Espacenet
JP 2025517969 A2025-06-125179Q16787Espacenet
JP 2025517970 A2025-06-125557Q16787Espacenet
JP 2025032204 A2025-03-1130667Q16787Espacenet
JP 2025028160 A2025-02-287648Q16787Espacenet
KR 1020250010750 A2025-01-217648Q16787Espacenet
EP 4461818 A22024-11-1330667Q16787Espacenet
JP 2024109657 A2024-08-147655Q16787Espacenet

1 to 10 of 31

See all 31 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
OCRIPLASMINCHEMBL2095222Laminin hydrolytic enzymeHYDROLYTIC ENZYME

Source ChEMBL

Trials10

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02747030OCRIPLASMINPHASE1ClinicalTrials.gov
NCT02681809OCRIPLASMINPHASE22020-12-16ClinicalTrials.gov
NCT01429441OCRIPLASMINPHASE32016-01-11ClinicalTrials.gov
NCT00996684OCRIPLASMINPHASE2ClinicalTrials.gov
NCT00798317OCRIPLASMINPHASE32013-01-30ClinicalTrials.gov
NCT00781859OCRIPLASMINPHASE32013-01-28ClinicalTrials.gov
NCT00428129OCRIPLASMINPHASE2ClinicalTrials.gov
NCT00412451OCRIPLASMINPHASE22013-09-13ClinicalTrials.gov
NCT00123305OCRIPLASMINPHASE2ClinicalTrials.gov
NCT00123266OCRIPLASMINPHASE2ClinicalTrials.gov

NIH grants936

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLAMA3 papersNewest fiscal year
P30CA006927Comprehensive Cancer Center Program at Fox Chase42025
P30EY025585NEI Center Core Grant for Vision Research42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA008748Cancer Center Support Grant32025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant32025
T32CA009560Carcinogenesis Training Program32025
F30DE029105Biofunctional sealant with peptides to extend lifespans of Class V restorations22025
P20GM130423The Kansas Institute for Precision Medicine22025
P30CA013330Cancer Center Support Grant22025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)22025

1 to 10 of 936Source NIH's project files

See all 936 nih grants

Papers1,589

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Trio-Based Whole-Exome Sequencing Identifies Convergent Epithelial Junction-Related Pathways in Syndromic Hidradenitis Suppurativa.Dermatology202642709635PubTator, text miningPubMed
Syndecan-2 enhances invasive motility in colon cancer cells via a laminin-332-integrin α6β1 axis.J Biol Chem202642607888PubTator, text miningPubMed
Single-Cell Transcriptome Analysis Reveals IRF1-Driven Epithelial States and Glycosaminoglycan-Glycolysis Coupling in Cisplatin-Resistant HGSOC.Cancer Inform202642605287PubTator, text miningPubMed
Stromal Laminin Subunit Alpha 3 is a Novel Prognostic Marker for Breast Cancer.Clin Med Insights Oncol202642558819PubTator, text miningPubMed
Rare Coexistence of Familial Laryngo-Onycho-Cutaneous Syndrome (LOCS/Shabbir Syndrome) and Epidermolysis Bullosa With Multisystemic Involvement: A Case Series.Clin Case Rep202642548784PubTator, text miningPubMed
Molecular plasticity of LAMA3 across the disease spectrum: pathogenic mechanisms and clinical translation.Histochem Cell Biol202642507193PubTator, text miningPubMed
5-Fluorouracil loaded copper‑aluminum layered double hydroxides inhibit colorectal cancer cells by inducing oxidative stress, mitochondrial membrane depolarization, apoptosis, and cell cycle arrest.Bioorg Chem202642456411PubTator, text miningPubMed
Layer-by-layer assembly of bioactive nanofilms for in situ gene transfection of a LAMA3 mutant on hydrogenated TiO₂ nanotubes: in vitro evaluation of epithelial adhesion and hemidesmosome formation.BMC Oral Health202642449345PubTator, text miningPubMed
Proteomic Analysis of Extracellular Vesicles Reveals Vitronectin and Laminin Subunit Alpha-3 as Candidate Biomarkers for Gastric Cancer.Gut Liver202642366969PubTator, text miningPubMed
Engineered Caf1 constructs encoding laminin-332 motifs: a novel approach for enhanced cutaneous wound healing.Br J Dermatol202642263674PubTator, text miningPubMed

1 to 10 of 1,589

See all 1,589 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3909

GET https://conductscience.org/api/genes/v1/3909/patents?page=2