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Gene · 3912

LAMB1: laminin subunit beta 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LAMB1: laminin subunit beta 1. Genes, record 3912. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3912

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Gene

Symbol
LAMB1
HGNC
Name
laminin subunit beta 1
HGNC
NCBI Gene ID
3912
NCBI Gene
HGNC ID
HGNC:6486
HGNC
Ensembl
ENSG00000091136
NCBI Gene
Aliases
CLM, LIS5, LKBMH, LUCAO
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07942Laminin subunit beta-11,7863Ensembl, GeneID, HGNC

Source UniProt

Patents71

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1451111P07942Espacenet
WO 2025259943 A12025-12-1813P07942Espacenet
EP 4650780 A22025-11-19557P07942Espacenet
EP 4641201 A22025-10-29394P07942Espacenet
JP 2025147176 A2025-10-067677P07942Espacenet
JP 2025529142 A2025-09-046854P07942Espacenet
US 12371689 B22025-07-296854P07942Espacenet
JP 2025517969 A2025-06-12394P07942Espacenet
JP 2025517970 A2025-06-12557P07942Espacenet
JP 2025032204 A2025-03-1130693P07942Espacenet

1 to 10 of 71

See all 71 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
OCRIPLASMINCHEMBL2095222Laminin hydrolytic enzymeHYDROLYTIC ENZYME

Source ChEMBL

Trials10

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02747030OCRIPLASMINPHASE1ClinicalTrials.gov
NCT02681809OCRIPLASMINPHASE22020-12-16ClinicalTrials.gov
NCT01429441OCRIPLASMINPHASE32016-01-11ClinicalTrials.gov
NCT00996684OCRIPLASMINPHASE2ClinicalTrials.gov
NCT00798317OCRIPLASMINPHASE32013-01-30ClinicalTrials.gov
NCT00781859OCRIPLASMINPHASE32013-01-28ClinicalTrials.gov
NCT00428129OCRIPLASMINPHASE2ClinicalTrials.gov
NCT00412451OCRIPLASMINPHASE22013-09-13ClinicalTrials.gov
NCT00123305OCRIPLASMINPHASE2ClinicalTrials.gov
NCT00123266OCRIPLASMINPHASE2ClinicalTrials.gov

NIH grants1,309

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLAMB1 papersNewest fiscal year
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital62025
P30CA016087Cancer Center Support Grant52025
U01DK062413Determining genomic and host-environment contributions to IBD phenotypes52025
U01DK062422Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations52025
U01DK062431IBD Gene Mapping by Clinical and Population Subset52025
P20GM103418Kansas IDeA Network of Biomedical Research Excellence 542025
P30CA068485Cancer Center Support Grant42025
U01DK062423Genomic and Immunologic Characterization of Inflammatory Bowel Disease and its Phenotypes42025
U01DK062432Montreal-Boston Collaborative GRC42025
P30CA016672Cancer Center Support Grant32025

1 to 10 of 1,309Source NIH's project files

See all 1,309 nih grants

Papers1,743

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Exosome-Mediated Bidirectional Signaling Regulates Glioma Stem-Cell Homeostasis and Radiation-Induced Plasticity.bioRxiv202642818566PubTator, text miningPubMed
Combination of Blastocyst Complementation and Omics Allows Fast Evaluation of Human Pathogenic Mutations in Mice.Am J Respir Cell Mol Biol202642814875PubTator, text miningPubMed
SRPK Inhibition in Cholangiocarcinoma Cells Induces LAMB1-Associated Adaptive Responses and Enhances Growth Suppression by the MEK Inhibitor U0126 via the LAMB1/ERK/c-JUN Axis.Front Biosci (Landmark Ed)202642811991PubTator, text miningPubMed
Tumor Vascular Features and Colorectal Cancer-Specific Mortality.JAMA Netw Open202642804694PubTator, text miningPubMed
[Mechanistic role of spinal Lamb1 in negative emotion-facilitated neuropathic pain regulated by the ACC-SDH pathway].Zhong Nan Da Xue Xue Bao Yi Xue Ban202642763294PubTator, text miningPubMed
Investigating the Cellular Activity and Differential Gene Expression of Human Astrocytes in Interaction with Protein Composite Nanofibers.Neurochem Res202642599588PubTator, text miningPubMed
Biallelic Frameshift Variant in LAMB1 Associated with Occipital Meningoencephalocele and Pansutural Craniosynostosis: A Case Report and Review of the Literature.Pediatr Dev Pathol202642593106PubTator, text miningPubMed
Integrative multi-omics analysis identifies stellate cell-derived complement component 7 as a predictor of fibrosis and liver-related events in MASLD.JHEP Rep202642486350PubTator, text miningPubMed
[Combined analysis of epigenetic and transcriptomic data from children with Wiedemann-Steiner syndrome due to variants of KMT2A gene].Zhonghua Yi Xue Yi Chuan Xue Za Zhi202642342635PubTator, text miningPubMed
Construction of a diagnostic model for nasopharyngeal carcinoma using a consensus machine learning approach and study of immune infiltration characteristics.Discov Oncol202642303913PubTator, text miningPubMed

1 to 10 of 1,743

See all 1,743 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3912

GET https://conductscience.org/api/genes/v1/3912/patents?page=2