Gene · 3918
LAMC2: laminin subunit gamma 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LAMC2: laminin subunit gamma 2. Genes, record 3918. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3918
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13753 | Laminin subunit gamma-2 | 1,193 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents41
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026042028 A | 2026-03-10 | 59 | Q13753 | Espacenet |
| US 12560619 B2 | 2026-02-24 | 55 | Q13753 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 51123 | Q13753 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2305 | Q13753 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1870 | Q13753 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 7694 | Q13753 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6859 | Q13753 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6859 | Q13753 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1870 | Q13753 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2305 | Q13753 | Espacenet |
1 to 10 of 41
See all 41 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| OCRIPLASMIN | CHEMBL2095222 | Laminin hydrolytic enzyme | HYDROLYTIC ENZYME |
Source ChEMBL
Trials10
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02747030 | OCRIPLASMIN | PHASE1 | ClinicalTrials.gov | |
| NCT02681809 | OCRIPLASMIN | PHASE2 | 2020-12-16 | ClinicalTrials.gov |
| NCT01429441 | OCRIPLASMIN | PHASE3 | 2016-01-11 | ClinicalTrials.gov |
| NCT00996684 | OCRIPLASMIN | PHASE2 | ClinicalTrials.gov | |
| NCT00798317 | OCRIPLASMIN | PHASE3 | 2013-01-30 | ClinicalTrials.gov |
| NCT00781859 | OCRIPLASMIN | PHASE3 | 2013-01-28 | ClinicalTrials.gov |
| NCT00428129 | OCRIPLASMIN | PHASE2 | ClinicalTrials.gov | |
| NCT00412451 | OCRIPLASMIN | PHASE2 | 2013-09-13 | ClinicalTrials.gov |
| NCT00123305 | OCRIPLASMIN | PHASE2 | ClinicalTrials.gov | |
| NCT00123266 | OCRIPLASMIN | PHASE2 | ClinicalTrials.gov |
NIH grants1,208
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LAMC2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA062203 | Cancer Center Support Grant | 5 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 4 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 3 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 3 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 3 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 3 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,208Source NIH's project files
See all 1,208 nih grantsPapers2,268
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Epithelial integration in tissue-engineered oral mucosa using RGDTFI-presenting micropatterned collagen scaffolds. | J Oral Biosci | 2026 | 42628342 | PubTator, text mining | PubMed |
| LAMC2+ Epithelial Cells Drive Bladder Cancer Progression and Predict Immunotherapy Response via SERPINB3/STAT3/CD44 Axis. | Cancer Sci | 2026 | 42554210 | PubTator, text mining | PubMed |
| Golgi Protein 73 and Laminin-γ2 Monomer-Based Score for the Diagnosis of Advanced Liver Fibrosis in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease. | JGH Open | 2026 | 42548774 | PubTator, text mining | PubMed |
| CLOCK confers EGFR-TKIs resistance in non-small cell lung cancer by transcriptionally upregulating LAMC2 expression and activating multiple kinase signaling. | Arch Biochem Biophys | 2026 | 42526733 | PubTator, text mining | PubMed |
| Laminin γ2-ITGβ1-PD-L1 axis mediates gastric cancer cell heterogeneity in response to GCMSCs via FAK/YAP pathway. | Cell Signal | 2026 | 42492819 | PubTator, text mining | PubMed |
| Analysis of the relationship between serum LAMC2, TROAP and clinical stages and prognosis of non-muscle invasive bladder cancer. | Open Med (Wars) | 2026 | 42441309 | PubTator, text mining | PubMed |
| ACOT9, a mitochondrial metabolism-related gene, promotes ROS-associated epithelial remodeling in laryngeal squamous cell carcinoma. | J Transl Med | 2026 | 42343374 | PubTator, text mining | PubMed |
| Revealing the Action Mechanism of the FOXA2-LAMC2 Axis in Driving Cisplatin Resistance of Head and Neck Squamous Cell Carcinoma via Based Multi-Omic Analysis and Experimental Validation. | Chem Biol Drug Des | 2026 | 42319071 | PubTator, text mining | PubMed |
| Comprehensive Integrated Single-Cell and Spatial Transcriptomics Unveil the Dynamic Landscape of Betel Nut-Associated Oral Mucosal Carcinogenesis and Its Tumor Microenvironment. | MedComm (2020) | 2026 | 42253932 | PubTator, text mining | PubMed |
| Laminin Gamma 2 (LAMC2)-Targeting F(ab')2 for 89Zr Immuno-PET Imaging of Human NSCLC Xenograft Models. | Mol Pharm | 2026 | 42212402 | PubTator, text mining | PubMed |
1 to 10 of 2,268
See all 2,268 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3918
GET https://conductscience.org/api/genes/v1/3918/patents?page=2